Abstract
Ten unmedicated and ten medicated patients with major depression and ten controls were investigated with IBZM-SPECT. The ten unmedicated patients were reinvestigated after treatment with tricyclic antidepressants. Dopamine D2 receptor occupancy was not different between patients and controls, or medicated and unmedicated patients. IBZM binding was increased in four patients with psychomotor retardation. Antidepressant therapy led to a decrease in IBZM binding in the five improved patients. Dopamine D2 receptor binding remained unchanged in nonresponders. It is concluded that striatal dopamine D2 receptor binding is not changed in depression or by tricyclic antidepressants; however, it is affected by psychomotor activity. The changes observed might be the result of increased tonic dopamine release in the basal ganglia, but several other explanations exist.
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References
American Psychiatric Association (1987) Diagnostic and statistical manual of mental disorders, 3rd edn revised. APA, Washington
Brodie JD, Smith GS, Dewey SL, Bartlett EJ, Logan J, Simkowitz P, Fowler JS, Wolf AP (1994) Measuring pharmacological activity by PET: imaging the neurochemical and metabolic response to challenge. Neuropsychopharmacology 10:694S
Dewey SL, Smith GS, Logan J, Brodie JD, Fowler JS, Wolf AP (1993) Striatal binding of the PET ligand11C-raclopride is altered by drugs that modify synaptic dopamine levels. Synapse 13:350–356
D'haenen HA, Bossuyt A (1994) Dopamine D2 receptors in depression measured with SPECT. Biol Psychiatry 35:128–132
Ebert D, Feistel H, Barocka A, Kaschka WP, Pirner A (1994) SPECT assessment of cerebral dopamine D2 receptor blockade in depression before and after sleep deprivation. Biol Psychiatry 35:880–885
Fibiger HC (1995) Neurobiology of depression: focus on dopamine. In: Gessa G, Fratta W, Pani L, Serra G (eds) Depression and mania: from neurobiology to treatment. Raven Press, New York, pp 1–17
George MS, Ketter TA, Post RM (1993) SPECT and PET imaging in mood disorders. J Clin Psychiatry 54 [11]:6–13
Hall H, Wedel I, Halldin C, Kopp J, Farde L (1990) Comparison of the in vitro receptor binding properties of N3H-methylspiperone and3H-raclopride to rat and human brain membranes. J Neurochem 55:2048–2057
Hamilton M (1967) Development of a rating scale for primary depressive illness. Br J Soc Clin Psychol 6:278–296
Kaschka W, Feistel H, Ebert D (1995) Reduced benzodiazepine receptor binding in panic disorders measured by iomazenil SPECT. J Psychiat Res 5:427–434
Laruelle E (1995) SPECT imaging of striatal dopamine release after amphetamine. J Nucl Med 36:1182–1190
Logan J, Dewey S, Wolf A, Fowler J, Brodie J, Angrist B, Volkow N, Gatley J (1991) Effects of endogenous dopamine on measures of18FN-methylspiroperidol binding in the basal ganglia. Synapse 9:195–207
Pearlson GD, Wong DF, Tune LE, Ross A, Chase G, Links J, Dannals R, Wilson A, Ravert H, Wagner H, Depaulo R (1995) In-vivo dopamine D2 receptor density in psychotic and nonpsychotic patients with bipolar disorder. Arch Gen Psychiatry 52:471–477
Smith GS, Dewey SL, Brodie JD, Bartlett EJ, Simkowitz Ph, Riedel R, Fujita H, Cancro R, Wolf AP (1995) Bildliche Darstellung von Neurotransmitterinteraktionen in vivo mittels PET. In: Gerlach, Schizophrenie: Dopaminrezeptoren und Neuroleptika. Springer, Berlin, pp 104–124
Willner P (1995) Dopaminergic mechanisms in depression and mania. In: Bloom FE, Kupfer DJ (eds) Psychopharmacology. Raven Press, New York, pp 921–932
Woods SW, Seibyl JP, Goddard AW, Dey HM, Zoghbi SS, Germine M, Baldwin RM, Smith EO, Charney DS, Henninger GR, Hoffer PB, Innis RB (1992) Dynamic SPECT imaging after injection of the benzodiazepine ligand iomazenil in healthy human subjects. Psychiatry Res Neuroimaging 45:67–77
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Ebert, D., Loew, T., Feistel, H. et al. Dopamine and depression — Striatal dopamine D2 receptor SPECT before and after antidepressant therapy. Psychopharmacology 126, 91–94 (1996). https://doi.org/10.1007/BF02246416
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DOI: https://doi.org/10.1007/BF02246416