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Inhibition of histamine release and ionophore-induced calcium flux in rat mast cells by lidocaine and chlorpromazine

  • Histamine and Kinins
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Abstract

We studied the effects of lidocaine (L) and chlorpromazine (C), two compounds known to affect the binding of calcium to cell membranes, on histamine release and45calcium uptake by purified mast cells upon challenge with the ionophore A23,187 or with compound 48/80. At low concentrations L and C inhibited the Ca++ flux as well as histamine release while higher concentrations caused enhancement in this function. Evidence was obtained that L 10−4 M may displace Ca++ from the cell membranes.

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Authors and Affiliations

  1. Hypersensitivity Diseases Research, The Upjohn Company, 49001, Kalamazoo, MI, USA

    Herbert G. Johnson & Merdis D. Miller

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  1. Herbert G. Johnson
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  2. Merdis D. Miller
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Johnson, H.G., Miller, M.D. Inhibition of histamine release and ionophore-induced calcium flux in rat mast cells by lidocaine and chlorpromazine. Agents and Actions 9, 239–243 (1979). https://doi.org/10.1007/BF01966694

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  • DOI: https://doi.org/10.1007/BF01966694

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