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Intestinale Disaccharidasen bei juvenilem Diabetes mellitus

Intestinal disaccharidase activities in juvenile diabetes mellitus

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Summary

Intestinal disaccharidase activity is significantly elevated in experimental diabetes of rats. In man, only reports of disaccharidase activity in “maturity-onset” diabetes are available. This study deals with activities of maltase, sucrase, lactase, trehalase, and cellobiase in small bowel biopsies from juvenile diabetics. Activities were not different from those in controls. It is rather more than likely that insulin already given to the diabetics had normalized intestinal disaccharidase activities. The close relationship between intestinal hexose transport and disaccharidase activity and the regulation of both parameters by hormonal and luminal factors are discussed with respect to juvenile diabetes mellitus.

Zusammenfassung

Beim experimentellen Diabetes der Ratte sind die Aktivitäten intestinaler Disaccharidasen signifikant erhöht. Für den Menschen liegen diesbezüglich bislang nur Untersuchungen beim Erwachsenen- und Altersdiabetes vor. Wir haben bei einer Gruppe juveniler Diabetiker die Aktivitäten von Maltase, Saccharase, Lactase, Trehalase und Cellobiase in der Jejunalschleimhaut bestimmt. Es fand sich kein statistisch relevanter Unterschied der Aktivitäten gegenüber einem Kontrollkollektiv gleichaltriger stoffwechselgesunder Kontrollpersonen. Möglicherweise hatte die bereits durchgeführte Insulinbehandlung zur Normalisierung der Aktivitäten geführt. Die enge Koppelung von intestinaler Zuckerabsorption und Disaccharidasen, sowie deren Regulation durch hormonelle und luminale Faktoren werden im Zusammenhang mit dem juvenilen Diabetes mellitus diskutiert.

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  1. Medizinische Klinik mit Poliklinik der Universität Erlangen-Nürnberg, Erlangen

    H. Ruppin, W. Domschke, S. Domschke & M. Classen

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  1. H. Ruppin
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  2. W. Domschke
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  3. S. Domschke
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  4. M. Classen
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Ruppin, H., Domschke, W., Domschke, S. et al. Intestinale Disaccharidasen bei juvenilem Diabetes mellitus. Klin Wochenschr 52, 568–570 (1974). https://doi.org/10.1007/BF01468497

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