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In vivo degradation of collagen-vicryl materials in rabbit ear chambers

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Abstract

Thein vivo breakdown of collagen-vicryl composites (types 9 and 12) was followed in rabbit ear chambers over a period of 5 weeks. In this time the implants were incorporated into the granulation tissue growing in the chambers. Materials that were sterilized by gamma irradiation were resorbed faster than those sterilized with ethylene oxide or disinfected with alcohol, which suggests that irradiation weakened the material. Histological observation revealed that the collagen component had disappeared from all the composites by day 35 and the surrounding tissue showed a mild foreign-body reaction.

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Author notes

  1. I. N. Bird

    Present address: Yamanouchi Research Institute (UK), Littlemore Hospital, OX44XN, Oxford, UK

Authors and Affiliations

  1. Department of Pathology, School of Medical Sciences, BS8 1TD, Bristol, UK

    I. N. Bird & I. A. Silver

  2. Devro Ltd, Moodiesburn, Chryston, G69 0JE, Glasgow, UK

    S. D. Gorham

  3. Ethicon Ltd, Bankhead Ave, Sighthill Industrial Estate, EH11 4HE, Edinburgh, UK

    D. A. French

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  1. I. N. Bird
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  2. I. A. Silver
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  3. S. D. Gorham
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  4. D. A. French
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Bird, I.N., Silver, I.A., Gorham, S.D. et al. In vivo degradation of collagen-vicryl materials in rabbit ear chambers. J Mater Sci: Mater Med 2, 36–42 (1991). https://doi.org/10.1007/BF00701685

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