Summary
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1.
Observations on CSF pathways and behaviour of the BBB were carried out in lemon and nurse sharks, native of Bahama waters.
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2.
Intraventricularly injected Evans blue in albumin solution filled the ependymalined ventricles, olfactory and cerebellar canals, as well as the saccus vasculosus, without any evidence of reaching and spreading along the external surfaces of the brain.
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3.
Localized physical and chemical injuries to the brain failed to produce in sharks any significant extravasation of the intravenously administered tracer indicating a striking resistance of the blood-brain barrier.
Zusammenfassung
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1.
An den in der Bahama-See lebenden Citronen- und Ammenhaien wurden Untersuchungen über die Liquor-Zirkulationswege und das Verhalten der Blut-Hirn-Schranke ausgeführt.
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2.
Intraventrikulär injiziertes, mit Albumin gemischtes Evansblau erfüllte die Ependym-ausgekleideten Ventrikel, die Riechhirn- und Kleinhirnkanäle, sowie den Saccus vasculosus, ohne die äußeren Oberflächen des Gehirns zu erreichen und sich ihnen entlang auszubreiten.
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3.
Örtliche physikalische und chemische Hirnläsionen riefen bei den Haien keine deutliche Permeation der i.v. verabreichten Markierungslösung hervor, was auf eine auffallende Resistenz der Blut-Hirn-Schranke hinweist.
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Klatzo, I., Steinwall, O. Observation on cerebrospinal fluid pathways and behaviour of the blood-brain barrier in sharks. Acta Neuropathol 5, 161–175 (1965). https://doi.org/10.1007/BF00686516
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DOI: https://doi.org/10.1007/BF00686516