Abstract
The authors measured serum neuroleptic activity and serum prolactin levels in 26 schizophrenic outpatients on prolonged neuroleptic therapy. Of the 24 patients, 11 had moderafe to severe tardive dyskinesia, as assessed by the Abnormal Involuntary Movement Scale (AIMS). AIMS scores were positively correlated with age, duration of illness, and negative schizophrenic symptoms, but not with variables of neuroleptic exposure, current serum levels of neuroleptic activity, or serum prolactin levels. Neuroleptic activity and prolactin levels were positively correlated, and both variables also correlated with the current daily dose of neuroleptics.
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References
Brown WA, Laughren TP (1981) Low serum prolactin and early relapse following neuroleptic withdrawal. Am J Psychiatry 138:237–239
Calil HM, Avery DH, Hollister LE, Creese I, Snyder SH (1979) Serum levels of neuroleptics measured by dopamine radioreceptor assay and some clinical observations. Psychiatr Res 1:39–44
Creese I, Snyder SH (1977) A simple and sensitive radioreceptor assay for antischizophrenic drugs in blood. Nature 270:180–182
Crow TJ (1980) Molecular pathology of schizophrenia: More than one disease process? Br Med J 280:66–68
Csernansky JG, Grabowski K, Cervantes J, Kaplan J, Yesavage JA (1981) Fluphenazine decanoate and tardive diskinesia: A possible association. Am J Psychiatry 138:1362–1365
Gardos G, Gole JO (1980) Overview: Public health, issues in tardive dyskinesia. Am J Psychiatry 137:776–781
Gardos G, Gole JO, LaBrie RA (1977) Drug variables in the etiology of tardive dyskinesia: Application of discriminant function analysis. Prog Psychopharmacol 1:147–154
Gruen PH, Sachar EJ, Altman N, Langer G, Tabrizi MA, Halpern FS (1978) Relation of plasma prolactin to clinical response in schizophrenic patients. Arch Gen Psychiatry 35:1222–1227
Hollister LE (1977) Antipsychotic medications and the treatment of schizophrenia. In: Barchas JD, Berger PA, Ciaranello RD, Elliott GR (eds) Psychopharmacology, from theory to practice. Oxford New York, pp 121–150
Jeste DV, DeLisi LE, Zalcman S, Wise CD, Phelps BH, Rosenblatt JE, Potkin SG, Bridge TP, Wyatt RJ (1981) A biochemical study of tardive dyskinesia in young mela patients. Psychiatr Res 4:327–331
Jeste DV, Linnoila M, Wagner RL, Wyatt RJ (1982) Serum neuroleptic concentrations and tardive dyskinesia. Psychopharmacology 76:377–380
Klawans HL, Goetz GG, Perlik S (1980) Tardive dyskinesia: Review and update. Am J Psychiatry 137:900–908
Laughren TP, Brown WA, Williams BW (1979) Serum prolactin and clinical states during neuroleptic treatment and withdrawal. Am J Psychiatry 136:108–110
McGeer E, McGeer PL (1976) Age changes in the human for some enzymes associated with metabolism of catecholamines, GABA, and acetylcholine. In: Ordee JM, Brizee RR (eds) Neurobiology of aging. Raven, New York, pp 389–404
Meltzer HY, Fang vS (1976) The effect of neuroleptics on serum prolactin in schizophrenic patients. Arch Gen Psychiatry 33:279–286
Nasrallah HA (1980) Neuroleptic plasma levels and tardive dyskinesia: A possible link? Schizophr Bull 6:4–7
Owen DGC, Johnstone EC, Frith CD (1982) Spontaneous involuntary disorders of movement. Arch Gen Psychiatry 39:452–461
White P, Hiley CR, Goodhardt MJ, Carrasco LH, Keet JP, Williams LEI, Brown DM (1977) Neocortical cholinergic neurons in elderly people. Lancet I:668–669
Yesavage JA, Holman CA, Becker J, Cohn R (1981) Correlation of age and acute thiothixene levels. Psychopharmacology 74:117–120
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Csernansky, J.G., Kaplan, J., Holman, C.A. et al. Serum neuroleptic activity, prolactin, and tardive dyskinesia in schizophrenic outpatients. Psychopharmacology 81, 115–118 (1983). https://doi.org/10.1007/BF00429003
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DOI: https://doi.org/10.1007/BF00429003