Abstract
In Parkinson’s disease (PD), clinical observations and some studies suggest that depression and anxiety are linked to motor fluctuations. We studied prospectively 10 patients with advanced PD just before initiation of intrajejunal levodopa/carbidopa therapy, and after 1 and 3 months of regular treatment. Motor symptoms, motor fluctuations, non-motor symptoms, quality of sleep, symptoms of depression and anxiety were evaluated with the appropriate scales. As expected, motor symptoms and motor fluctuations improved considerably. Non-motor symptoms, quality of sleep and depression also improved significantly. However, anxiety score remained unchanged during the study. Our data in a small numbers of patients indicate that all aspects of mental and psychic symptoms are not alleviated within a short period of reduction of motor fluctuations.
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References
Stocchi F, Olanow CW (2004) Continuous dopaminergic stimulation in early and advanced Parkinson’s disease. Neurology 62:S56–S63
Bredberg E et al (1993) Intraduodenal infusion of a water-based levodopa dispersion for optimisation of the therapeutic effect in severe Parkinson’s disease. Eur J Clin Pharmacol 45:117–122
Nilsson D et al (1998) Long-term intraduodenal infusion of a water based levodopa-carbidopa dispersion in very advanced Parkinson’s disease. Acta Neurol Scand 97:175–183
Nilsson D, Nyholm D, Aquilonius SM (2001) Duodenal levodopa infusion in Parkinson’s disease––long-term experience. Acta Neurol Scand 104:343–348
Honig H et al (2009) Intrajejunal levodopa infusion in Parkinson’s disease: a pilot multicenter study of effects on nonmotor symptoms and quality of life. Mov Disord 24:1468–1474
Richard IH et al (2004) The ups and downs of Parkinson disease: a prospective study of mood and anxiety fluctuations. Cogn Behav Neurol 17:201–207
Storch A et al (2013) Nonmotor fluctuations in Parkinson disease: severity and correlation with motor complications. Neurology 80:800–809
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Study protocol ans inform consent were submitted to the Ethics committees of both hospital participating to this study. Enrollement started only after acceptation.
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Bellante, F., Dethy, S. & Zegers de Beyl, D. Depression, anxiety and non-motor symptoms on initiation of intrajejunal levodopa/carbidopa therapy. Acta Neurol Belg 116, 39–41 (2016). https://doi.org/10.1007/s13760-015-0497-x
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DOI: https://doi.org/10.1007/s13760-015-0497-x