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Changes in adrenergic receptors during the development of heart failure

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Abstract

Moderate and severe stages of congestive heart failure due to the loss of myocardium upon coronary occlusion in rats was associated with an increase in alpha-adrenergic receptors and a decrease in beta-adrenergic receptors in the viable left ventricle. However, at early stages of heart failure the number of beta-adrenergic receptors was decreased without any changes in the number of alpha-adrenergic receptors. The affinities of these receptors to alpha receptor antagonist (3H-prazosin) and beta receptor antagonist (3H-dihydroalprenolol) were not altered in the failing hearts. On the other hand, the pattern of changes in both alpha- and beta-adrenergic receptors in heart membranes treated with oxygen free radical generating system was different from that seen in the failing hearts. In particular, the affinities for these receptors were decreased whereas the number of beta-receptors was increased and the number of alpha-receptors was decreased or unchanged. These results indicate that alterations in the adrenergic receptors in heart failure are not due to the formation of oxygen free radicals.

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Authors and Affiliations

  1. Division of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, 351 Tache Avenue, R2H 2A6, Winnipeg, Manitoba, Canada

    Naranjan S. Dhalla, Ian M. C. Dixon, Shingo Suzuki, Masanori Kaneko, Akira Kobayashi & Robert E. Beamish

  2. Department of Physiology, Faculty of Medicine, University of Manitoba, R2H 2A6, Winnipeg, Manitoba, Canada

    Naranjan S. Dhalla, Ian M. C. Dixon, Shingo Suzuki, Masanori Kaneko, Akira Kobayashi & Robert E. Beamish

Authors
  1. Naranjan S. Dhalla
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  2. Ian M. C. Dixon
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  3. Shingo Suzuki
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  4. Masanori Kaneko
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  5. Akira Kobayashi
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  6. Robert E. Beamish
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Dhalla, N.S., Dixon, I.M.C., Suzuki, S. et al. Changes in adrenergic receptors during the development of heart failure. Mol Cell Biochem 114, 91–95 (1992). https://doi.org/10.1007/BF00240302

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