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Blockade of α2-Adrenergic Receptors Inhibits Functional Parameters of Langendorff-Isolated Rat Heart

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We studied the effect of α2-adrenoreceptor antagonist yohimbine in concentrations of 10—9-10—6 M on the inotropy, chronotropy, and coronary flow of the Langendorff-isolated rat heart. It was found that antagonist of α2-adrenoreceptors yohimbine changes all the studied parameters of the isolated heart. The force of left ventricular myocardial contraction, HR, and coronary flow decreased after application of all concentrations of α2-adrenoreceptor antagonist. The maximum inotropic, chronotropic, and vascular effects were observed when the antagonist was applied to the perfused solution in a concentration of 10—9 M. The minimum decrease in coronary flow and HR was observed when yohimbine was applied in a concentration of 10—8 M; minimum effect on myocardial contractility was revealed at α2-adrenoreceptor blocker concentration of 10—7 M.

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Authors and Affiliations

  1. Department of Human Health Protection, Kazan (Volga Region) Federal University, Kazan, the Republic of Tatarstan, Russia

    L. I. Khisamieva, N. N. Chershintseva, A. M. Kuptsova, N. I. Ziyatdinova & T. L. Zefirov

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  1. L. I. Khisamieva
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  2. N. N. Chershintseva
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  3. A. M. Kuptsova
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  4. N. I. Ziyatdinova
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  5. T. L. Zefirov
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Correspondence to T. L. Zefirov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 172, No. 9, pp. 273-276, September, 2021

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Khisamieva, L.I., Chershintseva, N.N., Kuptsova, A.M. et al. Blockade of α2-Adrenergic Receptors Inhibits Functional Parameters of Langendorff-Isolated Rat Heart. Bull Exp Biol Med 172, 288–291 (2022). https://doi.org/10.1007/s10517-022-05378-6

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  • DOI: https://doi.org/10.1007/s10517-022-05378-6

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