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Role of Growth Factors in the Treatment of Diabetic Foot Ulceration

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Diabetic Foot Ulcer

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Abstract

Chronic foot ulceration is a common complication of diabetes mellitus which often leads to lower extremity amputation. Foot ulcer healing is a process that involves the interaction of various cells such as fibroblast, macrophages, keratinocytes to promote complex processes such as chemotaxis, angiogenesis, mitogenesis, apoptosis, and synthesis of extracellular matrix components. Presently, several therapeutic options are available to treat foot ulceration. Among them, treating patients with different growth factors is one of the most popular options. Growth factors are the polypeptides released by the blood platelets, endothelial cells, and macrophages, which are responsible for cellular growth and differentiation. Several growth factors also have the potential of promoting wound healing in diabetic patients. The subject of this chapter is the role of important growth factors in the treatment of diabetic foot ulceration and the possible promising approaches for foot ulcer management.

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Abbreviations

ECM:

Extracellular matrix

rhEGF:

Recombinant human epidermal growth factor

rhPDGF:

Recombinant human platelet-derived growth factor

S4PL:

Syndecan-4 proteo liposomes

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Acknowledgments

D.S. expresses her sincere gratitude to CSIR, India for Fellowship. H.R.S. is thankful to the UGC [Grant no. F.30-377/2017(BSR)] and DST-SERB (Grant no. EMR/20l7/001758), New Delhi, for providing financial help.

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Authors and Affiliations

  1. Molecular Cancer Genetics and Translational Research Lab, Section of Genetics, Department of Zoology, Aligarh Muslim University, Aligarh, India

    Deepti Singh & Hifzur R. Siddique

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  1. Deepti Singh
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  2. Hifzur R. Siddique
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Correspondence to Hifzur R. Siddique .

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Editors and Affiliations

  1. Department of Medical Microbiology, Faculty of Medicine, University of Tabuk, Tabuk, Saudi Arabia

    Mohammad Zubair

  2. Consultant, Diabetes & Endocrinology, Superspeciality Center, Aligarh, Uttar Pradesh, India

    Jamal Ahmad

  3. Ex-Chairperson-Department of Microbiology, Former Dean-Faculty of Medicine, J N Medical College & Hospital Faculty of Medicine, Aligarh Muslim University, Aligarh, Uttar Pradesh, India

    Abida Malik

  4. Research Associate, Bioanalytical Department, AXIS Clinicals, Hyderabad, Telangana, India

    Mallikarjuna Rao Talluri

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Singh, D., Siddique, H.R. (2021). Role of Growth Factors in the Treatment of Diabetic Foot Ulceration. In: Zubair, M., Ahmad, J., Malik, A., Talluri, M.R. (eds) Diabetic Foot Ulcer. Springer, Singapore. https://doi.org/10.1007/978-981-15-7639-3_15

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  • DOI: https://doi.org/10.1007/978-981-15-7639-3_15

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