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MicroRNA-Targeted Therapeutics for Ischemic Stroke: Status, Gaps and the Way Forward

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IschemiRs: MicroRNAs in Ischemic Stroke

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Abstract

Post-stroke miRNA modulation is anticipated to revolutionize ischemic stroke therapeutic landscape despite the challenges and the future efforts necessary for the successful translation of preclinical observations to clinical practice. This chapter summarizes the currently employed strategies for the restoration or inhibition of microRNA (miRNA) function and the methods used for the delivery of miRNAs. The rising interest in the use of pharmacological agents and small-molecules to regulate miRNA expression, with special emphasis on ischemic stroke, has also been discussed.

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Authors and Affiliations

  1. School of Biotechnology, National Institute of Technology Calicut, Calicut, India

    Rajanikant G. K. & Gokul Surendran

  2. NeuroDiderot, Inserm, Université de Paris, Paris, France

    Pierre Gressens & Cindy Bokobza

  3. Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition INSERM 1172, Lille, France

    Sreekala S. Nampoothiri

Authors
  1. Rajanikant G. K.
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  2. Pierre Gressens
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  3. Sreekala S. Nampoothiri
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  4. Gokul Surendran
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  5. Cindy Bokobza
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Correspondence to Rajanikant G. K. .

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G. K., R., Gressens, P., Nampoothiri, S.S., Surendran, G., Bokobza, C. (2020). MicroRNA-Targeted Therapeutics for Ischemic Stroke: Status, Gaps and the Way Forward. In: IschemiRs: MicroRNAs in Ischemic Stroke. Springer, Singapore. https://doi.org/10.1007/978-981-15-4798-0_11

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