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Histone Deacetylases and Oxidative Stress: Role in Diabetic Cardiomyopathy

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Oxidative Stress in Heart Diseases

Abstract

Diabetic cardiomyopathy is a serious complication of diabetes and is associated with severe morbidity and mortality. Several new targets have been identified for diabetic cardiomyopathy. Oxidative stress plays an important role in diabetic cardiomyopathy and several anti-oxidants are reported to exhibit cardioprotective effects in diabetes. Histone deacetylases (HDAC) are group of enzymes involved in epigenetic regulation of genes and thereby exhibit varied effects. In addition to diabetic cardiomyopathy, HDACs are known to play a role in various diseases like cancer, neurological disorders, immune diseases etc. Documented evidences have suggests role of histone modifications in diabetic cardiomyopathy and hence HDACs serve as an important therapeutic target for diabetic cardiomyopathy. The present book chapter provides an overview of histone modifications in diabetic cardiomyopathy and exploring HDACs as therapeutic option for the same.

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Authors and Affiliations

  1. Department of Pharmacology, Institute of Pharmacy, Nirma University, Ahmedabad, India

    Bhoomika M. Patel

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Editors and Affiliations

  1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. Institute of Cardiovascular Sciences, St Boniface Hospital, Albrechtsen Research Centre, Winnipeg, MB, Canada

    Naranjan S Dhalla

  3. Translational Health Science and Technology (THSTI), Department of Biotechnology, Faridabad, India

    Nirmal K Ganguly

  4. Translational Health Science and Technology (THSTI), Department of Biotechnology, Faridabad, India

    Madhu Dikshit

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Patel, B.M. (2019). Histone Deacetylases and Oxidative Stress: Role in Diabetic Cardiomyopathy. In: Chakraborti, S., Dhalla, N., Ganguly, N., Dikshit, M. (eds) Oxidative Stress in Heart Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-13-8273-4_18

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