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Human T-Cell Leukemia Virus Type 1 Infection and Adult T-Cell Leukemia

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Infectious Agents Associated Cancers: Epidemiology and Molecular Biology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1018))

Abstract

Human T-cell leukemia virus type 1 (HTLV-1) is the first retrovirus discovered to cause adult T-cell leukemia (ATL), a highly aggressive blood cancer. HTLV-1 research in the past 35 years has been most revealing in the mechanisms of viral oncogenesis. HTLV-1 establishes a lifelong persistent infection in CD4+ T lymphocytes. The infection outcome is governed by host immunity. ATL develops in 2–5% of infected individuals 30–50 years after initial exposure. HTLV-1 encodes two oncoproteins Tax and HBZ, which are required for initiation of cellular transformation and maintenance of cell proliferation, respectively. HTLV-1 oncogenesis is driven by a clonal selection and expansion process during which both host and viral factors cooperate to impair genome stability, immune surveillance, and other mechanisms of tumor suppression. A better understanding of HTLV-1 biology and leukemogenesis will reveal new strategies and modalities for ATL prevention and treatment.

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References

  1. Poiesz BJ, Ruscetti FW, Gazdar AF, Bunn PA, Minna JD, Gallo RC (1980) Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci U S A 77:7415–7419

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Yoshida M, Miyoshi I, Hinuma Y (1982) Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease. Proc Natl Acad Sci U S A 79:2031–2035

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Matsuoka M, Jeang KT (2011) Human T-cell leukemia virus type 1 (HTLV-1) and leukemic transformation: viral infectivity, Tax, HBZ and therapy. Oncogene 30:1379–1389

    Article  CAS  PubMed  Google Scholar 

  4. Fenizia C, Fiocchi M, Jones K, Parks RW, Ceribelli M, Chevalier SA, Edwards D, Ruscetti F, Pise-Masison CA, Franchini G (2014) Human T-cell leukemia/lymphoma virus type 1 p30, but not p12/p8, counteracts toll-like receptor 3 (TLR3) and TLR4 signaling in human monocytes and dendritic cells. J Virol 88:393–402

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  5. Romeo MM, Ko B, Kim J, Brady R, Heatley HC, He J, Harrod CK, Barnett B, Ratner L, Lairmore MD, Martinez E, Lüscher B, Robson CN, Henriksson M, Harrod R (2015) Acetylation of the c-MYC oncoprotein is required for cooperation with the HTLV-1 p30(II) accessory protein and the induction of oncogenic cellular transformation by p30(II)/c-MYC. Virology 476:271–288

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Pise-Masison CA, de Castro-Amarante MF, Enose-Akahata Y, Buchmann RC, Fenizia C, Washington Parks R, Edwards D, Fiocchi M, Alcantara LC Jr, Bialuk I, Graham J, Walser JC, McKinnon K, Galvão-Castro B, Gessain A, Venzon D, Jacobson S, Franchini G (2014) Co-dependence of HTLV-1 p12 and p8 functions in virus persistence. PLoS Pathog 10:e1004454

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  7. Edwards D, Fukumoto R, de Castro-Amarante MF, Alcantara LC, Galvão-Castro B, Washington Parks R, Pise-Masison C, Franchini G (2014) Palmitoylation and p8-mediated human T-cell leukemia virus type 1 transmission. J Virol 88:2319–2322

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  8. Gaudray G, Gachon F, Basbous J, Biard-Piechaczyk M, Devaux C, Mesnard JM (2002) The complementary strand of the human T-cell leukemia virus type 1 RNA genome encodes a bZIP transcription factor that down-regulates viral transcription. J Virol 76:12813–12822

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Satou Y, Yasunaga J, Yoshida M, Matsuoka M (2006) HTLV-I basic leucine zipper factor gene mRNA supports proliferation of adult T cell leukemia cells. Proc Natl Acad Sci U S A 103:720–725

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Wolfe ND, Heneine W, Carr JK, Garcia AD, Shanmugam V, Tamoufe U, Torimiro JN, Prosser AT, Lebreton M, Mpoudi-Ngole E, McCutchan FE, Birx DL, Folks TM, Burke DS, Switzer WM (2005) Emergence of unique primate T-lymphotropic viruses among central African bushmeat hunters. Proc Natl Acad Sci U S A 102:7994–7999

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Richard L, Mouinga-Ondémé A, Betsem E, Filippone C, Nerrienet E, Kazanji M, Gessain A (2016) Zoonotic transmission of two new strains of human T-lymphotropic virus type 4 in hunters bitten by a gorilla in central Africa. Clin Infect Dis 63:800–803

    Article  PubMed  Google Scholar 

  12. Gessain A, Rua R, Betsem E, Turpin J, Mahieux R (2013) HTLV-3/4 and simian foamy retroviruses in humans: discovery, epidemiology, cross-species transmission and molecular virology. Virology 435:187–199

    Article  CAS  PubMed  Google Scholar 

  13. Panfil AR, Martinez MP, Ratner L, Green PL (2016) Human T-cell leukemia virus-associated malignancy. Curr Opin Virol 20:40–46

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Matsuoka M, Yasunaga J (2013) Human T-cell leukemia virus type 1: replication, proliferation and propagation by Tax and HTLV-1 bZIP factor. Curr Opin Virol 3:684–691

    Article  CAS  PubMed  Google Scholar 

  15. Bangham CR, Ratner L (2015) How does HTLV-1 cause adult T-cell leukaemia/lymphoma (ATL)? Curr Opin Virol 14:93–100

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Giam CZ, Semmes OJ (2016) HTLV-1 infection and adult T-cell leukemia/lymphoma-a tale of two proteins: Tax and HBZ. Virus 8:E161

    Article  CAS  Google Scholar 

  17. Satake M, Yamaguchi K, Tadokoro K (2012) Current prevalence of HTLV-1 in Japan as determined by screening of blood donors. J Med Virol 84:327–335

    Article  PubMed  Google Scholar 

  18. Murphy EL (2016) Infection with human T-lymphotropic virus types-1 and -2 (HTLV-1 and -2): implications for blood transfusion safety. Transfus Clin Biol 23:13–19

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Xie J, Ge S, Zhang Y, Lin Y, Ni H, Zhang J, Chen C (2015) The prevalence of human T-lymphotropic virus infection among blood donors in southeast China, 2004–2013. PLoS Negl Trop Dis 9:e0003685

    Article  PubMed  PubMed Central  Google Scholar 

  20. Du J, Chen C, Gao J, Xie J, Rong X, Xu X, Wang Y, Wang F, Li J, Lu Z, Guo W, Li G, Wang Z, Xu D, Weng J, Zhao Z, Weng W, Li H, Du Y, Li S, Zhen C, Liu B, Guo T (2014) History and update of HTLV infection in China. Virus Res 191:134–137

    Article  CAS  PubMed  Google Scholar 

  21. Zeng Y, Lan X, Wang B, Fan J, Chen W, Yang T, Liang J, Xu X, Wang Y, Sui Y, Hu R, Hinuma Y (1985) Seroepidemiological studies on human T-cell leukemia antibody in China. Chin J Virol 1:344–348

    Google Scholar 

  22. Au WY, Lo JY (2005) HTLV-1-related lymphoma in Hong Kong Chinese. Am J Hematol 78:80–81

    Article  CAS  PubMed  Google Scholar 

  23. Wang CH, Chen CJ, Hu CY, You SL, Chu CT, Chou MJ, Essex M, Blattner WA, Liu CH, Yang CS (1988) Seroepidemiology of human T-cell lymphotropic virus type I infection in Taiwan. Cancer Res 48:5042–5044

    CAS  PubMed  Google Scholar 

  24. Lu SC, Kao CL, Chin LT, Chen JW, Yang CM, Chang JH, Hsu SC, Chang AC, Chen BH (2001) Seroprevalence and demographic characteristics of HTLV-I among blood donors in Taiwan: 1996–1999. Int J Hematol 74:333–337

    Article  CAS  PubMed  Google Scholar 

  25. Cook LB, Taylor GP (2015) Treatment of adult T-cell leukaemia/lymphoma: is the virus a target? Curr Opin Infect Dis 28:583–588

    Article  CAS  PubMed  Google Scholar 

  26. Iwanaga M, Watanabe T, Utsunomiya A, Okayama A, Uchimaru K, Koh KR, Ogata M, Kikuchi H, Sagara Y, Uozumi K, Mochizuki M, Tsukasaki K, Saburi Y, Yamamura M, Tanaka J, Moriuchi Y, Hino S, Kamihira S, Yamaguchi K (2010) Human T-cell leukemia virus type I (HTLV-1) proviral load and disease progression in asymptomatic HTLV-1 carriers: a nationwide prospective study in Japan. Blood 116:1211–1219

    Article  CAS  PubMed  Google Scholar 

  27. Dutartre H, Clavière M, Journo C, Mahieux R (2016) Cell-free versus cell-to-cell infection by human immunodeficiency virus type 1 and human T-lymphotropic virus type 1: exploring the link among viral source, viral trafficking, and viral replication. J Virol 90:7607–7617

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Nagai Y, Kawahara M, Hishizawa M, Shimazu Y, Sugino N, Fujii S, Kadowaki N, Takaori-Kondo A (2015) T memory stem cells are the hierarchical apex of adult T-cell leukemia. Blood 125:3527–3535

    Article  CAS  PubMed  Google Scholar 

  29. Igakura T, Stinchcombe JC, Goon PK, Taylor GP, Weber JN, Griffiths GM, Tanaka Y, Osame M, Bangham CR (2003) Spread of HTLV-I between lymphocytes by virus-induced polarization of the cytoskeleton. Science 299:1713–1716

    Article  CAS  PubMed  Google Scholar 

  30. Nejmeddine M, Bangham CR (2010) The HTLV-1 virological synapse. Virus 2:1427–1447

    Article  CAS  Google Scholar 

  31. Pais-Correia AM, Sachse M, Guadagnini S, Robbiati V, Lasserre R, Gessain A, Gout O, Alcover A, Thoulouze MI (2010) Biofilm-like extracellular viral assemblies mediate HTLV-1 cell-to-cell transmission at virological synapses. Nat Med 16:83–89

    Article  CAS  PubMed  Google Scholar 

  32. Jin DY, Spencer F, Jeang KT (1998) Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1. Cell 93:81–91

    Article  CAS  PubMed  Google Scholar 

  33. Bangham CR (2009) CTL quality and the control of human retroviral infections. Eur J Immunol 39:1700–1712

    Article  CAS  PubMed  Google Scholar 

  34. Nagata K, Ohtani K, Nakamura M, Sugamura K (1989) Activation of endogenous c-fos proto-oncogene expression by human T-cell leukemia virus type I-encoded p40lax protein in the human T cell line, Jurkat. J Virol 63:3220–3226

    CAS  PubMed  PubMed Central  Google Scholar 

  35. Tagaya Y, Taniguchi Y, Naramura M, Okada M, Suzuki N, Kanamori H, Nikaido T, Honjo T, Yodoi J (1987) Transcription of IL-2 receptor gene is stimulated by ATL-derived factor produced by HTLV-I+ T cell lines. Immunol Lett 15:221–228

    Article  CAS  PubMed  Google Scholar 

  36. Sugamura K, Fujii M, Kannagi M, Sakitani M, Takeuchi M, Hinuma Y (1984) Cell surface phenotypes and expression of viral antigens of various human cell lines carrying human T-cell leukemia virus. Int J Cancer 34:221–228

    Article  CAS  PubMed  Google Scholar 

  37. Derse D, Mikovits J, Ruscetti F (1997) X-I and X-II open reading frames of HTLV-I are not required for virus replication or for immortalization of primary T-cells in vitro. Virology 237:123–128

    Google Scholar 

  38. Lairmore MD (2014) Animal models of bovine leukemia virus and human T-lymphotrophic virus type-1: insights in transmission and pathogenesis. Ann Rev Anim Biosci 2:189–208

    Article  CAS  Google Scholar 

  39. Rodríguez SM, Florins A, Gillet N, de Brogniez A, Sánchez-Alcaraz MT, Boxus M, Boulanger F, Gutiérrez G, Trono K, Alvarez I, Vagnoni L, Willems L (2011) Preventive and therapeutic strategies for bovine leukemia virus: lessons for HTLV. Virus 3:1210–1248

    Article  Google Scholar 

  40. Barez PY, de Brogniez A, Carpentier A, Gazon H, Gillet N, Gutiérrez G, Hamaidia M, Jacques JR, Perike S, Neelature Sriramareddy S, Renotte N, Staumont B, Reichert M, Trono K, Willems L (2015) Recent advances in BLV research. Virus 7:6080–6088

    Article  CAS  Google Scholar 

  41. Miura M, Yasunaga J, Tanabe J, Sugata K, Zhao T, Ma G, Miyazato P, Ohshima K, Kaneko A, Watanabe A, Saito A, Akari H, Matsuoka M (2013) Characterization of simian T-cell leukemia virus type 1 in naturally infected Japanese macaques as a model of HTLV-1 infection. Retrovirology 10:118

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  42. Hasegawa H, Sawa H, Lewis MJ, Orba Y, Sheehy N, Yamamoto Y, Ichinohe T, Katano H, Tsunetsugu-Yokota Y, Takahashi H, Matsuda J, Sata T, Kurata T, Nagashima K, Hall WW (2006) Thymus-derived leukemia-lymphoma in mice transgenic for the Tax gene of human T-lymphotropic virus type I. Nat Med 12:466–472

    Article  CAS  PubMed  Google Scholar 

  43. Satou Y, Yasunaga J, Zhao T, Yoshida M, Miyazato P, Takai K, Shimizu K, Ohshima K, Green PL, Ohkura N, Yamaguchi T, Ono M, Sakaguchi S, Matsuoka M (2011) HTLV-1 bZIP factor induces T-cell lymphoma and systemic inflammation in vivo. PLoS Pathog 7:e1001274

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. Zimmerman B, Niewiesk S, Lairmore MD (2010) Mouse models of human T lymphotropic virus type-1-associated adult T-cell leukemia/lymphoma. Vet Pathol 47:677–689

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  45. Shultz LD, Brehm MA, Garcia-Martinez JV, Greiner DL (2012) Humanized mice for immune system investigation: progress, promise and challenges. Nat Rev Immunol 12:786–798

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  46. Legrand N, Ploss A, Balling R, Becker PD, Borsotti C, Brezillon N, Debarry J, de Jong Y, Deng H, Di Santo JP, Eisenbarth S, Eynon E, Flavell RA, Guzman CA, Huntington ND, Kremsdorf D, Manns MP, Manz MG, Mention JJ, Ott M, Rathinam C, Rice CM, Rongvaux A, Stevens S, Spits H, Strick-Marchand H, Takizawa H, van Lent AU, Wang C, Weijer K, Willinger T, Ziegler P (2009) Humanized mice for modeling human infectious disease: challenges, progress, and outlook. Cell Host Microbe 6:5–9

    Article  CAS  PubMed  Google Scholar 

  47. Marsden MD, Zack JA (2015) Studies of retroviral infection in humanized mice. Virology 479–480:297–309

    Article  PubMed  CAS  Google Scholar 

  48. Pérès E, Bagdassarian E, This S, Villaudy J, Rigal D, Gazzolo L, Duc Dodon M (2015) From immunodeficiency to humanization: the contribution of mouse models to explore HTLV-1 leukemogenesis. Virus 7:6371–6386

    Article  CAS  Google Scholar 

  49. Miyazato P, Yasunaga J, Taniguchi Y, Koyanagi Y, Mitsuya H, Matsuoka M (2006) De novo human T-cell leukemia virus type 1 infection of human lymphocytes in NOD-SCID, common γ-chain knockout mice. J Virol 80:10683–10691

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  50. Banerjee P, Crawford L, Samuelson E, Feuer G (2010) Hematopoietic stem cells and retroviral infection. Retrovirology 7:8

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  51. Tie F, Adya N, Greene WC, Giam CZ (1996) Interaction of the human T-lymphotropic virus type 1 Tax dimer with CREB and the viral 21-base-pair repeat. J Virol 70:8368–8374

    CAS  PubMed  PubMed Central  Google Scholar 

  52. Kwok RP, Laurance ME, Lundblad JR, Goldman PS, Shih HM, Connor LM, Marriott SJ, Goodman RH (1996) Control of cAMP-regulated enhancers by the viral transactivator Tax through CREB and the co-activator CBP. Nature 380:642–646

    Article  CAS  PubMed  Google Scholar 

  53. Jin DY, Jeang KT (1997) HTLV-I Tax self-association in optimal trans-activation function. Nucleic Acids Res 25:79–87

    Article  Google Scholar 

  54. Baranger AM, Palmer CR, Hamm MK, Giebler HA, Brauweiler A, Nyborg JK, Schepartz A (1995) Mechanism of DNA-binding enhancement by the human T-cell leukaemia virus transactivator Tax. Nature 376:606–608

    Article  CAS  PubMed  Google Scholar 

  55. Semmes OJ, Jeang KT (1995) Definition of a minimal activation domain in human T-cell leukemia virus type I Tax. J Virol 69:1827–1833

    CAS  PubMed  PubMed Central  Google Scholar 

  56. Ching YP, Chun ACS, Chin KT, Zhang ZQ, Jeang KT, Jin DY (2004) Specific TATAA and bZIP requirements suggest that HTLV-1 Tax has transcriptional activity subsequent to the assembly of an initiation complex. Retrovirology 1:18

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  57. Koga H, Ohshima T, Shimotohno K (2004) Enhanced activation of Tax-dependent transcription of human T-cell leukemia virus type I (HTLV-I) long terminal repeat by TORC3. J Biol Chem 279:52978–52983

    Article  CAS  PubMed  Google Scholar 

  58. Siu YT, Chin KT, Siu KL, Choy EYW, Jeang KT, Jin DY (2006) TORC1 and TORC2 coactivators are required for Tax activation of the human T-cell leukemia virus type 1 long terminal repeats. J Virol 80:7052–7059

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  59. Simonis N, Rual JF, Lemmens I, Boxus M, Hirozane-Kishikawa T, Gatot JS, Dricot A, Hao T, Vertommen D, Legros S, Daakour S, Klitgord N, Martin M, Willaert JF, Dequiedt F, Navratil V, Cusick ME, Burny A, Van Lint C, Hill DE, Tavernier J, Kettmann R, Vidal M, Twizere JC (2012) Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses. Retrovirology 9:26

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  60. Chan CP, Siu YT, Kok KH, Ching YP, Tang HMV, Jin DY (2013) Group I p21-activated kinases facilitate Tax-mediated transcriptional activation of the human T-cell leukemia virus type 1 long terminal repeats. Retrovirology 10:47

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  61. Tang HMV, Gao WW, Chan CP, Siu YT, Wong CM, Kok KH, Ching YP, Takemori H, Jin DY (2013) LKB1 tumor suppressor and salt-inducible kinases negatively regulate human T-cell leukemia virus type 1 transcription. Retrovirology 10:40

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  62. Tang HMV, Gao WW, Chan CP, Cheng Y, Deng JJ, Yuen KS, Iha H, Jin DY (2015) SIRT1 suppresses human T-cell leukemia virus type 1 transcription. J Virol 89:8623–8631

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  63. Ma G, Yasunaga J, Akari H, Matsuoka M (2015) TCF1 and LEF1 act as T-cell intrinsic HTLV-1 antagonists by targeting Tax. Proc Natl Acad Sci U S A 112:2216–2221

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  64. Chan JK, Greene WC (2012) Dynamic roles for NF-κB in HTLV-I and HIV-1 retroviral pathogenesis. Immunol Rev 246:286–310

    Article  PubMed  CAS  Google Scholar 

  65. Jin DY, Giordano V, Kibler KV, Nakano H, Jeang KT (1999) Role of adapter function in oncoprotein-mediated activation of NF-κB. Human T-cell leukemia virus type I Tax interacts directly with IκB kinase γ. J Biol Chem 274 17402–17405

    Google Scholar 

  66. Harhaj EW, Sun SC (1999) IKKγ serves as a docking subunit of the IκB kinase (IKK) and mediates interaction of IKK with the human T-cell leukemia virus Tax protein. J Biol Chem 274:22911–22914

    Article  CAS  PubMed  Google Scholar 

  67. Chu ZL, Shin YA, Yang JM, DiDonato JA, Ballard DW (1999) IKKγ mediates the interaction of cellular IκB kinases with the Tax transforming protein of human T cell leukemia virus type 1. J Biol Chem 274:15297–15300

    Article  CAS  PubMed  Google Scholar 

  68. De Valck D, Jin DY, Heyninck K, Van de Craen M, Contreras R, Fiers W, Jeang KT, Beyaert R (1999) The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases. Oncogene 18:4182–4190

    Article  PubMed  CAS  Google Scholar 

  69. Pujari R, Hunte R, Thomas R, van der Weyden L, Rauch D, Ratner L, Nyborg JK, Ramos JC, Takai Y, Shembade N (2015) Human T-cell leukemia virus type 1 (HTLV-1) Tax requires CADM1/TSLC1 for inactivation of the NF-κB inhibitor A20 and constitutive NF-κB signaling. PLoS Pathog 11:e1004721

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  70. Chin KT, Chun AC, Ching YP, Jeang KT, Jin DY (2007) Human T-cell leukemia virus oncoprotein Tax represses nuclear receptor-dependent transcription by targeting coactivator TAX1BP1. Cancer Res 67:1072–1081

    Article  CAS  PubMed  Google Scholar 

  71. Journo C, Filipe J, About F, Chevalier SA, Afonso PV, Brady JN, Flynn D, Tangy F, Israël A, Vidalain PO, Mahieux R, Weil R (2009) NRP/Optineurin cooperates with TAX1BP1 to potentiate the activation of NF-κB by human T-lymphotropic virus type 1 Tax protein. PLoS Pathog 5:e1000521

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  72. Shembade N, Harhaj NS, Yamamoto M, Akira S, Harhaj EW (2007) The human T-cell leukemia virus type 1 Tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-κB activation. J Virol 81:13735–13742

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  73. Ho YK, Zhi H, Bowlin T, Dorjbal B, Philip S, Zahoor MA, Shih HM, Semmes OJ, Schaefer B, Glover JN, Giam CZ (2015) HTLV-1 Tax stimulates ubiquitin E3 ligase, ring finger protein 8, to assemble lysine 63-linked polyubiquitin chains for TAK1 and IKK activation. PLoS Pathog 11:e1005102

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  74. Lavorgna A, Harhaj EW (2014) Regulation of HTLV-1 Tax stability, cellular trafficking and NF-κB activation by the ubiquitin-proteasome pathway. Virus 6:3925–3943

    Article  CAS  Google Scholar 

  75. Fujii M, Tsuchiya H, Chuhjo T, Akizawa T, Seiki M (1992) Interaction of HTLV-1 Tax1 with p67SRF causes the aberrant induction of cellular immediate early genes through CArG boxes. Genes Dev 6:2066–2076

    Article  CAS  PubMed  Google Scholar 

  76. Winter HY, Marriott SJ (2007) Human T-cell leukemia virus type 1 Tax enhances serum response factor DNA binding and alters site selection. J Virol 81:6089–6098

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  77. Jeang KT, Chiu R, Santos E, Kim SJ (1991) Induction of the HTLV-I LTR by Jun occurs through the Tax-responsive 21-bp elements. Virology 181:218–227

    Article  CAS  PubMed  Google Scholar 

  78. Smith MR, Greene WC (1991) Type I human T cell leukemia virus Tax protein transforms rat fibroblasts through the cyclic adenosine monophosphate response element binding protein/activating transcription factor pathway. J Clin Invest 88:1038–1042

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  79. Grassmann R, Dengler C, Müller-Fleckenstein I, Fleckenstein B, McGuire K, Dokhelar MC, Sodroski JG, Haseltine WA (1989) Transformation to continuous growth of primary human T lymphocytes by human T-cell leukemia virus type I X-region genes transduced by a Herpesvirus saimiri vector. Proc Natl Acad Sci U S A 86:3351–3355

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  80. Soda Y, Jinno A, Tanaka Y, Akagi T, Shimotohno K, Hoshino H (2000) Rapid tumor formation and development of neutrophilia and splenomegaly in nude mice transplanted with human cells expressing human T cell leukemia virus type I or Tax1. Leukemia 14:1467–1476

    Article  CAS  PubMed  Google Scholar 

  81. Siu YT, Jin DY (2007) CREB-a real culprit in oncogenesis. FEBS J 274:3224–3232

    Article  CAS  PubMed  Google Scholar 

  82. Watanabe T (2017) Adult T-cell leukemia: molecular basis for clonal expansion and transformation of HTLV-1-infected T cells. Blood 129:1071–1081

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  83. Reynaud C, Fabre S, Jalinot P (2000) The PDZ protein TIP-1 interacts with the Rho effector rhotekin and is involved in Rho signaling to the serum response element. J Biol Chem 275:33962–33968

    Article  CAS  PubMed  Google Scholar 

  84. Yan P, Fu J, Qu Z, Li S, Tanaka T, Grusby MJ, Xiao G (2009) PDLIM2 suppresses human T-cell leukemia virus type I Tax-mediated tumorigenesis by targeting Tax into the nuclear matrix for proteasomal degradation. Blood 113:4370–4380

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  85. Makokha GN, Takahashi M, Higuchi M, Saito S, Tanaka Y, Fujii M (2013) Human T-cell leukemia virus type 1 Tax protein interacts with and mislocalizes the PDZ domain protein MAGI-1. Cancer Sci 104:313–320

    Article  CAS  PubMed  Google Scholar 

  86. Chun ACS, Zhou Y, Wong CM, Kung HF, Jeang KT, Jin DY (2000) Coiled-coil motif as a structural basis for the interaction of HTLV type 1 Tax with cellular cofactors. AIDS Res Hum Retrovir 16:1689–1694

    Article  CAS  PubMed  Google Scholar 

  87. Jin DY, Teramoto H, Giam CZ, Chun RF, Gutkind JS, Jeang KT (1997) A human suppressor of c-Jun N-terminal kinase 1 activation by tumor necrosis factor α. J Biol Chem 272:25816–25823

    Article  CAS  PubMed  Google Scholar 

  88. Ching YP, Chan SF, Jeang KT, Jin DY (2006) The retroviral oncoprotein Tax targets the coiled-coil centrosomal protein TAX1BP2 to induce centrosome overduplication. Nat Cell Biol 8:717–724

    Article  CAS  PubMed  Google Scholar 

  89. Arnold J, Yamamoto B, Li M, Phipps AJ, Younis I, Lairmore MD, Green PL (2006) Enhancement of infectivity and persistence in vivo by HBZ, a natural antisense coded protein of HTLV-1. Blood 107:3976–3982

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  90. Valeri VW, Hryniewicz A, Andresen V, Jones K, Fenizia C, Bialuk I, Chung HK, Fukumoto R, Parks RW, Ferrari MG, Nicot C, Cecchinato V, Ruscetti F, Franchini G (2010) Requirement of the human T-cell leukemia virus p12 and p30 products for infectivity of human dendritic cells and macaques but not rabbits. Blood 116:3809–3817

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  91. Mitobe Y, Yasunaga J, Furuta R, Matsuoka M (2015) HTLV-1 bZIP factor RNA and protein impart distinct functions on T-cell proliferation and survival. Cancer Res 75:4143–4152

    Article  CAS  PubMed  Google Scholar 

  92. Zhao T (2016) The role of HBZ in HTLV-1-induced oncogenesis. Virus 8:E34

    Article  CAS  Google Scholar 

  93. Ma G, Yasunaga J, Matsuoka M (2016) Multifaceted functions and roles of HBZ in HTLV-1 pathogenesis. Retrovirology 13:16

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  94. Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144:646–674

    Article  CAS  PubMed  Google Scholar 

  95. Ma G, Yasunaga J, Fan J, Yanagawa S, Matsuoka M (2013) HTLV-1 bZIP factor dysregulates the Wnt pathways to support proliferation and migration of adult T-cell leukemia cells. Oncogene 32:4222–4230

    Article  CAS  PubMed  Google Scholar 

  96. Zane L, Yasunaga J, Mitagami Y, Yedavalli V, Tang SW, Chen CY, Ratner L, Lu X, Jeang KT (2012) Wip1 and p53 contribute to HTLV-1 Tax-induced tumorigenesis. Retrovirology 9:114

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  97. Neuveut C, Low KG, Maldarelli F, Schmitt I, Majone F, Grassmann R, Jeang KT (1998) Human T-cell leukemia virus type 1 Tax and cell cycle progression: role of cyclin D-cdk and p110Rb. Mol Cell Biol 18:3620–3632

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  98. Kehn K, Fuente Cde L, Strouss K, Berro R, Jiang H, Brady J, Mahieux R, Pumfery A, Bottazzi ME, Kashanchi F (2005) The HTLV-I Tax oncoprotein targets the retinoblastoma protein for proteasomal degradation. Oncogene 24:525–540

    Article  CAS  PubMed  Google Scholar 

  99. Tanaka-Nakanishi A, Yasunaga J, Takai K, Matsuoka M (2014) HTLV-1 bZIP factor suppresses apoptosis by attenuating the function of FoxO3a and altering its localization. Cancer Res 74:188–200

    Article  CAS  PubMed  Google Scholar 

  100. Yuen CK, Chan CP, Fung SY, Wang PH, Wong WM, Tang HMV, Yuen KS, Chan CP, Jin DY, Kok KH (2016) Suppression of type I interferon production by human T-cell leukemia virus type 1 oncoprotein Tax through inhibition of IRF3 phosphorylation. J Virol 90:3902–3912

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  101. Yasuma K, Yasunaga J, Takemoto K, Sugata K, Mitobe Y, Takenouchi N, Nakagawa M, Suzuki Y, Matsuoka M (2016) HTLV-1 bZIP factor impairs anti-viral immunity by inducing co-inhibitory molecule, T cell immunoglobulin and ITIM domain (TIGIT). PLoS Pathog 12:e1005372

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  102. Belgnaoui SM, Fryrear KA, Nyalwidhe JO, Guo X, Semmes OJ (2010) The viral oncoprotein Tax sequesters DNA damage response factors by tethering MDC1 to chromatin. J Biol Chem 285:32897–32905

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  103. Dayaram T, Lemoine FJ, Donehower LA, Marriott SJ (2013) Activation of WIP1 phosphatase by HTLV-1 Tax mitigates the cellular response to DNA damage. PLoS One 8:e55989

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  104. Chaib-Mezrag H, Lemaçon D, Fontaine H, Bellon M, Bai XT, Drac M, Coquelle A, Nicot C (2014) Tax impairs DNA replication forks and increases DNA breaks in specific oncogenic genome regions. Mol Cancer 13:205

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  105. Baydoun HH, Cherian MA, Green P, Ratner L (2015) Inducible nitric oxide synthase mediates DNA double strand breaks in human T-cell leukemia virus type 1-induced leukemia/lymphoma. Retrovirology 12:71

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  106. Kuhlmann AS, Villaudy J, Gazzolo L, Castellazzi M, Mesnard JM, Duc Dodon M (2007) HTLV-1 HBZ cooperates with JunD to enhance transcription of the human telomerase reverse transcriptase gene (hTERT). Retrovirology 4:92

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  107. Zhao T, Satou Y, Sugata K, Miyazato P, Green PL, Imamura T, Matsuoka M (2011) HTLV-1 bZIP factor enhances TGF-β signaling through p300 coactivator. Blood 118:1865–1876

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  108. Mitagami Y, Yasunaga J, Kinosada H, Ohshima K, Matsuoka M (2015) Interferon-γ promotes inflammation and development of T-cell lymphoma in HTLV-1 bZIP factor transgenic mice. PLoS Pathog 11:e1005120

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  109. Miyazato P, Matsuo M, Katsuya H, Satou Y (2016) Transcriptional and epigenetic regulatory mechanisms affecting HTLV-1 provirus. Viruses 8:E171

    Article  PubMed  CAS  Google Scholar 

  110. Rowan AG, Suemori K, Fujiwara H, Yasukawa M, Tanaka Y, Taylor GP, Bangham CR (2014) Cytotoxic T lymphocyte lysis of HTLV-1 infected cells is limited by weak HBZ protein expression, but non-specifically enhanced on induction of Tax expression. Retrovirology 11:116

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  111. Satou Y, Miyazato P, Ishihara K, Yaguchi H, Melamed A, Miura M, Fukuda A, Nosaka K, Watanabe T, Rowan AG, Nakao M, Bangham CR (2016) The retrovirus HTLV-1 inserts an ectopic CTCF-binding site into the human genome. Proc Natl Acad Sci U S A 113:3054305–3054309

    Article  CAS  Google Scholar 

  112. Cook LB, Melamed A, Niederer H, Valganon M, Laydon D, Foroni L, Taylor GP, Matsuoka M, Bangham CR (2014) The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood 123:3925–3931

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  113. Sugata K, Yasunaga J, Mitobe Y, Miura M, Miyazato P, Kohara M, Matsuoka M (2015) Protective effect of cytotoxic T lymphocytes targeting HTLV-1 bZIP factor. Blood 126:1095–1105

    Article  CAS  PubMed  Google Scholar 

  114. Kuo YL, Giam CZ (2006) Activation of the anaphase promoting complex by HTLV-1 Tax leads to senescence. EMBO J 25:1741–1752

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  115. Melamed A, Laydon DJ, Gillet NA, Tanaka Y, Taylor GP, Bangham CR (2013) Genome-wide determinants of proviral targeting, clonal abundance and expression in natural HTLV-1 infection. PLoS Pathog 9:e1003271

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  116. Melamed A, Witkover AD, Laydon DJ, Brown R, Ladell K, Miners K, Rowan AG, Gormley N, Price DA, Taylor GP, Murphy EL, Bangham CR (2014) Clonality of HTLV-2 in natural infection. PLoS Pathog 10:e1004006

    Article  PubMed  PubMed Central  Google Scholar 

  117. Kataoka K, Nagata Y, Kitanaka A, Shiraishi Y, Shimamura T, Yasunaga J, Totoki Y, Chiba K, Sato-Otsubo A, Nagae G, Ishii R, Muto S, Kotani S, Watatani Y, Takeda J, Sanada M, Tanaka H, Suzuki H, Sato Y, Shiozawa Y, Yoshizato T, Yoshida K, Makishima H, Iwanaga M, Ma G, Nosaka K, Hishizawa M, Itonaga H, Imaizumi Y, Munakata W, Ogasawara H, Sato T, Sasai K, Muramoto K, Penova M, Kawaguchi T, Nakamura H, Hama N, Shide K, Kubuki Y, Hidaka T, Kameda T, Nakamaki T, Ishiyama K, Miyawaki S, Yoon SS, Tobinai K, Miyazaki Y, Takaori-Kondo A, Matsuda F, Takeuchi K, Nureki O, Aburatani H, Watanabe T, Shibata T, Matsuoka M, Miyano S, Shimoda K, Ogawa S (2015) Integrated molecular analysis of adult T cell leukemia/lymphoma. Nat Genet 47:1304–1315

    Article  CAS  PubMed  Google Scholar 

  118. Yeh CH, Bellon M, Pancewicz-Wojtkiewicz J, Nicot C (2016) Oncogenic mutations in the FBXW7 gene of adult T-cell leukemia patients. Proc Natl Acad Sci U S A 113:6731–6736

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  119. Moles R, Nicot C (2015) The emerging role of miRNAs in HTLV-1 infection and ATLL pathogenesis. Viruses 7:4047–4074

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  120. Kato K, Akashi K (2015) Recent advances in therapeutic approaches for adult T-cell leukemia/lymphoma. Viruses 7:6604–6612

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  121. Nasr R, Marçais A, Hermine O, Bazarbachi A (2017) Overview of targeted therapies for adult T-cell leukemia/lymphoma. Methods Mol Biol 1582:197–216

    Article  PubMed  Google Scholar 

  122. Hermine O, Bouscary D, Gessain A, Turlure P, Leblond V, Franck N, Buzyn-Veil A, Rio B, Macintyre E, Dreyfus F, Bazarbachi A (1995) Treatment of adult T-cell leukemia-lymphoma with zidovudine and interferon α. N Engl J Med 332:1749–1751

    Article  CAS  PubMed  Google Scholar 

  123. Bazarbachi A, Plumelle Y, Carlos Ramos J, Tortevoye P, Otrock Z, Taylor G, Gessain A, Harrington W, Panelatti G, Hermine O (2010) Meta-analysis on the use of zidovudine and interferon-alfa in adult T-cell leukemia/lymphoma showing improved survival in the leukemic subtypes. J Clin Oncol 28:4177–4183

    Article  CAS  PubMed  Google Scholar 

  124. Ishida T, Joh T, Uike N, Yamamoto K, Utsunomiya A, Yoshida S, Saburi Y, Miyamoto T, Takemoto S, Suzushima H, Tsukasaki K, Nosaka K, Fujiwara H, Ishitsuka K, Inagaki H, Ogura M, Akinaga S, Tomonaga M, Tobinai K, Ueda R (2012) Defucosylated anti-CCR4 monoclonal antibody (KW-0761) for relapsed adult T-cell leukemia-lymphoma: a multicenter phase II study. J Clin Oncol 30:837–842

    Article  CAS  PubMed  Google Scholar 

  125. Sugata K, Yasunaga J, Kinosada H, Mitobe Y, Furuta R, Mahgoub M, Onishi C, Nakashima K, Ohshima K, Matsuoka M (2016) HTLV-1 viral factor HBZ induces CCR4 to promote T-cell migration and proliferation. Cancer Res 76:5068–5079

    Article  CAS  PubMed  Google Scholar 

  126. Ishida T, Utsunomiya A, Iida S, Inagaki H, Takatsuka Y, Kusumoto S, Takeuchi G, Shimizu S, Ito M, Komatsu H, Wakita A, Eimoto T, Matsushima K, Ueda R (2003) Clinical significance of CCR4 expression in adult T-cell leukemia/lymphoma: its close association with skin involvement and unfavorable outcome. Clin Cancer Res 9:3625–3634

    CAS  PubMed  Google Scholar 

  127. Kreitman RJ, Stetler-Stevenson M, Jaffe ES, Conlon KC, Steinberg SM, Wilson W, Waldmann TA, Pastan I (2016) Complete remissions of adult T-cell leukemia with anti-CD25 recombinant immunotoxin LMB-2 and chemotherapy to block immunogenicity. Clin Cancer Res 22:310–318

    Article  CAS  PubMed  Google Scholar 

  128. Willems L, Hasegawa H, Accolla R, Bangham C, Bazarbachi A, Bertazzoni U, Carneiro-Proietti AB, Cheng H, Chieco-Bianchi L, Ciminale V, Coelho-Dos-Reis J, Esparza J, Gallo RC, Gessain A, Gotuzzo E, Hall W, Harford J, Hermine O, Jacobson S, Macchi B, Macpherson C, Mahieux R, Matsuoka M, Murphy E, Peloponese JM, Simon V, Tagaya Y, Taylor GP, Watanabe T, Yamano Y (2017) Reducing the global burden of HTLV-1 infection: an agenda for research and action. Antivir Res 137:41–48

    Google Scholar 

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Acknowledgments

Our research was supported by SK Yee Medical Research Fund (2001) and Hong Kong Research Grants Council (C7011-15R).

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Authors and Affiliations

  1. School of Biomedical Sciences, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong

    Chi-Ping Chan & Dong-Yan Jin

  2. Department of Microbiology, The University of Hong Kong, 145 Pokfulam Road, Pokfulam, Hong Kong

    Kin-Hang Kok

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  1. Chi-Ping Chan
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Correspondence to Dong-Yan Jin .

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  1. Key Laboratory of Medical Molecular Virology (Ministries of Education and Health), School of Basic Medical Science Fudan University, Shanghai, China

    Qiliang Cai

  2. Key Laboratory of Medical Molecular Virology (Ministries of Education and Health), School of Basic Medical Science Fudan University, Shanghai, China

    Zhenghong Yuan

  3. State Key Laboratory of Virology, College of Life Science, Wuhan University, Wuhan, China

    Ke Lan

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Chan, CP., Kok, KH., Jin, DY. (2017). Human T-Cell Leukemia Virus Type 1 Infection and Adult T-Cell Leukemia. In: Cai, Q., Yuan, Z., Lan, K. (eds) Infectious Agents Associated Cancers: Epidemiology and Molecular Biology. Advances in Experimental Medicine and Biology, vol 1018. Springer, Singapore. https://doi.org/10.1007/978-981-10-5765-6_9

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