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Gastric Non-Helicobacter pylori Helicobacter: Its Significance in Human Gastric Diseases

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Helicobacter pylori

Abstract

In the post-H. pylori eradication era, the clinical significance of gastric non-H. pylori helicobacters (NHPH; also referred to as H. heilmannii-like organisms and H. heilmannii sensu lato) is gradually increasing. This group of bacteria may inhabit the stomach of domestic and wild animals including cats, dogs, pigs, primates, rodents, cheetahs, and rabbits. NHPH are zoonotic microorganisms, meaning that they may transmit between animals and humans. They may be distinguished from H. pylori regarding their microbiology involving larger cells with more distinct spiral shape and bipolarity, localization in the stomach layer and regional distribution, urease activity and virulence factors, and relation to gastric diseases where gastric NHPH infection is often associated with milder gastritis than H. pylori but higher risk of gastric MALT lymphoma. At present, pure culture of NHPH species remains a challenge, but the full genome sequences of some of the species have been reported. Recent and ongoing prevalence studies indicate a higher clinical relevance of these bacteria than earlier impressions suggested. Current efforts in improving cultivation and detection methodology are contributing to an increased understanding of their microbiology, prevalence, and relevance to human diseases.

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Authors and Affiliations

  1. Division of Pathophysiology, Research and Education Center for Clinical Pharmacy, School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, 108-8641, Tokyo, Japan

    Masahiko Nakamura, Anders Øverby & Tetsufumi Takahashi

  2. School of Pharmacy, Nihon University, Funabashi-shi, Chiba, Japan

    Somay Y. Murayama

  3. Medical Education Center, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Tokyo, Japan

    Hidekazu Suzuki

  4. 3rd Department of Internal Medicine, Kyorin University, Mitaka, Tokyo, Japan

    Shinichi Takahashi

  5. Kitasato Institute for Life Sciences, Kitasato University, Minato-ku, Tokyo, Japan

    Hidenori Matsui

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  1. Masahiko Nakamura
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  2. Anders Øverby
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  3. Somay Y. Murayama
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  4. Hidekazu Suzuki
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  5. Tetsufumi Takahashi
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Correspondence to Masahiko Nakamura .

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Editors and Affiliations

  1. Medical Education Center, Keio University School of Medicine, Tokyo, Japan

    Hidekazu Suzuki

  2. The Royal Perth Hospital, The University of Western Australia and, Western Australia, West Australia, Australia

    Robin Warren

  3. The Royal Perth Hospital, The University of Western Australia and, Western Australia, Australia

    Barry Marshall

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Nakamura, M. et al. (2016). Gastric Non-Helicobacter pylori Helicobacter: Its Significance in Human Gastric Diseases. In: Suzuki, H., Warren, R., Marshall, B. (eds) Helicobacter pylori. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55705-0_8

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  • DOI: https://doi.org/10.1007/978-4-431-55705-0_8

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