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Nutritional Deficiencies and Hyperhomocysteinemia

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Nutritional Management and Metabolic Aspects of Hyperhomocysteinemia

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Abstract

Homocysteine is a non-essential amino acid that is developed during the biosynthesis and metabolism of methionine. In methionine metabolic pathway, homocysteine either can be irreversibly degraded to cysteine via the trans-sulfuration pathway or re-methylated back to methionine [1]. Although homocysteine is not directly participating in protein synthesis, its role in folate metabolism and choline catabolism is vital to regulating methionine activity. Methionine is required for the synthesis of many types of proteins, in which its ability to donate methyl groups is essential for the synthesis of methylated compounds, while the inorganic sulfate is fundamental for the synthesis of sulfur-containing amino acids. Polyamines can be synthesized from carbon skeleton of methionine [2].

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  1. Nutrition Department, High Institute of Public Health, Alexandria, Egypt

    Samar Abd El Mohsen Ali

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  1. Food Science and Nutrition, Sultan Qaboos University, Alkhod, Oman

    Mostafa I. Waly

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Ali, S.A.E.M. (2021). Nutritional Deficiencies and Hyperhomocysteinemia. In: Waly, M.I. (eds) Nutritional Management and Metabolic Aspects of Hyperhomocysteinemia. Springer, Cham. https://doi.org/10.1007/978-3-030-57839-8_21

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  • DOI: https://doi.org/10.1007/978-3-030-57839-8_21

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