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Stereotactic Radiosurgery and Radiotherapy in the Management of High-Grade Gliomas

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Principles and Practice of Stereotactic Radiosurgery

Abstract

Despite intermittent waves of enthusiasm regarding varied treatment modalities, high-grade glioma (HGG) remains a highly lethal cancer for which the expected survival has only modestly improved over the past 50 years. Although infiltrative HGG does not present the most rational target for sharply defined single fraction radiosurgery (SRS), the local nature of the disease has encouraged clinicians and researchers to apply focused radiation as initial dose escalation or palliation of recurrences. This chapter documents the history of stereotactic radiation for HGG, selected published results, the technical application of focused radiation, and future directions in the field. The chapter concludes that the best current evidence does not support an improvement in outcome from the use of SRS for primary HGG, but that, for a very select group of patients with recurrent disease, SRS or fractionated stereotactic radiation may represent a safe, reasonable but palliative treatment. For recurrent HGG other treatment modalities have been tested in phase III trials and only such prospective investigation will define the exact role of stereotactic radiation in the salvage setting.

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References

  1. Surawicz TS, McCarthy BJ, Kupelian V, Jukich PJ, Bruner JM, Davis FG. Descriptive epidemiology of primary brain and CNS tumors: results from the Central Brain Tumor Registry of the United States, 1990–1994. Neuro Oncol. 1999;1(1):14–25.

    PubMed Central  CAS  PubMed  Google Scholar 

  2. Melendon R, EC H, editors. Long term survival after treatment of glioblstoma multiforme: is it overstated. 44th Annual Meeting of the American Society for Therapeutic Radiology and Oncology (ASTRO); 2002.

    Google Scholar 

  3. Scott JN, Rewcastle NB, Brasher PM, Fulton D, MacKinnon JA, Hamilton M, et al. Which glioblastoma multiforme patient will become a long-term survivor? A population-based study. Ann Neurol. 1999;46(2):183–8.

    Article  CAS  PubMed  Google Scholar 

  4. Curran Jr WJ, Scott CB, Horton J, Nelson JS, Weinstein AS, Fischbach AJ, et al. Recursive partitioning analysis of prognostic factors in three Radiation Therapy Oncology Group malignant glioma trials. J Natl Cancer Inst. 1993;85(9):704–10.

    Article  PubMed  Google Scholar 

  5. Rao RD, James CD. Altered molecular pathways in gliomas: an overview of clinically relevant issues. Semin Oncol. 2004;31(5): 595–604.

    Article  CAS  PubMed  Google Scholar 

  6. Kitange GJ, Templeton KL, Jenkins RB. Recent advances in the molecular genetics of primary gliomas. Curr Opin Oncol. 2003;15(3):197–203.

    Article  CAS  PubMed  Google Scholar 

  7. Lai A, Kharbanda S, Pope WB, Tran A, Solis OE, Peale F, et al. Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin. J Clin Oncol. 2011;29(34):4482–90. Epub 2011/10/26.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  8. Wallner KE, Galicich JH, Krol G, Arbit E, Malkin MG. Patterns of failure following treatment for glioblastoma multiforme and anaplastic astrocytoma. Int J Radiat Oncol Biol Phys. 1989;16(6): 1405–9.

    Article  CAS  PubMed  Google Scholar 

  9. Hochberg FH, Pruitt A. Assumptions in the radiotherapy of glioblastoma. Neurology. 1980;30(9):907–11.

    Article  CAS  PubMed  Google Scholar 

  10. Cerame MA, Guthikonda M, Kohli CM. Extraneural metastases in gliosarcoma: a case report and review of the literature. Neurosurgery. 1985;17(3):413–8.

    Article  CAS  PubMed  Google Scholar 

  11. Erlich SS, Davis RL. Spinal subarachnoid metastasis from primary intracranial glioblastoma multiforme. Cancer. 1978;42(6):2854–64.

    Article  CAS  PubMed  Google Scholar 

  12. Bailey P, Cushing H. Classification of the tumors of the glioma group on a histogenetic basis with a correlation study of prognosis. Philadelphia: Lippincott; 1926. 175 p.

    Google Scholar 

  13. Elvidge A, Wilder P, Cone W. The gliomas of the central nervous system. Res Publ Ass Nerv Ment Dis. 1937;16:107–81.

    Google Scholar 

  14. Netsky MG, August B, Fowler W. The longevity of patients with glioblastoma multiforme. J Neurosurg. 1950;7(3):261–9.

    Article  CAS  PubMed  Google Scholar 

  15. Bush E, Christensen E. Three Types of Glioblastoma. J Neurosurg. 1947;4(3):200–20.

    Article  Google Scholar 

  16. Kristiansen K, Hagen S, Kollevold T, Torvik A, Holme I, Nesbakken R, et al. Combined modality therapy of operated astrocytomas grade III and IV. Confirmation of the value of postoperative irradiation and lack of potentiation of bleomycin on survival time: a prospective multicenter trial of the Scandinavian Glioblastoma Study Group. Cancer. 1981;47(4):649–52.

    Article  CAS  PubMed  Google Scholar 

  17. Walker MD, Alexander Jr E, Hunt WE, MacCarty CS, Mahaley Jr MS, Mealey Jr J, et al. Evaluation of BCNU and/or radiotherapy in the treatment of anaplastic gliomas. A cooperative clinical trial. J Neurosurg. 1978;49(3):333–43.

    Article  CAS  PubMed  Google Scholar 

  18. Fine HA, Dear KB, Loeffler JS, Black PM, Canellos GP. Meta-analysis of radiation therapy with and without adjuvant chemotherapy for malignant gliomas in adults. Cancer. 1993;71(8):2585–97.

    Article  CAS  PubMed  Google Scholar 

  19. Glioma Meta-Analysis Trialists (GMT) Group. Chemotherapy for high-grade glioma. Cochrane Database Syst Rev. 2002;4, CD003913.

    Google Scholar 

  20. Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 2005;352(10):987–96.

    Article  CAS  PubMed  Google Scholar 

  21. Zietman AL, Suit HD, Tomkinson KN, Thames HD, Sedlacek RS. The response of two human tumor xenografts to fractionated irradiation. The derivation of alpha/beta ratios from growth delay, tumor control, and in vitro cell survival assays. Int J Radiat Oncol Biol Phys. 1990;18(3):569–75.

    Article  CAS  PubMed  Google Scholar 

  22. Marin LA, Smith CE, Langston MY, Quashie D, Dillehay LE. Response of glioblastoma cell lines to low dose rate irradiation. Int J Radiat Oncol Biol Phys. 1991;21(2):397–402.

    Article  CAS  PubMed  Google Scholar 

  23. Raza SM, Lang FF, Aggarwal BB, Fuller GN, Wildrick DM, Sawaya R. Necrosis and glioblastoma: a friend or a foe? A review and a hypothesis. Neurosurgery. 2002;51(1):2–12; discussion12–3.

    Article  PubMed  Google Scholar 

  24. Loeffler JS, Alexander 3rd E, Hochberg FH, Wen PY, Morris JH, Schoene WC, et al. Clinical patterns of failure following stereotactic interstitial irradiation for malignant gliomas. Int J Radiat Oncol Biol Phys. 1990;19(6):1455–62.

    Article  CAS  PubMed  Google Scholar 

  25. Gutin PH, Prados MD, Phillips TL, Wara WM, Larson DA, Leibel SA, et al. External irradiation followed by an interstitial high activity iodine-125 implant “boost” in the initial treatment of malignant gliomas: NCOG study 6G-82–2. Int J Radiat Oncol Biol Phys. 1991;21(3):601–6.

    Article  CAS  PubMed  Google Scholar 

  26. Walker MD, Strike TA, Sheline GE. An analysis of dose-effect relationship in the radiotherapy of malignant gliomas. Int J Radiat Oncol Biol Phys. 1979;5(10):1725–31.

    Article  CAS  PubMed  Google Scholar 

  27. Bleehen NM, Stenning SP. A Medical Research Council trial of two radiotherapy doses in the treatment of grades 3 and 4 astrocytoma. The Medical Research Council Brain Tumour Working Party. Br J Cancer. 1991;64(4):769–74.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  28. Gutin PH, Leibel SA, Wara WM, Choucair A, Levin VA, Philips TL, et al. Recurrent malignant gliomas: survival following interstitial brachytherapy with high-activity iodine-125 sources. J Neurosurg. 1987;67(6):864–73.

    Article  CAS  PubMed  Google Scholar 

  29. Florell RC, Macdonald DR, Irish WD, Bernstein M, Leibel SA, Gutin PH, et al. Selection bias, survival, and brachytherapy for glioma. J Neurosurg. 1992;76(2):179–83.

    Article  CAS  PubMed  Google Scholar 

  30. Shapiro WR, Green SB, Burger PC. A randomized trial of interstitial radiotherapy (IRT) boost for the treatment of newly disgnosed malignant glioma (glioblastoma multiforme, anaplastic astrocytoma, anaplastic oligodendroglioma, malignant mixed glioma): BTCG Study 8701. Neurology. 1994;44 Suppl 2:A263.

    Google Scholar 

  31. Laperriere NJ, Leung PM, McKenzie S, Milosevic M, Wong S, Glen J, et al. Randomized study of brachytherapy in the initial management of patients with malignant astrocytoma. Int J Radiat Oncol Biol Phys. 1998;41(5):1005–11.

    Article  CAS  PubMed  Google Scholar 

  32. Colombo F, Benedetti A, Pozza F, Avanzo RC, Marchetti C, Chierego G, et al. External stereotactic irradiation by linear accelerator. Neurosurgery. 1985;16(2):154–60.

    Article  CAS  PubMed  Google Scholar 

  33. Smith KA, Ashby LS, Gonzalez LF, Brachman DG, Thomas T, Coons SW, et al. Prospective trial of gross-total resection with Gliadel wafers followed by early postoperative Gamma Knife radiosurgery and conformal fractionated radiotherapy as the initial treatment for patients with radiographically suspected, newly diagnosed glioblastoma multiforme. J Neurosurg. 2008;109(Suppl):106–17. Epub 2009/01/10.

    PubMed  Google Scholar 

  34. Shaw E, Scott C, Souhami L, Dinapoli R, Bahary JP, Kline R, et al. Radiosurgery for the treatment of previously irradiated recurrent primary brain tumors and brain metastases: initial report of radiation therapy oncology group protocol (90–05). Int J Radiat Oncol Biol Phys. 1996;34(3):647–54.

    Article  CAS  PubMed  Google Scholar 

  35. Willner J, Flentje M, Bratengeier K. CT simulation in stereotactic brain radiotherapy–analysis of isocenter reproducibility with mask fixation. Radiother Oncol. 1997;45(1):83–8.

    Article  CAS  PubMed  Google Scholar 

  36. Alheit H, Dornfeld S, Dawel M, Alheit M, Henzel B, Steckler K, et al. Patient position reproducibility in fractionated stereotactically guided conformal radiotherapy using the BrainLab mask system. Strahlenther Onkol. 2001;177(5):264–8.

    Article  CAS  PubMed  Google Scholar 

  37. Glass J, Silverman CL, Axelrod R, Corn BW, Andrews DW. Fractionated stereotactic radiotherapy with cis-platinum radiosensitization in the treatment of recurrent, progressive, or persistent malignant astrocytoma. Am J Clin Oncol. 1997;20(3):226–9.

    Article  CAS  PubMed  Google Scholar 

  38. Shepherd SF, Laing RW, Cosgrove VP, Warrington AP, Hines F, Ashley SE, et al. Hypofractionated stereotactic radiotherapy in the management of recurrent glioma. Int J Radiat Oncol Biol Phys. 1997;37(2):393–8.

    Article  CAS  PubMed  Google Scholar 

  39. Hudes RS, Corn BW, Werner-Wasik M, Andrews D, Rosenstock J, Thoron L, et al. A phase I dose escalation study of hypofractionated stereotactic radiotherapy as salvage therapy for persistent or recurrent malignant glioma. Int J Radiat Oncol Biol Phys. 1999;43(2):293–8.

    Article  CAS  PubMed  Google Scholar 

  40. Lederman G, Wronski M, Arbit E, Odaimi M, Wertheim S, Lombardi E, et al. Treatment of recurrent glioblastoma multiforme using fractionated stereotactic radiosurgery and concurrent paclitaxel. Am J Clin Oncol. 2000;23(2):155–9.

    Article  CAS  PubMed  Google Scholar 

  41. Regine WF, Patchell RA, Strottmann JM, Meigooni A, Sanders M, Young AB. Preliminary report of a phase I study of combined fractionated stereotactic radiosurgery and conventional external beam radiation therapy for unfavorable gliomas. Int J Radiat Oncol Biol Phys. 2000;48(2):421–6.

    Article  CAS  PubMed  Google Scholar 

  42. Regine WF, Patchell RA, Strottmann JM, Meigooni A, Sanders M, Young B. Combined stereotactic split-course fractionated gamma knife radiosurgery and conventional radiation therapy for unfavorable gliomas: a phase I study. J Neurosurg. 2000;93 Suppl 3:37–41.

    PubMed  Google Scholar 

  43. Baumert BG, Lutterbach J, Bernays R, Davis JB, Heppner FL. Fractionated stereotactic radiotherapy boost after post-operative radiotherapy in patients with high-grade gliomas. Radiother Oncol. 2003;67(2):183–90.

    Article  PubMed  Google Scholar 

  44. Cho KH, Hall WA, Lo SS, Dusenbery KE. Stereotactic radiosurgery versus fractionated stereotactic radiotherapy boost for patients with glioblastoma multiforme. Technol Cancer Res Treat. 2004;3(1):41–9.

    Article  PubMed  Google Scholar 

  45. Vordermark D, Kolbl O, Ruprecht K, Vince GH, Bratengeier K, Flentje M. Hypofractionated stereotactic re-irradiation: treatment option in recurrent malignant glioma. BMC Cancer. 2005;5:55. Epub 2005/06/01.

    Article  PubMed Central  PubMed  Google Scholar 

  46. Cardinale R, Won M, Choucair A, Gillin M, Chakravarti A, Schultz C, et al. A phase II trial of accelerated radiotherapy using weekly stereotactic conformal boost for supratentorial glioblastoma multiforme: RTOG 0023. Int J Radiat Oncol Biol Phys. 2006;65(5):1422–8. Epub 2006/06/06.

    Article  PubMed  Google Scholar 

  47. Schwer AL, Damek DM, Kavanagh BD, Gaspar LE, Lillehei K, Stuhr K, et al. A phase I dose-escalation study of fractionated stereotactic radiosurgery in combination with gefitinib in patients with recurrent malignant gliomas. Int J Radiat Oncol Biol Phys. 2008;70(4):993–1001. Epub 2007/10/31.

    Article  CAS  PubMed  Google Scholar 

  48. Fokas E, Wacker U, Gross MW, Henzel M, Encheva E, Engenhart-Cabillic R. Hypofractionated stereotactic reirradiation of recurrent glioblastomas : a beneficial treatment option after high-dose radiotherapy? Strahlenther Onkol. 2009;185(4):235–40. Epub 2009/04/17.

    Article  PubMed  Google Scholar 

  49. Gutin PH, Iwamoto FM, Beal K, Mohile NA, Karimi S, Hou BL, et al. Safety and efficacy of bevacizumab with hypofractionated stereotactic irradiation for recurrent malignant gliomas. Int J Radiat Oncol Biol Phys. 2009;75(1):156–63. Epub 2009/01/27.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  50. Fields EC, Damek D, Gaspar LE, Liu AK, Kavanagh BD, Waziri A, et al. Phase I dose escalation trial of vandetanib with fractionated radiosurgery in patients with recurrent malignant gliomas. Int J Radiat Oncol Biol Phys. 2012;82(1):51–7. Epub 2010/11/03.

    Article  PubMed  Google Scholar 

  51. Larson DA, Prados M, Lamborn KR, Smith V, Sneed PK, Chang S, et al. Phase II study of high central dose Gamma Knife radiosurgery and marimastat in patients with recurrent malignant glioma. Int J Radiat Oncol Biol Phys. 2002;54(5):1397–404.

    Article  PubMed  Google Scholar 

  52. Kondziolka D, Flickinger JC, Bissonette DJ, Bozik M, Lunsford LD. Survival benefit of stereotactic radiosurgery for patients with malignant glial neoplasms. Neurosurgery. 1997;41(4):776–83; discussion 83–5.

    Article  CAS  PubMed  Google Scholar 

  53. Shrieve DC, Alexander 3rd E, Black PM, Wen PY, Fine HA, Kooy HM, et al. Treatment of patients with primary glioblastoma multiforme with standard postoperative radiotherapy and radiosurgical boost: prognostic factors and long-term outcome. J Neurosurg. 1999;90(1):72–7. Epub 1999/07/21.

    Article  CAS  PubMed  Google Scholar 

  54. Shaw E, Scott C, Souhami L, Dinapoli R, Kline R, Loeffler J, et al. Single dose radiosurgical treatment of recurrent previously irradiated primary brain tumors and brain metastases: final report of RTOG protocol 90–05. Int J Radiat Oncol Biol Phys. 2000;47(2):291–8.

    Article  CAS  PubMed  Google Scholar 

  55. Souhami L, Seiferheld W, Brachman D, Podgorsak EB, Werner-Wasik M, Lustig R, et al. Randomized comparison of stereotactic radiosurgery followed by conventional radiotherapy with carmustine to conventional radiotherapy with carmustine for patients with glioblastoma multiforme: report of Radiation Therapy Oncology Group 93–05 protocol. Int J Radiat Oncol Biol Phys. 2004;60(3):853–60.

    Article  PubMed  Google Scholar 

  56. Selch MT, Ciacci JD, De Salles AA, Goetsch S, Brekhus SD. Radiosurgery for primary malignant brain tumors. In: De Salles AAF, Goetsch SJ, editors. Stereotactic surgery and radiosurgery. Madison, Wisconsin: Medical Physics Pub; 1993. p. 335–52.

    Google Scholar 

  57. Masciopinto JE, Levin AB, Mehta MP, Rhode BS. Stereotactic radiosurgery for glioblastoma: a final report of 31 patients. J Neurosurg. 1995;82(4):530–5.

    Article  CAS  PubMed  Google Scholar 

  58. Gannett D, Stea B, Lulu B, Adair T, Verdi C, Hamilton A. Stereotactic radiosurgery as an adjunct to surgery and external beam radiotherapy in the treatment of patients with malignant gliomas. Int J Radiat Oncol Biol Phys. 1995;33(2):461–8. Epub 1995/09/30.

    Article  CAS  PubMed  Google Scholar 

  59. Buatti JM, Friedman WA, Bova FJ, Mendenhall WM. Linac radiosurgery for high-grade gliomas: the University of Florida experience. Int J Radiat Oncol Biol Phys. 1995;32(1):205–10.

    Article  CAS  PubMed  Google Scholar 

  60. Shenouda G, Souhami L, Podgorsak EB, Bahary JP, Villemure JG, Caron JL, et al. Radiosurgery and accelerated radiotherapy for patients with glioblastoma. Can J Neurol Sci. 1997;24(2):110–5.

    Article  CAS  PubMed  Google Scholar 

  61. Nwokedi EC, DiBiase SJ, Jabbour S, Herman J, Amin P, Chin LS. Gamma knife stereotactic radiosurgery for patients with glioblastoma multiforme. Neurosurgery. 2002;50(1):41–6; discussion 6–7; Epub 2002/02/15.

    PubMed  Google Scholar 

  62. Hsieh PC, Chandler JP, Bhangoo S, Panagiotopoulos K, Kalapurakal JA, Marymont MH, et al. Adjuvant gamma knife stereotactic radiosurgery at the time of tumor progression potentially improves survival for patients with glioblastoma multiforme. Neurosurgery. 2005;57(4):684–92; discussion 684–92. Epub 2005/10/22.

    Article  PubMed  Google Scholar 

  63. Biswas T, Okunieff P, Schell MC, Smudzin T, Pilcher WH, Bakos RS, et al. Stereotactic radiosurgery for glioblastoma: retrospective analysis. Radiat Oncol. 2009;4:11. Epub 2009/03/19.

    Article  PubMed Central  PubMed  Google Scholar 

  64. Villavicencio AT, Burneikiene S, Romanelli P, Fariselli L, McNeely L, Lipani JD, et al. Survival following stereotactic radiosurgery for newly diagnosed and recurrent glioblastoma multiforme: a multicenter experience. Neurosurg Rev. 2009;32(4): 417–24. Epub 2009/07/28.

    Article  PubMed  Google Scholar 

  65. Pouratian N, Crowley RW, Sherman JH, Jagannathan J, Sheehan JP. Gamma Knife radiosurgery after radiation therapy as an adjunctive treatment for glioblastoma. J Neurooncol. 2009;94(3):409–18. Epub 2009/03/31.

    Article  CAS  PubMed  Google Scholar 

  66. Einstein DB, Wessels B, Bangert B, Fu P, Nelson AD, Cohen M, et al. Phase II Trial of Radiosurgery to Magnetic Resonance Spectroscopy-Defined High-Risk Tumor Volumes in Patients with Glioblastoma Multiforme. Int J Radiat Oncol Biol Phys. 2012;84(3):668–74. Epub 2012/03/27.

    Article  PubMed Central  PubMed  Google Scholar 

  67. Irish WD, Macdonald DR, Cairncross JG. Measuring bias in uncontrolled brain tumor trials–to randomize or not to randomize? Can J Neurol Sci. 1997;24(4):307–12.

    Article  CAS  PubMed  Google Scholar 

  68. Sarkaria JN, Mehta MP, Loeffler JS, Buatti JM, Chappell RJ, Levin AB, et al. Radiosurgery in the initial management of malignant gliomas: survival comparison with the RTOG recursive partitioning analysis. Radiation Therapy Oncology Group. Int J Radiat Oncol Biol Phys. 1995;32(4):931–41.

    Article  CAS  PubMed  Google Scholar 

  69. Werner-Wasik M, Scott CB, Nelson DF, Gaspar LE, Murray KJ, Fischbach JA, et al. Final report of a phase I/II trial of hyperfractionated and accelerated hyperfractionated radiation therapy with carmustine for adults with supratentorial malignant gliomas. Radiation Therapy Oncology Group Study 83–02. Cancer. 1996; 77(8):1535–43.

    Article  CAS  PubMed  Google Scholar 

  70. Nelson DF, Diener-West M, Weinstein AS, Schoenfeld D, Nelson JS, Sause WT, et al. A randomized comparison of misonidazole sensitized radiotherapy plus BCNU and radiotherapy plus BCNU for treatment of malignant glioma after surgery: final report of an RTOG study. Int J Radiat Oncol Biol Phys. 1986;12(10): 1793–800.

    Article  CAS  PubMed  Google Scholar 

  71. Nelson DF, Diener-West M, Horton J, Chang CH, Schoenfeld D, Nelson JS. Combined modality approach to treatment of malignant gliomas–re-evaluation of RTOG 7401/ECOG 1374 with long-term follow-up: a joint study of the Radiation Therapy Oncology Group and the Eastern Cooperative Oncology Group. NCI Monogr. 1988;6:279–84.

    PubMed  Google Scholar 

  72. Spitzer WO, Dobson AJ, Hall J, Chesterman E, Levi J, Shepherd R, et al. Measuring the quality of life of cancer patients: a concise QL-index for use by physicians. J Chronic Dis. 1981;34(12):585–97.

    Article  CAS  PubMed  Google Scholar 

  73. Loeffler JS, Alexander 3rd E, Shea WM, Wen PY, Fine HA, Kooy HM, et al. Radiosurgery as part of the initial management of patients with malignant gliomas. J Clin Oncol. 1992;10(9): 1379–85.

    CAS  PubMed  Google Scholar 

  74. Selker RG, Shapiro WR, Burger P, Blackwood MS, Arena VC, Gilder JC, et al. The Brain Tumor Cooperative Group NIH Trial 87–01: a randomized comparison of surgery, external radiotherapy, and carmustine versus surgery, interstitial radiotherapy boost, external radiation therapy, and carmustine. Neurosurgery. 2002;51(2):343–55; discussion 55–7.

    PubMed  Google Scholar 

  75. Tsao MN, Mehta MP, Whelan TJ, Morris DE, Hayman JA, Flickinger JC, et al. The American Society for Therapeutic Radiology and Oncology (ASTRO) evidence-based review of the role of radiosurgery for malignant glioma. Int J Radiat Oncol Biol Phys. 2005;63(1):47–55. Epub 2005/08/23.

    Article  PubMed  Google Scholar 

  76. Nieder C, Grosu AL, Molls M. A comparison of treatment results for recurrent malignant gliomas. Cancer Treat Rev. 2000;26(6): 397–409.

    Article  CAS  PubMed  Google Scholar 

  77. Brem H, Piantadosi S, Burger PC, Walker M, Selker R, Vick NA, et al. Placebo-controlled trial of safety and efficacy of intraoperative controlled delivery by biodegradable polymers of chemotherapy for recurrent gliomas. The Polymer-brain Tumor Treatment Group. Lancet. 1995;345(8956):1008–12.

    Article  CAS  PubMed  Google Scholar 

  78. Osoba D, Brada M, Yung WK, Prados M. Health-related quality of life in patients treated with temozolomide versus procarbazine for recurrent glioblastoma multiforme. J Clin Oncol. 2000;18(7):1481–91.

    CAS  PubMed  Google Scholar 

  79. Yung WK, Albright RE, Olson J, Fredericks R, Fink K, Prados MD, et al. A phase II study of temozolomide vs. procarbazine in patients with glioblastoma multiforme at first relapse. Br J Cancer. 2000;83(5):588–93.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  80. Batchelor T, Mulholland P, Neyns B, Nabors LB, Campone M, Wick A, et al. A phase III randomized study comparing the efficacy of Cediranib as monotherapy, and in combination with lomustine, with lomustine alone in recurrent glioblastoma patients. J Clin Oncol. 2013;31(26):3212–8.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  81. Friedman HS, Prados MD, Wen PY, Mikkelsen T, Schiff D, Abrey LE, et al. Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma. J Clin Oncol. 2009;27(28):4733–40. Epub 2009/09/02.

    Article  CAS  PubMed  Google Scholar 

  82. Kunwar S, Chang S, Westphal M, Vogelbaum M, Sampson J, Barnett G, et al. Phase III randomized trial of CED of IL13-PE38QQR vs Gliadel wafers for recurrent glioblastoma. Neuro Oncol. 2010;12(8):871–81. Epub 2010/06/01.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  83. Stupp R, Wong ET, Kanner AA, Steinberg D, Engelhard H, Heidecke V, et al. NovoTTF-100A versus physician’s choice chemotherapy in recurrent glioblastoma: A randomised phase III trial of a novel treatment modality. Eur J Cancer. 2012;48(14):2192–202. Epub 2012/05/23.

    Article  PubMed  Google Scholar 

  84. Chamberlain MC, Barba D, Kormanik P, Shea WM. Stereotactic radiosurgery for recurrent gliomas. Cancer. 1994;74(4):1342–7.

    Article  CAS  PubMed  Google Scholar 

  85. Shrieve DC, Alexander 3rd E, Wen PY, Fine HA, Kooy HM, Black PM, et al. Comparison of stereotactic radiosurgery and brachytherapy in the treatment of recurrent glioblastoma multiforme. Neurosurgery. 1995;36(2):275–82; discussion 82–4.

    Article  CAS  PubMed  Google Scholar 

  86. Mahajan A, McCutcheon IE, Suki D, Chang EL, Hassenbusch SJ, Weinberg JS, et al. Case–control study of stereotactic radiosurgery for recurrent glioblastoma multiforme. J Neurosurg. 2005;103(2): 210–7. Epub 2005/09/24.

    Article  PubMed  Google Scholar 

  87. Patel M, Siddiqui F, Jin JY, Mikkelsen T, Rosenblum M, Movsas B, et al. Salvage reirradiation for recurrent glioblastoma with radiosurgery: radiographic response and improved survival. J Neurooncol. 2009;92(2):185–91. Epub 2008/12/11.

    Article  PubMed  Google Scholar 

  88. Cuneo KC, Vredenburgh JJ, Sampson JH, Reardon DA, Desjardins A, Peters KB, et al. Safety and efficacy of stereotactic radiosurgery and adjuvant bevacizumab in patients with recurrent malignant gliomas. Int J Radiat Oncol Biol Phys. 2012;82(5):2018–24. Epub 2011/04/15.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  89. Cho KH, Hall WA, Gerbi BJ, Higgins PD, McGuire WA, Clark HB. Single dose versus fractionated stereotactic radiotherapy for recurrent high-grade gliomas. Int J Radiat Oncol Biol Phys. 1999;45(5):1133–41.

    Article  CAS  PubMed  Google Scholar 

  90. Leksell L. The stereotaxic method and radiosurgery of the brain. Acta Chirurgica Scandinavia. 1951;102(4):316–9.

    CAS  Google Scholar 

  91. Souhami L, Olivier A, Podgorsak EB, Villemure JG, Pla M, Sadikot AF. Fractionated stereotactic radiation therapy for intracranial tumors. Cancer. 1991;68(10):2101–8.

    Article  CAS  PubMed  Google Scholar 

  92. Clark BG, Podgorsak EB, Souhami L, Olivier A, Sixel KE, Caron JL. A halo-ring technique for fractionated stereotactic radiotherapy. Br J Radiol. 1993;66(786):522–7.

    Article  CAS  PubMed  Google Scholar 

  93. Baumert BG, Brada M, Bernier J, Kortmann RD, Dehing-Oberije C, Collette L, et al. EORTC 22972–26991/MRC BR10 trial: fractionated stereotactic boost following conventional radiotherapy of high grade gliomas. Clinical and quality-assurance results of the stereotactic boost arm. Radiother Oncol. 2008;88(2):163–72. Epub 2008/05/06.

    Article  PubMed  Google Scholar 

  94. Cardinale RM, Broaddus WC, Benedict SH, Schmidt-Ullrich RK, Kavanagh BD. Accelerated radiotherapy using weekly stereotactic comformal boosts for glioblastoma multiforme. Int J Radiat Oncol Biol Phys. 2000;48(3 Suppl 1):257.

    Article  Google Scholar 

  95. Clark BG, Souhami L, Pla C, Al-Amro AS, Bahary JP, Villemure JG, et al. The integral biologically effective dose to predict brain stem toxicity of hypofractionated stereotactic radiotherapy. Int J Radiat Oncol Biol Phys. 1998;40(3):667–75.

    Article  CAS  PubMed  Google Scholar 

  96. Levin VA, Bidaut L, Hou P, Kumar AJ, Wefel JS, Bekele BN, et al. Randomized double-blind placebo-controlled trial of bevacizumab therapy for radiation necrosis of the central nervous system. Int J Radiat Oncol Biol Phys. 2011;79(5):1487–95. Epub 2010/04/20.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  97. Chan AA, Lau A, Pirzkall A, Chang SM, Verhey LJ, Larson D, et al. Proton magnetic resonance spectroscopy imaging in the evaluation of patients undergoing gamma knife surgery for Grade IV glioma. J Neurosurg. 2004;101(3):467–75.

    Article  PubMed  Google Scholar 

  98. Nieder C, Weidenmann S, Stark S, Grosu AL. Phase II trial of functional imaging-optimized stereotactic fractionated radiotherapy plus temozolomide for recurrent high-grade glioma. Journal of Clinical Oncology, 2004 ASCO Annual Meeting Proceedings (Post-Meeting Edition). 2004;22(14S):1552.

    Google Scholar 

  99. Lederman G, Arbit E, Odaimi M, Lombardi E, Wrzolek M, Wronski M. Fractionated stereotactic radiosurgery and concurrent taxol in recurrent glioblastoma multiforme: a preliminary report. Int J Radiat Oncol Biol Phys. 1998;40(3):661–6.

    Article  CAS  PubMed  Google Scholar 

  100. Kohshi K, Yamamoto H, Nakahara A, Katoh T, Takagi M. Fractionated stereotactic radiotherapy using gamma unit after hyperbaric oxygenation on recurrent high-grade gliomas. J Neurooncol. 2007;82(3):297–303. Epub 2006/11/23.

    Article  PubMed  Google Scholar 

  101. Grecula JC, Grever M, Gupta N, Goofman J, Barth R, Christoforidis G. Phase I trial of motexafin gadolinium (Gd-Tex) during G-knife boost for glioblastoma multiforme. Clin Cancer Res. 2001;7(S).

    Google Scholar 

  102. Cuneo KC, Cabrera AR, Sampson JH, Allen K, Duffy E, Vredenburgh JJ, et al. Bevacizumab and Radiosurgery for Recurrent Malignant Glioma: Toxicity Results from a Prospective Pilot Study. Int J Radiat Oncol Biol Phys. 2011;81(2):S185.

    Article  Google Scholar 

  103. Park KJ, Kano H, Iyer A, Liu X, Niranjan A, Flickinger JC, et al. Salvage gamma knife stereotactic radiosurgery followed by bevacizumab for recurrent glioblastoma multiforme: a case–control study. J Neurooncol. 2012;107(2):323–33. Epub 2011/11/08.

    Article  CAS  PubMed  Google Scholar 

  104. Tatter SB, Shaw EG, Rosenblum ML, Karvelis KC, Kleinberg L, Weingart J, et al. An inflatable balloon catheter and liquid 125I radiation source (GliaSite Radiation Therapy System) for treatment of recurrent malignant glioma: multicenter safety and feasibility trial. J Neurosurg. 2003;99(2):297–303.

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Radiation Oncology, CHUM—Notre Dame, 1560 Sherbrooke E, Montreal, QC, Canada, H2L 4M1

    David Roberge M.D.

  2. Division of Radiation Oncology, McGill University, 1650 Cedar Avenue, Montreal, QC, Canada, H3G 1A4

    Luis Souhami M.D., F.A.S.T.R.O.

Authors
  1. David Roberge M.D.
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  2. Luis Souhami M.D., F.A.S.T.R.O.
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Correspondence to David Roberge M.D. .

Editor information

Editors and Affiliations

  1. Department of Neurosurgery, SUNY Upstate Medical University, Syracuse, USA

    Lawrence S. Chin

  2. Dept. of Radiation Oncology, Univ. of Maryland School of Medicine, Baltimore, Maryland, USA

    William F. Regine

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Roberge, D., Souhami, L. (2015). Stereotactic Radiosurgery and Radiotherapy in the Management of High-Grade Gliomas. In: Chin, L., Regine, W. (eds) Principles and Practice of Stereotactic Radiosurgery. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8363-2_17

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  • DOI: https://doi.org/10.1007/978-1-4614-8363-2_17

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