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Evaluation and Treatment of Nonunions in the Osteoporotic Patient

  • Geriatric Orthopedics (EG Meinberg, Section Editor)
  • Published:
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Abstract

Nonunions in osteoporotic patients are rare, but the incidence of fragility fractures is increasing, and therefore they will increase over the years. History of the evolution of the nonunion as well as its treatment are of paramount importance in understanding its etiology. Evaluating patient comorbidities and habits as well as a complete physical exam, including soft tissue conditions, deformities and joint stiffness, will help to achieve treatment goals. During evaluation, the use of all x rays, full-length films and laboratory tests to rule out infection will help to plan the surgery and to have all the necessary elements for success. Treatment using the biological chamber and diamond concepts, including the signaling molecules or growth factors, osteoprogenitor cells, extracelluar matrix as scaffold and mechanical stability, are the key elements for success.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Who scientific group on the assessment of osteoporosis at primary health care level. Summary Meeting Report Brussels, Belgium, 5-7 May, World Health Organization, 2004.

  2. Cauley J. Public Health Impact of Osteoporosis. J Gerontol A Biol Sci Med Sci. 2013;68(10):1243–51.

    Article  PubMed  Google Scholar 

  3. Giannoudis P, Zioupis T, Almalki T, Buckley R. Fracture healing in osteoporotic fractures: Is it really different? A basic science perspective. Injury. 2007;38S1:S90–9.

    Article  Google Scholar 

  4. Hobby B, Lee M. Managing Atrophic Nonunion in the Geriatric Population: Incidence, Distribution, and Causes. Orthop Clin N Am. 2013;44:251–6. This is an excellent review of the causes and its possible treatment options.

    Article  Google Scholar 

  5. Parker MJ, Raghavan R, Gurusamy K. Incidence of fracture-healing complications after femoral neck fractures. Clin Orthop Relat Res. 2007;458:175–9.

    PubMed  Google Scholar 

  6. Clement ND, Beauchamp NJ, Duckworth AD, McQueen MM, Court-Brown CM. The outcome of tibial diaphyseal fractures in the elderly. Bone Joint J. 2013;95-B(9):1255–62.

    Article  PubMed  CAS  Google Scholar 

  7. Antonova E, Le TK, Burge R, Mershon J. Tibial shaft fractures: costly burden of nonunions. BMC Musculoskeletal Disord. 2013;14:42. This article shows the impact of nonunions of the tibial shaft on consuming healthcare resources.

    Article  Google Scholar 

  8. Brinker MR, Hanus BD, Sen M, O’Connor DP. The devastating effects of tibial nonunion on health-related quality of life. J Bone Joint Surg Am. 2013;95(24):2170–6. This article. This article highlights the impact of nonunion in the lower extremity on the quality of life of patients.

    Article  PubMed  Google Scholar 

  9. Brinker MR, O’Connor DP, et al. Nonunions: evaluation and treatment (615-708). In: Browner BD, editor. Skeletal trauma: Basic Science, Management and reconstruction. Saunders: Philadelphia; 2009.

    Google Scholar 

  10. Heetveld MJ, Raaymakers EL, van Eck-Smit BL, et al. Internal fixation for displaced fractures of the femoral neck. Does bone density affect clinical outcome? J Bone Joint Surg (Br). 2005;87(3):367–73.

    Article  CAS  Google Scholar 

  11. Van Wunnik BP, Weijers PH, van Helden SH, et al. Osteoporosis is not a risk factor for the development of nonunion: a cohort nested case-control study. Injury. 2011;42(12):1491–4. This article shows that osteoporosis per se may not be a risk factor for nonunion.

    Article  PubMed  Google Scholar 

  12. Yang JJ, Lin LC, Chao KH, Chuang SY, Wu CC, Yeh TT, et al. Risk factors for nonunion in patients with intracapsular femoral neck fractures treated with three cannulated screws placed in either a triangle or an inverted triangle configuration. J Bone Joint Surg Am. 2013;95(1):61–9.

    Article  PubMed  Google Scholar 

  13. Hernandez RK, Do TP, Critchlow CW, Dent RE, Jick SS. Patient-related risk factors for fracture-healing complications in the United Kingdom General Practice Research Database. Acta Orthop. 2012;83(6):653–60.

    Article  PubMed Central  PubMed  Google Scholar 

  14. Lynch JR, Taitsman LA, Barei DP, Nork SE. Femoral nonunion: risk factors and treatment options. J Am Acad Orthop Surg. 2008;16(2):88–97.

    PubMed  Google Scholar 

  15. Bhattacharyya T, Bouchard KA, Phadke A, Meigs JB, Kassarjian A, Salamipour H. The accuracy of computed tomography for the diagnosis of tibial nonunion. J Bone Joint Surg Am. 2006;88(4):692–7.

    Article  PubMed  Google Scholar 

  16. Stucken C, Olszewski DC, Creevy WR, Murakami AM, Tornetta P. Preoperative diagnosis of infection in patients with nonunions. J Bone Joint Surg Am. 2013;95(15):1409–12.

    Article  PubMed  Google Scholar 

  17. Weber BG, Cech O. Pseudarthrosis. Hans Huber: Bern; 1976.

    Google Scholar 

  18. Giannoudis PV, Einhorn TA, Marsh D. Fracture healing: The diamond concept. Injury. 2007;38(4):S3–6. This article describes the diamond concept and its use in treating nonunions.

    Article  Google Scholar 

  19. Calori GM, Giannoudis PV. Enhancement of fracture healing with the diamond concept: the role of the biological chamber. Injury. 2011;42(11):1191–3. This article describes the concept of biological chamber and has some interesting questions for the future.

    Article  PubMed  Google Scholar 

  20. Bogunovic L, Cherney SM, Rothermich MA, Gardner MJ. Biomechanical Considerations for Surgical Stabilization of Osteoporotic Fractures. Orthop Clin North Am. 2013;44(2):183–200. An excellent review of the principles of fixing bones with osteoporosis.

    Article  PubMed  Google Scholar 

  21. Bottlang M, Doornink J, Lujan TJ, et al. Effects of construct stiffness on healing of fractures stabilized with locking plates. J Bone Joint Surg Am. 2010;92 Suppl 2:12–22.

    Article  PubMed Central  PubMed  Google Scholar 

  22. Doornink J, Fitzpatrick DC, Boldhaus S, et al. Effects of hybrid plating with locked and nonlocked screws on the strength of locked plating constructs in the osteoporotic diaphysis. J Trauma. 2010;69:411–7.

    Article  PubMed  Google Scholar 

  23. Höntzsch D, Blauth M, Attal R. Angle-stable fixation of intramedullary nails using the Angular Stable Locking System® (ASLS). Oper Orthop Traumatol. 2011;23(5):387–96.

    Article  PubMed  Google Scholar 

  24. Wähnert D, Stolarczyk Y, Hoffmeier KL, Raschke MJ, Hofmann GO, Mückley T. Long-term stability of angle-stable versus conventional locked intramedullary nails in distal tibia fractures. BMC Musculoskelet Disord. 2013;14:66.

    Article  PubMed Central  PubMed  Google Scholar 

  25. Wähnert D, Stolarczyk Y, Hoffmeier KL, Raschke MJ, Hofmann GO, Mückley T. The primary stability of angle-stable versus conventional locked intramedullary nails. Int Orthop. 2012;36(5):1059–64.

    Article  PubMed Central  PubMed  Google Scholar 

  26. Blokhuis TJ, Calori GM, Schmidmaier G. Autograft versus BMPs for the treatment of non-unions: What is the evidence? Injury. 2013;44 Suppl 1:S40–2.

    Article  PubMed  Google Scholar 

  27. Al C. Why are MSCs therapeutic? New data: new insight. J Pathol. 2009;217(2):318–24.

    Article  Google Scholar 

  28. Wu CC. Modified retrograde-locked nailing for aseptic femoral supracondylar nonunion with severe osteoporosis in elderly patients. J Trauma. 2011;71(2):E26–30.

    Article  PubMed  Google Scholar 

  29. Bae JH, Oh JK, Chon CS, et al. The biomechanical performance of locking plate fixation with intramedullary fibular strut graft augmentation in the treatment of unstable fractures of the proximal humerus. J Bone Joint Surg (Br). 2011;93(7):937–41.

    Article  Google Scholar 

  30. Gardner MJ, Boraiah S, Helfet DL, et al. Indirect medial reduction and strut support of proximal humerus fractures using an endosteal implant. J Orthop Trauma. 2008;22(3):195–200.

    Article  PubMed  Google Scholar 

  31. Vidyadhara S, Vamsi K, Rao SK, et al. Use of intramedullary fibular strut graft: a novel adjunct to plating in the treatment of osteoporotic humeral shaft nonunion. Int Orthop. 2009;33(4):1009–14.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  32. Gradl G, Knobe M, Stoffel M, et al. Biomechanical evaluation of locking plate fixation of proximal humeral fractures augmented with calcium phosphate cement. J Orthop Trauma. 2013;27(7):399–404.

    Article  PubMed  Google Scholar 

  33. Goldhahn J, Féron JM, Kanis J, Papapoulos S, Reginster JY, Rizzoli R, et al. Implications for Fracture Healing of Current and New Osteoporosis Treatments: An ESCEO Consensus Paper. Calcif Tissue Int. 2012;90(5):343–53. A review of the current drugs used in the osteoporosis treatment and their effects on fracture healing.

    Article  PubMed  CAS  Google Scholar 

  34. Alegre DN, Ribeiro C, Sousa C, et al. Possible benefits of strontium ranelate in complicated long bone fractures. Rheumatol Int. 2012;32:439–43.

    Article  PubMed  Google Scholar 

  35. Tarantino U, Celi M, Saturnino L, et al. Strontium ranelate and bone healing: report of two cases. Clin Cases Miner Bone Metab. 2010;7:65–8.

    PubMed Central  PubMed  Google Scholar 

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Conflict of Interest

Rodrigo F. Pesántez has received payment for lectures, including service on speakers bureaus from the AO Foundation.

Carlos Mario Olarte has received payment for lectures, including service on speakers bureaus from the AO Foundation.

Julián Salavarrieta declares that he has no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Correspondence to Rodrigo F. Pesántez.

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Pesántez, R.F., Olarte, C.M. & Salavarrieta, J. Evaluation and Treatment of Nonunions in the Osteoporotic Patient. Curr Geri Rep 3, 128–134 (2014). https://doi.org/10.1007/s13670-014-0083-8

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  • DOI: https://doi.org/10.1007/s13670-014-0083-8

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