Skip to main content

Advertisement

SpringerLink
Log in

Uncommon case of chronic myeloid leukemia with multiple myeloma

  • Case Report
  • Published:
International Journal of Hematology Aims and scope Submit manuscript

Abstract

We describe a 72-year-old woman who was diagnosed with asymptomatic multiple myeloma (MM) while being treated for Philadelphia (Ph)-positive chronic myeloid leukemia (CML) with imatinib mesylate (400 mg/day). The diagnosis of CML was based on the presence of the Ph chromosome and chimeric BCR-ABL messenger RNA. Three months after starting imatinib mesylate treatment, the patient achieved a complete cytogenetic response. However, bone marrow analysis at that time demonstrated plasmacytosis, and paraprotein (IgG, κ-type) was also detected. Hypercalcemia, renal failure, anemia, and bone lesions were not observed, which suggested that asymptomatic MM had developed. The coexistence of CML and MM is an extremely uncommon event that has only been reported in 12 cases. We discuss the relationship between CML and MM.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Wakayama T, Fujita S, Ago H. An elder patient coexisted with multiple myeloma and chronic myeloid leukemia before treatments. Med J Shimane Pref Cent Hosp. 2005;29:63–7.

    Google Scholar 

  2. Schwarzmeier JD, Shehata M, Ackermann J, Hilgarth M, Kaufmann H, Drach J. Simultaneous occurrence of chronic myeloid leukemia and multiple myeloma: evaluation by FISH analysis and in vitro expansion of bone marrow cells. Leukemia. 2003;17:1426–8.

    Article  CAS  PubMed  Google Scholar 

  3. Tanaka M, Kimura R, Matsutani A, Zaitsu K, Oka Y, Oizumi K. Coexistence of chronic myelogenous leukemia and multiple myeloma. Case report and review of the literature. Acta Haematol. 1998;99:221–3.

    Article  CAS  PubMed  Google Scholar 

  4. Boots MA, Pegrum GD. Simultaneous presentation of chronic granulocytic leukaemia and multiple myeloma. J Clin Pathol. 1982;35:364–5.

    Article  CAS  PubMed  Google Scholar 

  5. Galanopoulos A, Papadhimitriou SI, Kritikou-Griva E, Georgiakaki M, Anagnostopoulos NI. Multiple myeloma developing after imatinib mesylate therapy for chronic myeloid leukemia. Ann Hematol. 2009;88:281–2.

    Article  CAS  PubMed  Google Scholar 

  6. Garipidou V, Vakalopoulou S, Tziomalos K. Development of multiple myeloma in a patient with chronic myeloid leukemia after treatment with imatinib mesylate. Oncologist. 2005;10:457–8.

    Article  PubMed  Google Scholar 

  7. Yokota A, Onoda M, Uehara T, Terano T. Coexistence of chronic myelogenous leukemia and multiple myeloma. Rinsho Ketsueki. 2005;46:919.

    Google Scholar 

  8. Derghazarian C, Whittemore NB. Multiple myeloma superimposed on chronic myelocytic leukemia. Can Med Assoc J. 1974;110:1047–50.

    CAS  PubMed  Google Scholar 

  9. Nakagawa M, Noto S, Kobayashi H, Hayashi M. A case of a 47-year-old man who developed chronic myelogenous leukemia after therapy for multiple myeloma. J Obihiro Kosei Gen Hosp. 2003;6:101–6.

    Google Scholar 

  10. Nitta M, Tsuboi K, Yamashita S, Kato M, Hayami Y, Harada S, et al. Multiple myeloma preceding the development of chronic myelogenous leukemia. Int J Hematol. 1999;69:170–3.

    CAS  PubMed  Google Scholar 

  11. Klenn PJ, Hyun BH, Lee YH, Zheng WY. Multiple myeloma and chronic myelogenous leukemia-a case report with literature review. Yonsei Med J. 1993;34:293–300.

    CAS  PubMed  Google Scholar 

  12. MacSween JM, Langley GR. Light-chain disease (hypogammaglobulinemia and Bence Jones proteinuria) and sideroblastic anemia-preleukemic chronic granulocytic leukemia. Can Med Assoc J. 1972;106:995–8.

    CAS  PubMed  Google Scholar 

  13. International Myeloma Working Group. Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group. Br J Haematol. 2003;121:749–57.

    Article  Google Scholar 

  14. Standen GR, Jasani B, Wagstaff M, Wardrop CA. Chronic neutrophilic leukemia and multiple myeloma. An association with lambda light chain expression. Cancer. 1990;66:162–6.

    Article  CAS  PubMed  Google Scholar 

  15. Lewis MJ, Oelbaum MH, Coleman M, Allen S. An association between chronic neutrophilic leukaemia and multiple myeloma with a study of cobalamin-binding proteins. Br J Haematol. 1986;63:173–80.

    Article  CAS  PubMed  Google Scholar 

  16. Naparstek Y, Zlotnick A, Polliack A. Coexistent chronic myeloid leukemia and IgA monoclonal gammopathy: report of a case and review of the literature. Am J Med Sci. 1980;279:111–5.

    Article  CAS  PubMed  Google Scholar 

  17. Vorobiof DA, Benjamin J, Kaplan H, Dvilansky A. Chronic granulocytic leukemia, neutrophilic type, with paraproteinemia (IgA type K). Acta Haematol. 1978;60:316–20.

    Article  CAS  PubMed  Google Scholar 

  18. Shoenfeld Y, Berliner S, Ayalone A, Shaklai M, Djaldetti M, Pick AI, et al. Monoclonal gammopathy in patients with chronic and acute myeloid leukemia. Cancer. 1984;54:280–3.

    Article  CAS  PubMed  Google Scholar 

  19. Ritzmann SE, Stoufflet EJ, Houston EW, Levin WC. Coexistent chronic myelocytic leukemia, monoclonal gammopathy and multiple chromosomal abnormalities. Am J Med. 1966;41:981–9.

    Article  CAS  PubMed  Google Scholar 

  20. Maeda K, Abraham J. Polycythemia associated with myeloma. Am J Clin Pathol. 1984;82:501–5.

    CAS  PubMed  Google Scholar 

  21. Heinle EW Jr, Sarasti HO, Garcia D, Kenny JJ, Westerman MP. Polycythemia vera associated with lymphomatous diseases and myeloma. Arch Intern Med. 1966;118:351–5.

    Article  PubMed  Google Scholar 

  22. Brody JI, Beizer LH, Schwartz S. Multiple myeloma and the myeloproliferative syndromes. Am J Med. 1964;36:315–9.

    Article  CAS  PubMed  Google Scholar 

  23. Cobo F, Cervantes F, Martinez C, Salgado C, Blade J, Montserrat E, et al. Multiple myeloma following essential thrombocythemia. Leuk Lymphoma. 1995;20:177–9.

    Article  CAS  PubMed  Google Scholar 

  24. Selroos O, van Assendelft A. Thrombocythaemia and multiple myeloma. A report on two cases. Acta Med Scand. 1977;201:243–7.

    CAS  PubMed  Google Scholar 

  25. Kasimis BS, Yen-Lin R, Neiman RS. Multiple myeloma associated with myelofibrosis. Report of a case and literature review. Oncology. 1981;38:369–72.

    Article  CAS  PubMed  Google Scholar 

  26. Tzilves D, Gatopoulou A, Zervas K, Katodritou E, Patakiouta F, Tarpagos A, et al. Development of multiple myeloma in a patient with gastrointestinal stromal tumor treated with imatinib mesylate: a case report. World J Gastroenterol. 2007;13:2011–3.

    CAS  PubMed  Google Scholar 

  27. Pandiella A, Carvajal-Vergara X, Tabera S, Mateo G, Gutiérrez N, San Miguel JF. Imatinib mesylate (STI571) inhibits multiple myeloma cell proliferation and potentiates the effect of common antimyeloma agents. Br J Haematol. 2003;123:858–68.

    Article  CAS  PubMed  Google Scholar 

  28. Dispenzieri A, Gertz MA, Lacy MQ, Geyer SM, Greipp PR, Rajkumar SV, et al. A phase II trial of imatinib in patients with refractory/relapsed myeloma. Leuk Lymphoma. 2006;47:39–42.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Hematology, Saga Prefectural Hospital Koseikan, Saga, Japan

    Masaru Ide, Nobuo Kuwahara, Eijo Matsuishi & Hisashi Gondo

  2. Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga, 849-8501, Japan

    Masaru Ide & Shinya Kimura

Authors
  1. Masaru Ide
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Nobuo Kuwahara
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Eijo Matsuishi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Shinya Kimura
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hisashi Gondo
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Masaru Ide.

About this article

Cite this article

Ide, M., Kuwahara, N., Matsuishi, E. et al. Uncommon case of chronic myeloid leukemia with multiple myeloma. Int J Hematol 91, 699–704 (2010). https://doi.org/10.1007/s12185-010-0546-4

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12185-010-0546-4

Keywords

Search

Navigation