Abstract
Purpose
This study aimed to investigate the incidence, and underlying associations, of myocardial necrosis occurring in infants undergoing autopsy.
Methods
An autopsy database containing anonymized details of all infant autopsies conducted at Great Ormond Street Hospital between January 1996 and December 2010 was searched to identify all infants with myocardial necrosis. The characteristics of the necrosis and any underlying associations were reviewed.
Results
Myocardial necrosis was recorded in 187 autopsies out of a total of 1,637 (11.4 %), and was localized to the papillary muscles, subendocardial region, or trabeculae in 50.8 % of cases. The most common associations were congenital heart disease, perinatal asphyxia, coronary artery abnormalities, or sepsis. Three cases of apparently idiopathic myocardial infarction were identified and are described in detail.
Conclusions
Myocardial necrosis is relatively common in infants who die and undergo autopsy, and is most commonly associated with congenital heart disease and perinatal asphyxia. Myocardial infarction can occur in infancy in the absence of any apparent underlying cause: the etiology of these cases is unclear.
Similar content being viewed by others
References
Franciosi RA, Blanc WA. Myocardial infarcts in infants and children. I. A necropsy study in congenital heart disease. J Pediatr. 1968;73:309–19.
Bor I. Myocardial infarction and ischaemic heart disease in infants and children. Analysis of 29 cases and review of the literature. Arch Dis Child. 1969;44:268–81.
De Lucia V, Andreassi MG, Sabatini L, et al. Myocardial infarction and arterial thrombosis in identical newborn twins with homozygosity for the PAI-1 4 G/5 G polymorphism. Int J Cardiol. 2009;137:e1–4.
Clark AB, Stokes TA, Krous HF, et al. Myocardial infarction in a newborn heterozygous for the MTHFR C677T mutation. Pediatr Dev Pathol. 2012;15:232–6.
Donnelly WH, Bucciarelli RL, Nelson RM. Ischemic papillary muscle necrosis in stressed newborn infants. J Pediatr. 1980;96:295–300.
Barberi I, Calabrò MP, Cordaro S, et al. Myocardial ischemia in neonates with perinatal asphyxia. Electrocardiographic, echocardiographic and enzymatic correlations. Eur J Pediatr. 1999;158:742–7.
Murugan SJ, Gnanapragasam J, Vettukattil J. Acute myocardial infarction in the neonatal period. Cardiol Young. 2002;12:411–3.
De Vetten L, Bergman KA, Elzenga NJ, et al. Neonatal myocardial infarction or myocarditis? Pediatr Cardiol. 2011;32:492–7.
Richart R, Benirschke K. Myocardial infarction in the perinatal period: report of two cases in newborn infants. J Pediatr. 1959;55:706–12.
Brown NJ. Proceedings: myocardial infarction in the newborn. Arch Dis Child. 1974;49:1974–6.
Iannone LA, Duritz G, McCarty RJ. Myocardial infarction in the newborn: a case report complicated by cardiogenic shock and associated with normal coronary arteries. Am Heart J. 1975;89:232–5.
Kilbride H, Way GL, Merenstein GB, et al. Myocardial infarction in the neonate with normal heart and coronary arteries. Am J Dis Child. 1980;134:759–62.
Cabrera A, Izquierdo MA, Bilbao FJ. Myocardial infarction with ventricular aneurysm in a newborn with normal coronary arteries. Int J Cardiol. 1991;31:243–5.
Berry CL. Myocardial ischemia in infancy and childhood. J Clin Pathol. 1967;20:38–41.
Setzer E, Ermocilla R, Tonkin I, et al. Papillary muscle necrosis in a neonatal autopsy population: incidence and associated clinical manifestations. J Pediatr. 1980;96:289–94.
European Association for Cardio-thoracic Surgery/Society of Thoracic Surgeons version of the International Paediatric and Congenital Cardiac Code: Diagnosis Short List 2012—Version 3.0. 2010. http://ipccc.net/Download%20the%20IPCCC/EACTS-STS/DownloadEACTS-STSTOC.htm. Accessed 14 March 2013.
Siebert JR. Perinatal, fetal and embryonic autopsy. In: Gilbert-Barness E, editor. Potter’s pathology of the fetus, infant and child. 2nd ed. Philadelphia, PA: Mosby Elsevier; 2007. p. 725.
Office for National Statistics Statistical Bulletin: Births and Deaths in England and Wales (Provisional), 2011. 2012. http://www.ons.gov.uk/ons/dcp171778_271535.pdf. Accessed 14 March 2013.
Acknowledgments
ARB is supported by a grant from the Lullaby Trust. NJS is part supported by GOSHCC and the NIHR GOSH BRC. This article presents independent research funded by the National Institute for Health Research (NIHR). The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Bamber, A.R., Pryce, J., Cook, A. et al. Myocardial necrosis and infarction in newborns and infants. Forensic Sci Med Pathol 9, 521–527 (2013). https://doi.org/10.1007/s12024-013-9472-0
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12024-013-9472-0