Skip to main content

Advertisement

SpringerLink
Log in

Chronic Fluoride Exposure Has a Role in Etiology of Coronary Artery Ectasia: Sialic Acid/Glycosaminoglycan Ratio

  • Published:
Biological Trace Element Research Aims and scope Submit manuscript

Abstract

The sialic acid/glycosaminoglycan ratio was determined in 35 coronary artery ectasia patients and 35 control subjects to determine the possible role of fluoride in the etiology of the disease. The coronary artery ectasia patients and controls were selected from subjects who underwent coronary angiography. The mean serum sialic acid level was significantly lower in patients with coronary artery ectasia (CAE) than in controls (340.3 ± 28.6 vs. 427.0 ± 15.9 μg/mL, respectively; p < 0.001). The mean serum glycosaminoglycan level was significantly higher in patients with CAE than in controls (5,013.1 ± 158.6 vs. 3,833.6 ± 237.1 μg/mL, respectively; p < 0.001). The sialic acid/glycosaminoglycan ratio in patients with coronary artery ectasia was significantly lower than in controls (0.068 ± 0.007 vs. 0.111 ± 0.005; p < 0.001). There was more than 38.7% reduction in this ratio in patients with CAE when compared with controls. We demonstrated that chronic fluoride exposure has an important role in pathogenesis of coronary artery ectasia.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Swaye PS, Fisher LD, Litwin P et al (1983) Aneurysmal coronary artery disease. Circulation 67:134–138

    Article  PubMed  CAS  Google Scholar 

  2. Hartnell GG, Parnell BM, Pridie RB (1985) Coronary artery ectasia, its prevalence and clinical significance in 4,993 patients. Br Heart J 54:392–395

    Article  PubMed  CAS  Google Scholar 

  3. Li JJ, Li Z, Li (2007) Is any link between inflammation and coronary artery ectasia? Med Hypotheses 69(3):678–683

    Article  PubMed  CAS  Google Scholar 

  4. Ozsvath DL (2009) Fluoride and environmental health: a review. Rev Environ Sci Biotechnol 8:59–79

    Article  CAS  Google Scholar 

  5. Oruc N (2008) Occurrence and problems of high fluoride waters in Turkey: an overview. Environ Geochem Health 30(4):315–323

    Article  PubMed  CAS  Google Scholar 

  6. Nazli C, Altinbas A, Kinay O et al (2001) The incidence of coronary artery ectasia in Isparta region in Turkey. Eur Heart J 22(Suppl):191

    Google Scholar 

  7. Sorrel VL, Davis MJ, Bove AA (1996) Origins of coronary artery ectasia. Lancet 347:136–137

    Article  Google Scholar 

  8. Çenesiz S, Özcan A (2005) Chronic effects of fluoride in tuj sheep on serum levels of total protein, albumin, uric acid, and nitric oxide and activities of lactate dehydrogenase and leucine aminopeptidase. Fluoride 38:52–56

    Google Scholar 

  9. Sireli M, Bulbul A (2004) The effect of acute fluoride poisoning on nitric oxide and methemoglobin formation in the Guinea pig. Turk J Vet Anim Sci 28:591–595

    Google Scholar 

  10. Inkielewicz-Stepniak I, Czarnowski W (2010) Oxidative stress parameters in rats exposed to fluoride and caffeine. Food Chem Toxicol 48(6):1607–1611

    Article  PubMed  CAS  Google Scholar 

  11. Liu G, Chai C, Cui L (2003) Fluoride causing abnormally elevated serum nitric oxide levels in chicks. Environ Toxicol Pharmacol 13:199–204

    Article  PubMed  CAS  Google Scholar 

  12. Hassan HA, Yousef MI (2009) Mitigating effects of antioxidant properties of black berry juice on sodium fluoride induced-hepatotoxicity and oxidative stress in rats. Food Chem Toxicol 47(9):2332–2337

    Article  PubMed  CAS  Google Scholar 

  13. Zhan XA, Xu ZR, Li JX et al (2005) Effects of fluorosis on lipid peroxidation and antioxidant systems in young pigs. Fluoride 38:157–161

    CAS  Google Scholar 

  14. Jha M, Susheela AK, Krishna N et al (1982) Excessive ingestion of fluoride and the significance of sialic acid: glycosaminoglycans in the serum of rabbit and human subjects. J Toxicol Clin Toxicol 19(10):1023–1030

    Article  PubMed  CAS  Google Scholar 

  15. Falsetti HL, Carroll RJ (1976) Coronary artery aneurysm. Chest 69:630–636

    Article  PubMed  CAS  Google Scholar 

  16. Warren L (1959) The thiobarbituric acid assay of sialic acids. J Biol Chem 234:1971–1975

    PubMed  CAS  Google Scholar 

  17. Whiteman P (1973) The quantitative measurement of alcian blue-GAG complexes. Biochem J 131:343–350

    PubMed  CAS  Google Scholar 

  18. Varol E, Akcay S, Ersoy IH et al (2010) Aortic elasticity is impaired in patients with endemic fluorosis. Biol Trace Elem Res 133(2):121–127

    Article  PubMed  CAS  Google Scholar 

  19. Schauer R, Kelm S, Reuter G et al (1995) Biochemistry and role of sialic acids. In: Rosenberg A (ed) Biology of the sialic acids. Plenum, New York

    Google Scholar 

  20. Serdar Z, Yesilbursa D, Dirican M et al (2007) Sialic acid and oxidizability of lipid and proteins and antioxidant status in patients with coronary artery disease. Cell Biochem Funct 25:655–664

    Article  PubMed  CAS  Google Scholar 

  21. Sharma YD (1983) Serum sialic acid and ceruloplasmin levels in experimental fluorosis. Toxicol Lett 15:l–5

    Google Scholar 

  22. Ciftci G, Cenesiz S, Yarim GF et al (2010) Effect of fluoride exposure on serum glycoprotein pattern and sialic acid level in rabbits. Biol Trace Elem Res 133(1):51–59

    Article  PubMed  CAS  Google Scholar 

  23. Varol E, Akcay S, Ersoy IH et al (2010) Impact of chronic fluorosis on left ventricular diastolic and global functions. Sci Total Environ 408(11):2295–2298

    Article  PubMed  CAS  Google Scholar 

  24. Barbier O, Arreola-Mendoza L, Del Razo LM (2010) Molecular mechanisms of fluoride toxicity. Chem Biol Interact 188(2):319–333

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Alanya State Hospital, Antalya, Turkey

    Ozkan Dede

  2. Department of Cardiology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey

    Ercan Varol & Ahmet Altinbas

  3. Department of Geology, Faculty of Engineering, Suleyman Demirel University, Isparta, Turkey

    Simge Varol

Authors
  1. Ozkan Dede
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ercan Varol
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ahmet Altinbas
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Simge Varol
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ercan Varol.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dede, O., Varol, E., Altinbas, A. et al. Chronic Fluoride Exposure Has a Role in Etiology of Coronary Artery Ectasia: Sialic Acid/Glycosaminoglycan Ratio. Biol Trace Elem Res 143, 695–701 (2011). https://doi.org/10.1007/s12011-010-8913-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12011-010-8913-9

Keywords

Search

Navigation