Abstract
Chronic myelogenous leukemia (CML) is a clonal hematopoietic stem-cell disorder characterized by the (9:22) translocation and resultant production of the constitutively activated bcr-abl tyrosine kinase. Characterized clinically by marked myeloid proliferation, it invariably terminates in an acute leukemia. Conventional therapeutic options include interferon-based regimens and stem-cell transplantation, with stem-cell transplantation being the only curative therapy. Through rational drug development, STI571, a bcr-abl tyrosine kinase inhibitor, has emerged as a paradigm for gene product-targeted therapy, offering new hope for expanded treatment options for patients with CML.
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Mauro, M.J., Druker, B.J. STI571: A gene product-targeted therapy for leukemia. Curr Oncol Rep 3, 223–227 (2001). https://doi.org/10.1007/s11912-001-0054-z
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DOI: https://doi.org/10.1007/s11912-001-0054-z