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Effects of Weight Loss on Lipid Transfer Proteins in Morbidly Obese Women

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Lipids

Abstract

Obesity is associated with lipid abnormalities leading to an increased morbidity and mortality from atherosclerotic disease. Lipid transfer proteins such as Cholesteryl Ester Transfer Protein (CETP) and Phospholipid Transfer Protein (PLTP), and lipases such as lipoprotein lipase (LPL) and hepatic lipase (HL) are involved in the pathogenesis of the obesity associated proatherogenic dyslipidemia. Nineteen severely obese female subjects undergoing laparosopic gastric banding participated in this prospective study. Subjects were examined with respect to body composition, lipid profile, CETP, PLTP, LPL and HL before and 1 year after surgical treatment. Mean weight loss was 22.2 kg, mainly due to losses in the fat depots. Triglycerides decreased and HDL2-C increased significantly. In respect to transfer proteins mean CETP mass decreased from 1.82 to 1.71 μg mL−1 (P = 0.043) and mean PLTP activity was reduced from 7.15 to 6.12 μmol mL−1 h−1 (P = 0.002), in parallel. In addition, both mean LPL activity and mean HL activity tended to decrease from 297 to 248 nmol mL−1 h−1 for LPL (P = 0.139) and from 371 to 319 nmol mL−1 h−1 for HL (P = 0.170), respectively. We conclude that weight loss induced by bariatric surgery is associated with the amelioration of the obesity-associated dyslipidemic state. This improvement may be attributable to decreased mass and action of the adipocyte tissue derived lipid transfer proteins CETP and PLTP.

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Abbreviations

CE:

Cholesteryl esters

CETP:

Cholesteryl ester transfer protein

HDL:

High density lipoprotein

HL:

Hepatic lipase

LAGB:

Laparoscopic adjustable gastric banding

LDL:

Low density lipoprotein

LPL:

Lipoprotein lipase

PLTP:

Phospholipid transfer protein

VLDL:

Very low-density lipoprotein

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Acknowledgments

The expert technical assistance of Ursula Stanzl and Karin Salzmann is gratefully acknowledged.

Author information

Authors and Affiliations

  1. Department of Internal Medicine I, Medical University Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria

    Markus W. Laimer, Julia Engl, Alexander Tschoner, Susanne Kaser, Andreas Ritsch, Tobias Tatarczyk, Josef R. Patsch & Christoph F. Ebenbichler

  2. Department of Pediatrics, Medical University Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria

    Markus Rauchenzauner

  3. Department of General Surgery, SJOG Hospital Salzburg, Kajetanerplatz 1, 5010, Salzburg, Austria

    Helmut Weiss

  4. Department of General, Thoracic and Transplant Surgery, Medical University Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria

    Franz Aigner

Authors
  1. Markus W. Laimer
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  2. Julia Engl
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  3. Alexander Tschoner
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  4. Susanne Kaser
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  5. Andreas Ritsch
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  6. Tobias Tatarczyk
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  7. Markus Rauchenzauner
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  8. Helmut Weiss
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  9. Franz Aigner
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  10. Josef R. Patsch
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  11. Christoph F. Ebenbichler
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Corresponding author

Correspondence to Christoph F. Ebenbichler.

Additional information

M. W. Laimer and J. Engl contributed equally.

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Laimer, M.W., Engl, J., Tschoner, A. et al. Effects of Weight Loss on Lipid Transfer Proteins in Morbidly Obese Women. Lipids 44, 1125–1130 (2009). https://doi.org/10.1007/s11745-009-3349-8

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  • DOI: https://doi.org/10.1007/s11745-009-3349-8

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