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Biocompatibility Study of Zirconium-Based Bulk Metallic Glasses for Orthopedic Applications

  • Symposium: Bulk Metallic Glasses VI
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Abstract

Bulk metallic glasses (BMGs) represent an emerging class of materials that offer an attractive combination of properties, such as high strength, low modulus, good fatigue limit, and near-net-shape formability. The BMGs have been explored in mechanical, chemical, and magnetic applications. However, little research has been attracted in the biomedical field. In this work, we study the potential of BMGs for the orthopedic repair and replacement. We report the biocompatibility study of zirconium (Zr)–based solid BMGs using mouse osteoblast cells. Cell attachment, proliferation, and differentiation are compared to Ti-6Al-4V, a well-studied alloy biomaterial. Our in-vitro study has demonstrated that cells cultured on the Zr-based BMG substrate showed higher attachment, alkaline phosphatase activity, and bone matrix deposition compared to those grown on the control Ti alloy substrate. Cytotoxicity staining also revealed the remarkable viability of cells growing on the BMG substrates.

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References

  1. M. Navarro, A. Michiardi, O. Castano, and J.A. Planell: J. R. Soc. Interface, 2008, vol. 5, pp. 1137–58.

    Article  PubMed  CAS  Google Scholar 

  2. D.R. Sumner and J.O. Galante: Clin. Orthop. Relat. Res., 1992, vol. 274, pp. 202–12.

    PubMed  Google Scholar 

  3. M.L. Morrison, R.A. Buchanan, R.V. Leon, C.T. Liu, B.A. Green, P.K Liaw, and J.A. Horton: J. Biomed. Mater. Res., 2005, vol. 74A, pp. 430–38.

    Article  CAS  Google Scholar 

  4. C.A. Engh, J.D. Bobyn, and A.H. Glassman: J. Bone Joint Surg., 1987, vol. 69B, pp. 45–55.

    Google Scholar 

  5. C.J. Gilbert, R.O. Ritchie, and W.L. Johnson: Appl. Phys. Lett., 1997, vol. 71, pp. 476–78.

    Article  ADS  CAS  Google Scholar 

  6. J. Schroers and W.L. Johnson: Phys. Rev. Lett., 2004, vol. 93, p. 255506.

    Article  PubMed  ADS  CAS  Google Scholar 

  7. A. Inoue and N. Nishiyama: MRS Bull., 2007, vol. 32, pp. 651–58.

    CAS  Google Scholar 

  8. S. Buzzi, K. Jin, P.J. Uggowitzer, S. Tosatti, I. Gerber, and J.F. Löffler: Intermetallics, 2006, vol. 14, pp. 729–34.

    Article  CAS  Google Scholar 

  9. L. Liu, C.L. Qiu, Q. Chen, K.C. Chan, and S.M. Zhang: J. Biomed. Mater. Res., 2008, vol. 86A, pp. 160–69.

    Article  CAS  Google Scholar 

  10. K.C. Popat, M. Eltgroth, T.J. LaTempa, C.A. Grimes, and T.A. Desai: Biomaterials, 2007, vol. 28, pp. 4880–88.

    Article  PubMed  CAS  Google Scholar 

  11. Y.H. Liu, G. Wang, R.J. Wang, D.Q. Zhao, M.X. Pan, and W.H. Wang: Science, 2007, vol. 315, pp. 1385–88.

    Article  PubMed  ADS  CAS  Google Scholar 

  12. S. Hiromoto, A.P. Tsai, M. Sumita, and T. Hanawa: Mater. Trans., 2001, vol. 42, pp. 656–59.

    Article  CAS  Google Scholar 

  13. S. Hiromoto, K. Asami, A.P. Tsai, and T. Hanawa: Mater. Trans., 2002, vol. 43, pp. 261–66.

    Article  CAS  Google Scholar 

  14. D.G. Castner and B.D. Ratner: Surf. Sci., 2002, vol. 500, pp. 28–60.

    Article  ADS  CAS  Google Scholar 

  15. P.I. Branemark: J. Prosthet. Dent., 1983, vol. 50, pp. 399–410.

    Article  PubMed  CAS  Google Scholar 

  16. M.B. Guglielmotti, S. Renou, and R.L. Cabrini: Int. J. Oral Maxillofac. Implants, 1999, vol. 14, pp. 565–70.

    PubMed  CAS  Google Scholar 

  17. O.B. Kulakov, A.A. Doktorov, S.V. D’Iakova, I. Denisov-Nikol’skii lul, and K.A. Grotz: Morfologiia, 2005, vol. 127, pp. 52–55.

    PubMed  CAS  Google Scholar 

  18. R.L. Willaims, J.A. Hunt, and P. Tengvall: JBMR, 1995, vol. 29, pp. 1545–55.

    Google Scholar 

  19. C.M. Gundberg: Clin. Lab. Med., 2000, vol. 20, pp. 489–501.

    PubMed  CAS  Google Scholar 

  20. G.G. Bellows, J.E. Aubin, and J.N.M. Heersche: Bone Miner., 1991, vol. 14, pp. 27–40.

    Article  PubMed  CAS  Google Scholar 

  21. Y. Okazaki, S. Rao, Y. Ito, and T. Tateishi: Biomaterials, 1998, vol. 19, pp. 1197–1215.

    Article  PubMed  CAS  Google Scholar 

  22. M. Niinomi: Metall. Mater. Trans. A, 2002, vol. 33A, pp. 477–86.

    Article  ADS  Google Scholar 

  23. D.M. Brunette, P. Tengvall, M. Textor, and P. Thomsen: Titanium in Medicine: Material Science, Surface Science, Engineering, Biological Responses and Medical Applications, Springer, New York, NY, 2001, pp. 174–76.

  24. A.H. Brothers and D.C. Dunand: MRS Bull., 2007, vol. 32, pp. 639–43.

    CAS  Google Scholar 

  25. B.R. Barnard, P.K. Liaw, M.D. Demetriou, and W.L. Johnson: Corros. Sci., 2008, vol. 50, pp. 2135–39.

    Article  CAS  Google Scholar 

  26. M.D. Demetriou, C. Veazey, J.S. Harmon, J.P. Schramm, and W.L. Johnson: Phys. Rev. Lett., 2008, vol. 101, p. 145702.

    Article  PubMed  ADS  CAS  Google Scholar 

  27. E.D. Spoerke, N.G. Murray, H. Li, L.C. Brinson, D.C. Dunand, and S.I. Stupp: Acta Biomater., 2005, vol. 1, pp. 523–33.

    Article  PubMed  Google Scholar 

  28. T. Wada and A. Inoue: Mater. Trans., 2004, vol. 45, pp. 2761–65.

    Article  CAS  Google Scholar 

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Acknowledgments

We thank Dr. John Dunlap for his help with the cell fixation for SEM; Mr. Jack McPherson for helpful discussion; and Professor Jun Shen, Harbin Institute of Technology of China, for initial supply of BMG material. One of the authors (PKL) is very grateful for the support of the National Science Foundation Integrative Graduate Education and Research Traineeship (IGERT) Program (Grant No. DGE-9987548) and the International Materials Institute (IMI) Program (Grant No. DMR-0231320).

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Authors and Affiliations

  1. Department of Materials Science and Engineering, University of Tennessee, Knoxville, TN, 37996, USA

    Wei He (Assistant Professor), Andrew Chuang (Graduate Student), Zheng Cao (Graduate Student) & Peter K. Liaw (Professor)

  2. Department of Mechanical, Aerospace, and Biomedical Engineering, University of Tennessee, Knoxville, TN, 37996, USA

    Wei He (Assistant Professor)

Authors
  1. Wei He
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  2. Andrew Chuang
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  3. Zheng Cao
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  4. Peter K. Liaw
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Correspondence to Wei He.

Additional information

This article is based on a presentation given in the symposium “Bulk Metallic Glasses VI,” which occurred during the TMS Annual Meeting, February 15–19, 2009, in San Francisco, CA, under the auspices of TMS, the TMS Structural Materials Division, TMS/ASM: Mechanical Behavior of Materials Committee.

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He, W., Chuang, A., Cao, Z. et al. Biocompatibility Study of Zirconium-Based Bulk Metallic Glasses for Orthopedic Applications. Metall Mater Trans A 41, 1726–1734 (2010). https://doi.org/10.1007/s11661-009-0150-5

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