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Effects of Li addition on the corrosion behaviour and biocompatibility of Mg(Li)–Zn–Ca metallic glasses

  • Biomaterials
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Abstract

Magnesium alloys with suitable corrosion behaviour and good mechanical properties are desired for biodegradable materials. In the current study, novel Mg–Li-based metallic glasses (MGs) demonstrate potential clinical applications as implantable biodegradable materials. The amorphous structure of MGs provides suitable elastic modulus with human bone. The enhanced corrosion resistance of MGs realises a uniform corrosion process, as well as maintains a stable acid-based environment, and increases cell proliferation. A schematic model is proposed to illustrate the corrosion mechanisms of MGs. Adding Li significantly improves the corrosion resistance of MGs. Both the indirect cytotoxicity and direct cell culture assays are conducted using transfected osteoblasts (hFOB) cells. Results show that the novel Mg–Li–Zn–Ca MGs have good biocompatibility.

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Acknowledgements

This study was supported by National Natural Science Foundation, China (Grant Nos. 51771120 and 51304136), project supported by Shanghai Key Technology Support Program (Shanghai Science and Technology Ministry China. Grant No. 16060502400).

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Authors and Affiliations

  1. School of Materials Science and Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, China

    He Meifeng, Wang Hao, Zhou Kunguang, Pan Deng & Liu Fang

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  1. He Meifeng
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  2. Wang Hao
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  3. Zhou Kunguang
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  4. Pan Deng
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  5. Liu Fang
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Correspondence to Pan Deng or Liu Fang.

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Meifeng, H., Hao, W., Kunguang, Z. et al. Effects of Li addition on the corrosion behaviour and biocompatibility of Mg(Li)–Zn–Ca metallic glasses. J Mater Sci 53, 9928–9942 (2018). https://doi.org/10.1007/s10853-018-2323-3

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  • DOI: https://doi.org/10.1007/s10853-018-2323-3

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