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Terbinafine hydrochloride intercalated in montmorillonite: synthesis and characterization

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Abstract

The novel antifungal hybrid of terbinafine hydrochloride (TER-HCl)/montmorillonite was synthesized by the intercalation method under mechanical stirring. Intercalation of TER-HCl in the MMT galleries was characterized by X-ray diffraction (XRD), Fourier transform infrared spectra, elemental analysis (EA). and thermogravimetric analysis (TGA). The results from IR, TGA, and EA showed a difference in chemical composition of the MMT and the TER-HCl/MMT. XRD analysis showed that the basal spacing of montmorillonite significantly expanded from 1.53 to 2.79 nm. TER-HCl was successfully intercalated into the interlayer of MMT, and 28 % of TER-HCl was released after 48 h in 0.9 % (w/v) NaCl aqueous solution (pH 7) at 37 ± 0.5 °C. The antifungal activity of the hybrid against Candida albicans was evaluated using the inhibitory zone method and the minimum inhibitory concentration. The TER-HCl/MMT strongly inhibited C. albicans. These results show that TER-HCl/MMT can be useful in biomedical applications.

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Acknowledgements

This study was supported by The Research Foundation of Education Bureau of Jiangsu Province, China (JHB05-21); The Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD); Base of production, education & research of prospective joint research project of Jiangsu Province (BY2011109); The Nature Science Foundation of Jiangsu Higher Education Institutions of China (Grant No. 11KJB150007).

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Authors and Affiliations

  1. Jiangsu Engineering Research Center for Biomedical Function Materials, Nanjing Normal University, Nanjing, 210046, China

    Na Meng , Ning-Lin Zhou & Jian Shen

  2. Jiangsu Key Laboratory for Supramolecular Medicinal Materials and Applications, College of Life Science, Nanjing Normal University, Nanjing, 210046, China

    Na Meng

  3. Jiangsu Province Key Laboratory for Molecular and Medical Biotechnology, Life Sciences College, Nanjing Normal University, Nanjing, 210046, China

    Ning-Lin Zhou & Jian Shen

  4. Jiangsu Technological Research Center for Interfacial Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, China

    Ning-Lin Zhou & Jian Shen

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  1. Na Meng
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  2. Ning-Lin Zhou
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  3. Jian Shen
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Correspondence to Ning-Lin Zhou or Jian Shen.

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Meng , N., Zhou, NL. & Shen, J. Terbinafine hydrochloride intercalated in montmorillonite: synthesis and characterization. Res Chem Intermed 39, 671–680 (2013). https://doi.org/10.1007/s11164-012-0588-8

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  • DOI: https://doi.org/10.1007/s11164-012-0588-8

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