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Ferroelectric transducer arrays for transdermal insulin delivery

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Abstract

The goal of this research was the development of a portable therapeutic device for the treatment of diabetes. A 3×3 cymbal array has been successfully tested in noninvasive insulin delivery experiments. The cymbal is a composite flextensional transducer constructed from a poled PZT ceramic and shaped metal endcaps that amplify the transducer motions by two orders of magnitude. Nine cymbals are wired in parallel and potted in polyurethane to form the flat panel arrays. When driven near resonance (20 kHz), the array generated a low intensity acoustic beam of 100 mW/cm2. Animal experiments on hyperglycemic rats and rabbits demonstrated the ultrasonic enhancement of transdermal insulin delivery.

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Authors and Affiliations

  1. Department of Bioengineering, The Pennsylvania State University, University Park, PA, 16802, USA

    Benjamin Snyder, Seungjun Lee & Nadine Barrie Smith

  2. Material Research Laboratory, The Pennsylvania State University, University Park, PA, 16802, USA

    Benjamin Snyder, Nadine Barrie Smith & Robert E. Newnham

  3. Graduate Program in Acoustics, The Pennsylvania State University, University Park, PA, 16802, USA

    Nadine Barrie Smith

Authors
  1. Benjamin Snyder
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  2. Seungjun Lee
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  3. Nadine Barrie Smith
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  4. Robert E. Newnham
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Correspondence to Nadine Barrie Smith.

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Snyder, B., Lee, S., Smith, N.B. et al. Ferroelectric transducer arrays for transdermal insulin delivery. J Mater Sci 41, 211–216 (2006). https://doi.org/10.1007/s10853-006-6080-3

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  • DOI: https://doi.org/10.1007/s10853-006-6080-3

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