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Linguistic, psychometric validation and diagnostic ability assessment of an Italian version of a 19-item wearing-off questionnaire for wearing-off detection in Parkinson’s disease

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Abstract

A patient self-rated 19-item wearing-off questionnaire (WOQ-19) was shown to be a potent screening tool for wearing-off (WO) in patients with Parkinson’s disease. As part of the early detection of wearing-off in Parkinson’s disease study, we preliminarily performed a linguistic and a psychometric validation of an Italian version of the WOQ-19. Moreover, we assessed the sensitivity and specificity of the WOQ-19 in the office-based settings. The psychometric validation study included assessment of discriminant ability, internal consistency and test–retest reliability. The intraclass correlation coefficient (ICC) and the Cronbach’s Alpha were assessed. The WOQ-19 sensitivity and specificity were calculated in respect to the physician assessment of WO, taken as the gold standard. The Italian version of WOQ-19 was found easy to understand by ≥80% of the patients. The number of WO-related symptoms detected by WOQ-19 was 7.5 ± 3.2 in patients with WO and 1.6 ± 2.6 in patients without WO (p < 0.0001). Cronbach’s alpha was equal to 0.868 for the total number of WO symptoms. The ICC value was equal to 0.858 for WO-related symptoms as a whole. The diagnostic ability study recruited 207 patients: for a WOQ-19 cut-off ≥2, the sensitivity was equal to 0.881 and the specificity was 0.674. This is the first validation of WOQ-19 in Italian, with excellent linguistic validity and psychometric properties. WOQ-19 was confirmed to be reliable in WO detection.

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Acknowledgments

This study was supported by an educational grant issued by Novartis, Italy. The authors are grateful to Medidata for data collection and analysis and to Shalom Haggiag for helping writing the manuscript.

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Authors and Affiliations

  1. Department of Neurosciences, University of Genoa, Genoa, Italy

    Giovanni Abbruzzese & Tiziano Tamburini

  2. Department for Parkinson’s Disease, IRCCS San Camillo, Venice, Italy

    Angelo Antonini & Laura Bernardi

  3. Scuola Medica Salernitana, Università degli Studi di Salerno, Salerno, Italy

    Paolo Barone

  4. Department of Neurology, Institute of Research and Medical Care, IRCCS San Raffaele, Rome, Italy

    Fabrizio Stocchi & Laura Vacca

  5. Department of Neurological Sciences, University of Napoli Federico II-IDC Hermitage Capodimonte, Naples, Italy

    Marianna Amboni

  6. Medical Department, Novartis Farma Italia, Origgio, Italy

    Valeria Posocco & Delia Colombo

Authors
  1. Giovanni Abbruzzese
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  2. Angelo Antonini
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  3. Paolo Barone
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  4. Fabrizio Stocchi
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  5. Tiziano Tamburini
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  6. Laura Bernardi
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  7. Marianna Amboni
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  8. Laura Vacca
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  9. Valeria Posocco
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  10. Delia Colombo
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Corresponding author

Correspondence to Giovanni Abbruzzese.

Additional information

On behalf of the DEEP study group. The members of DEEP study group are listed in Appendix 1.

Appendix 1: The DEEP study group

Appendix 1: The DEEP study group

Abbruzzese G.:

Centro Parkinson, Dipartimento Neuroscienze Università degli Studi di Genova (Genova)

Albanese A.:

Neurologia I Fondazione IRCCS Istituto Nazionale Neurologico C. Besta (Milano)

Antonini A.:

U.O. Malattia di Parkinson Ospedale San Camillo (Venezia)

Barone P.:

Scuola Medica Salernitana, Università degli Studi di Salerno (Salerno)

Bentivoglio AR.:

Neurologia Università Cattolica S. Cuore Policlinico Gemelli (Roma)

Bono G.:

Neurologia Ospedale di Circolo e Fondazione Macchi (Varese)

Bonuccelli U.:

U.O. Neurologia Ospedale Versilia (Camaiore)

Cannas A.:

Neurologia Policlinico Universitario di Monserrato (Monserrato)

Ceravolo R.:

U.O. Neurologia Ospedale Santa Chiara (Pisa)

Ceravolo MG.:

Clinica Neuroriabilitazione Az. Ospedali Riuniti (Ancona)

Cicarelli G.:

Neurologia A.O.R.N. San Giuseppe Moscati (Avellino)

Cincotta M.:

Neurologia Azienda Sanitaria Firenze, Piero Palagi (Firenze)

Corengia E.:

Neurologia Ospedale Valduce (Como)

D’Amelio M.:

Neurologia Az. Osp. Univ. Policlinico “P. Giaccone” (Palermo)

De Pandis MF.:

U.O. Riabilitazione Parkinson Ospedale San Raffaele Cassino (Cassino)

Eleopra R.:

SOC Neurologia Az. Osp. Univ. S.Maria della Misericordia (Udine)

Lamberti P.:

Neurologia “Amaducci” Az. Osp. Univ. Policlinico Consorziale (Bari)

Lopiano L.:

Neurologia 4 A.S.O. Molinette (Torino)

Manzo V.:

Neurologia, Padiglione F, Amb UVA AORN A. Cardarelli (Napoli)

Marconi R.:

Neurologia Ospedale della Misericordia (Grosseto)

Mauro A.:

Struttura Dipartimentale Neuropsicologia AORN San Giovanni di Dio e Ruggi di Aragona (Salerno)

Michelucci R.:

U.O.C. Neurologia Ospedale Bellaria (Bologna)

Morgante F.:

Clinica Neurologica Policlinico G. Martino (Messina)

Onofrj M.:

CeSI, Centro Studi Invecchiamento Fondazione Università Gabriele D’Annunzio (Chieti)

Pezzoli G.:

Centro Parkinson Istituti Clinici di Perfezionamento (Milano)

Pisani V.:

Clinica Neurologica Policlinico Tor Vergata (Roma)

Pisano F.:

Neurologia Riabilitativa Fondazione Salvatore Maugeri IRCCS Veruno (Veruno)

Pramstaller PP.:

Neurologia Ospedale di Bolzano (Bolzano)

Priori A.:

Neurologia Fondazione Ospedale Maggiore Policlinico (Milano)

Quatrale R.:

UO Neurologia Arcispedale Sant’Anna (Ferrara)

Quattrone A.:

Clinica Neurologica Università Magna Grecia (Catanzaro)

Ruggieri S.:

Neurologia Istituto Mediterraneo Neuromed (Pozzilli)

Scarzella L.:

Neurologia Ospedale Evangelico Valdese (Torino)

Stocchi F.:

Dipartimento di Neurologia IRCCS San Raffaele Pisana di Roma (Roma)

Tinazzi M.:

U.O. Neurologia Ospedale Civile Maggiore, Borgo Trento (Verona)

Valzania F.:

Clinica Neurologica Nuovo Ospedale Sant’Agostino-Estense (Modena)

Zappia M.:

Clinica Neurologica I Policlinico Universitario (Catania)

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Abbruzzese, G., Antonini, A., Barone, P. et al. Linguistic, psychometric validation and diagnostic ability assessment of an Italian version of a 19-item wearing-off questionnaire for wearing-off detection in Parkinson’s disease. Neurol Sci 33, 1319–1327 (2012). https://doi.org/10.1007/s10072-012-0943-y

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  • DOI: https://doi.org/10.1007/s10072-012-0943-y

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