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Quality of life in Parkinson’s disease: Italian validation of the Parkinson’s Disease Questionnaire (PDQ-39-IT)

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Abstract

Translation and cross-cultural adaptation of the 39-item Parkinson’s Disease Questionnaire (PDQ-39) to the Italian culture was performed by Oxford University Innovation in 2008, but this version has never been validated. Therefore, we performed the process of validation of the Italian version of the PDQ-39 (PDQ-39-IT) following the “Consensus-Based Standards for the Selection of Health Status Measurement Instruments” checklist. The translated PDQ-39-IT was tested with 104 patients diagnosed with Parkinson’s disease (PD) who were recruited between June and October 2017. The mean age of the participants was 65.7 ± 10.2 years, and the mean duration of symptoms was 7.4 ± 5.3 years. The internal consistency of the PDQ-39-IT was assessed by Cronbach’s alpha and ranged from 0.69 to 0.92. In an assessment of test-retest reliability in 35 of the 104 patients, the infraclass correlation coefficient (ICC) ranged from 0.85 to 0.96 for the various subitems of the PDQ-39-IT (all p < 0.01). Spearman’s rank correlation coefficient for the validity of the PDQ-39-IT and the Italian version of the 36-Item Short Form (SF-36) was − 0.50 (p < 0.01). The results show that the PDQ-39-IT is a reliable and valid tool to assess the impact of PD on functioning and well-being. Thus, the PDQ-39-IT can be used in clinical and research practice to assess this construct and to evaluate the overall effect of different treatments in Italian PD patients.

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References

  1. de Lau LM, Breteler MM (2006) Epidemiology of Parkinson’s disease. Lancet Neurol 5:525–535. https://doi.org/10.1016/S1474-4422(06)70471-9

    Article  PubMed  Google Scholar 

  2. Valent F, Devigili G, Rinaldo S, Del Zotto S, Tullio A, Eleopra R (2018) The epidemiology of Parkinson’s disease in the Italian region Friuli Venezia Giulia: a population-based study with administrative data. Neurol Sci 39(4):699–704

    Article  Google Scholar 

  3. Baldacci F, Policardo L, Rossi S, Ulivelli M, Ramat S, Grassi E, Palumbo P, Giovannelli F, Cincotta M, Ceravolo R, Sorbi S, Francesconi P, Bonuccelli U (2015) Reliability of administrative data for the identification of Parkinson’s disease cohorts. Neurol Sci 36(5):783–786

    Article  Google Scholar 

  4. Pringsheim T, Jette N, Frolkis A, Steeves TDL (2014) The prevalence of Parkinson’s disease: a systematic review and meta-analysis. Mov Disord 29:1583–1590. https://doi.org/10.1002/mds.25945

    Article  PubMed  Google Scholar 

  5. Marinus J, Ramaker C, van Hilten JJ, Stiggelbout AM (2002) Health related quality of life in Parkinson’s disease: a systematic review of disease specific instruments. J Neurol Neurosurg Psychiatry 72:241–248

    Article  CAS  Google Scholar 

  6. Yamamoto T, Uchiyama T, Higuchi Y, Asahina M, Hirano S, Yamanaka Y et al (2017) Long term follow-up on quality of life and its relationship to motor and cognitive functions in Parkinson’s disease after deep brain stimulation. J Neurol Sci 379:18–21

    Article  Google Scholar 

  7. Zhang S, Liu D, Ye D, Li H, Chen F (2017) Can music-based movement therapy improve motor dysfunction in patients with Parkinson’s disease? Systematic review and meta-analysis. Neurol Sci 38(9):1629–1636

    Article  Google Scholar 

  8. Dogan VB, Koksal A, Dirican A, Baybas S, Dirican A, Dogan GB (2015) Independent effect of fatigue on health-related quality of life in patients with idiopathic Parkinson’s disease. Neurol Sci 36(12):2221–2226

    Article  Google Scholar 

  9. Martinez-Martin P, Jeukens-Visser M, Lyons KE, Rodriguez-Blazquez C, Selai C, Siderowf A, Welsh M, Poewe W, Rascol O, Sampaio C, Stebbins GT, Goetz CG, Schrag A (2011) Health-related quality-of-life scales in Parkinson’s disease: critique and recommendations. Mov Disord 26:2371–2380. https://doi.org/10.1002/mds.23834

    Article  PubMed  Google Scholar 

  10. EuroQol Group (1990) EuroQol--a new facility for the measurement of health-related quality of life. Health Policy 16:199–208

    Article  Google Scholar 

  11. Hunt SM, McKenna SP, McEwen J et al (1981) The Nottingham Health Profile: subjective health status and medical consultations. Soc Sci Med A 15:221–229

    CAS  PubMed  Google Scholar 

  12. Ware JE, Sherbourne CD (1992) The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care 30:473–483

    Article  Google Scholar 

  13. Bergner M, Bobbitt RA, Carter WB, Gilson BS (1981) The Sickness Impact Profile: development and final revision of a health status measure. Med Care 19:787–805

    Article  CAS  Google Scholar 

  14. Jenkinson C, Fitzpatrick R, Peto V, Greenhall R, Hyman N (1997) The PDQ-8: development and validation of a short-form parkinson’s disease questionnaire. Psychol Health 12:805–814. https://doi.org/10.1080/08870449708406741

    Article  Google Scholar 

  15. de Boer AG, Wijker W, Speelman JD, de Haes JC (1996) Quality of life in patients with Parkinson’s disease: development of a questionnaire. J Neurol Neurosurg Psychiatry 61:70–74

    Article  Google Scholar 

  16. Calne S, Schulzer M, Mak E, Guyette C, Rohs G, Hatchard S, Murphy D, Hodder J, Gagnon C, Weatherby S, Beaudet L, Duff J, Pegler S (1996) Validating a quality of life rating scale for idiopathic parkinsonism: Parkinson’s Impact Scale (PIMS). Parkinsonism Relat Disord 2:55–61

    Article  CAS  Google Scholar 

  17. Marinus J, Visser M, Martínez-Martín P et al (2003) A short psychosocial questionnaire for patients with Parkinson’s disease: the SCOPA-PS. J Clin Epidemiol 56:61–67

    Article  Google Scholar 

  18. Peto V, Jenkinson C, Fitzpatrick R, Greenhall R (1995) The development and validation of a short measure of functioning and well being for individuals with Parkinson’s disease. Qual Life Res 4:241–248. https://doi.org/10.1007/BF02260863

    Article  CAS  PubMed  Google Scholar 

  19. Jenkinson C, Fitzpatrick R, Peto V et al (1997) The Parkinson’s Disease Questionnaire (PDQ-39): development and validation of a Parkinson’s disease summary index score. Age Ageing 26:353–357

    Article  CAS  Google Scholar 

  20. Martínez-Martín P, Frades Payo B, The Grupo Centro for Study of Movement Disorders (1998) Quality of life in Parkinson’s disease: validation study of the PDQ-39 Spanish version. J Neurol 245(Suppl 1):S34–S38

    Article  Google Scholar 

  21. Bushnell DM, Martin ML (1999) Quality of life and Parkinson’s disease: translation and validation of the US Parkinson’s Disease Questionnaire (PDQ-39). Qual Life Res 8:345–350

    Article  CAS  Google Scholar 

  22. Damiano AM, McGrath MM, Willian MK et al (2000) Evaluation of a measurement strategy for Parkinson’s disease: assessing patient health-related quality of life. Qual Life Res 9:87–100. https://doi.org/10.1023/A:1008928321652

    Article  CAS  PubMed  Google Scholar 

  23. Katsarou Z, Bostantjopoulou S, Peto V, Alevriadou A, Kiosseoglou G (2001) Quality of life in Parkinson’s disease: Greek translation and validation of the Parkinson’s disease questionnaire (PDQ-39). Qual Life Res 10:159–163. https://doi.org/10.1023/A:1016720400862

    Article  CAS  PubMed  Google Scholar 

  24. Tsang K-L, Chi I, Ho S-L, Lou VW, Lee TMC, Chu LW (2002) Translation and validation of the standard Chinese version of PDQ-39: a quality-of-life measure for patients with Parkinson’s disease. Mov Disord 17:1036–1040. https://doi.org/10.1002/mds.10249

    Article  PubMed  Google Scholar 

  25. Luo W, Gui X, Wang B, Zhang WY, Ouyang ZY, Guo Y, Zhang BR, Ding MP (2010) Validity and reliability testing of the Chinese (mainland) version of the 39-item Parkinson’s Disease Questionnaire (PDQ-39). J Zhejiang Univ Sci B 11:531–538. https://doi.org/10.1631/jzus.B0900380

    Article  PubMed  PubMed Central  Google Scholar 

  26. Zhang J-L, Chan P (2012) Reliability and validity of PDQ-39: a quality-of-life measure for patients with PD in China. Qual Life Res 21:1217–1221. https://doi.org/10.1007/s11136-011-0026-1

    Article  PubMed  Google Scholar 

  27. Luo N, Tan LCS, Li SC, Soh LK, Thumboo J (2005) Validity and reliability of the Chinese (Singapore) version of the Parkinson’s Disease Questionnaire (PDQ-39). Qual Life Res 14:273–279

    Article  CAS  Google Scholar 

  28. Martínez-Martín P, Serrano-Dueñas M, Vaca-Baquero V (2005) Psychometric characteristics of the Parkinson’s disease questionnaire (PDQ-39)--Ecuadorian version. Parkinsonism Relat Disord 11:297–304. https://doi.org/10.1016/j.parkreldis.2005.02.003

    Article  PubMed  Google Scholar 

  29. Auquier P, Sapin C, Ziegler M et al (2002) Validation of the French language version of the Parkinson’s Disease Questionnaire - PDQ-39. Rev Neurol (Paris) 158:41–50

    CAS  Google Scholar 

  30. Carod-Artal FJ, Martinez-Martin P, Vargas AP (2007) Independent validation of SCOPA–psychosocial and metric properties of the PDQ-39 Brazilian version. Mov Disord 22:91–98. https://doi.org/10.1002/mds.21216

    Article  PubMed  Google Scholar 

  31. Krikmann Ü, Taba P, Lai T, Asser T (2008) Validation of an Estonian version of the Parkinson’s Disease Questionnaire (PDQ-39). Health Qual Life Outcomes 6:23. https://doi.org/10.1186/1477-7525-6-23

    Article  PubMed  PubMed Central  Google Scholar 

  32. Nojomi M, Mostafavian Z, Shahidi GA, Jenkinson C (2010) Quality of life in patients with Parkinson’s disease: translation and psychometric evaluation of the Iranian version of PDQ-39. J Res Med Sci 15:63–69

    PubMed  PubMed Central  Google Scholar 

  33. Kwon D-Y, Kim JW, Ma H-I, Ahn TB, Cho J, Lee PH, Chung SJ, Kim JS, Baik JS, Koh SB (2013) Translation and validation of the Korean version of the 39-item Parkinson’s disease questionnaire. J Clin Neurol 9:26–31. https://doi.org/10.3988/jcn.2013.9.1.26

    Article  PubMed  PubMed Central  Google Scholar 

  34. Park H-J, Sohng K-Y, Kim S (2014) Validation of the Korean version of the 39-item Parkinson’s Disease Questionnaire (PDQ-39). Asian Nurs Res 8:67–74. https://doi.org/10.1016/j.anr.2014.02.004

    Article  Google Scholar 

  35. Jesus-Ribeiro J, Vieira E, Ferreira P, Januário C, Freire A (2017) Reliability and validity of 39-item Parkinson’s Disease Questionnaire and Parkinson’s Disease Quality of Life Questionnaire. Acta Medica Port 30:395–401

    Article  Google Scholar 

  36. Galeoto G, Lauta A, Palumbo A, Castiglia SF, Mollica R, Santilli V (2015) The Barthel Index: Italian translation, adaptation and validation. Int J Neurol Neurother 2:1–7

    Google Scholar 

  37. Culicchia G, Nobilia M, Asturi M, Santilli V, Paoloni M, De Santis R et al (2016) Cross-cultural adaptation and validation of the Jebsen-Taylor hand function test in an Italian population. Rehabil Res Pract 2016:1–12

    Google Scholar 

  38. Castiglia SF, Galeoto G, Lauta A, Palumbo A, Tirinelli F, Viselli F et al (2017) The culturally adapted Italian version of the Barthel Index (IcaBI): assessment of structural validity, inter-rater reliability and responsiveness to clinically relevant improvements in patients admitted to inpatient rehabilitation centers. Funct Neurol 32(4):221

    Article  Google Scholar 

  39. Marquez MA, De Santis R, Ammendola V, Antonacci M, Santilli V, Berardi A et al (2018) Cross-cultural adaptation and validation of the “Spinal Cord Injury-Falls Concern Scale” in the Italian population. Spinal Cord 56:712–718

    Article  Google Scholar 

  40. Galeoto G, Sansoni J, Scuccimarri M, Bruni V, De Santis R, Colucci M et al (2018) A psychometric properties evaluation of the Italian version of the geriatric depression scale. Depress Res Treat 2018:1–7

    Article  Google Scholar 

  41. Murgia M, Bernetti A, Delicata M, Massetti C, Achilli EM, Mangone M, Ioppolo F, di Sante L, Santilli V, Galeoto G, Agostini F, Venditto T (2018) Inter-and intra-interviewer reliability of Italian version of Pediatric Evaluation of Disability Inventory. Ann Ig 30:153–161

    CAS  PubMed  Google Scholar 

  42. Berardi A, De Santis R, Tofani M, Marquez MA, Santilli V, Rushton PW et al (2017) The Wheelchair Use Confidence Scale: Italian translation, adaptation, and validation of the short form. Disability and rehabilitation. Assist Technol 2017:1–6

    Google Scholar 

  43. Tofani M, Candeloro C, Sabbadini M, Lucibello L, Figura M, Fabbrini G et al (2018) The psychosocial impact of assistive device scale: Italian validation in a cohort of nonambulant people with neuromotor disorders. Assist Technol 2018

  44. Galeoto G, Berardi A, De Santis R, Di Valentini L, Beccasio R, Marquez MA et al (2018) Validation and cross-cultural adaptation of the Van Lieshout test in an Italian population with cervical spinal cord injury: a psychometric study. Spinal Cord Ser Case 4(1):49

    Article  Google Scholar 

  45. Wild D, Grove A, Martin M, Eremenco S, McElroy S, Verjee-Lorenz A, Erikson P, ISPOR Task Force for Translation and Cultural Adaptation (2005) Principles of good practice for the translation and cultural adaptation process for patient-reported outcomes (PRO) measures: report of the ISPOR task force for translation and cultural adaptation. Value Health 8:94–104. https://doi.org/10.1111/j.1524-4733.2005.04054.x

    Article  PubMed  Google Scholar 

  46. Folstein MF, Folstein SE, McHugh PR (1975) Mini-mental state. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189–198

    Article  CAS  Google Scholar 

  47. Turrina C, Dewey ME, Siani R, Saviotti F, Marchione N, Siciliani O (1993) Performance of the Italian version of the mini-mental state examination in day hospital geriatric medical patients. Int J Geriatr Psychiatry 8:649–654. https://doi.org/10.1002/gps.930080805

    Article  Google Scholar 

  48. Galeoto G, Mollica R, Astorino O, Cecchi R (2015) Informed consent in physiotherapy: proposal of a form. G Ital Med Lav Ergon 37:245–254

    PubMed  Google Scholar 

  49. Hoehn MM, Yahr MD (1967) Parkinsonism: onset, progression and mortality. Neurology 17:427–442

    Article  CAS  Google Scholar 

  50. Apolone G, Mosconi P (1998) The Italian SF-36 Health Survey: translation, validation and norming. J Clin Epidemiol 51:1025–1036

    Article  CAS  Google Scholar 

  51. Mokkink LB, Terwee CB, Patrick DL, Alonso J, Stratford PW, Knol DL, Bouter LM, de Vet HCW (2010) The COSMIN checklist for assessing the methodological quality of studies on measurement properties of health status measurement instruments: an international Delphi study. Qual Life Res 19:539–549. https://doi.org/10.1007/s11136-010-9606-8

    Article  PubMed  PubMed Central  Google Scholar 

  52. Schrag A, Jahanshahi M, Quinn N (2000) How does Parkinson’s disease affect quality of life? A comparison with quality of life in the general population. Mov Disord 15:1112–1118

    Article  CAS  Google Scholar 

  53. Bartolomei L, Pastore A, Meligrana L, Sanson E, Bonetto N, Minicuci GM, Marsala SZ, Mesiano T, Bragagnolo L, Antonini A (2018) Relevance of sleep quality on caregiver burden in Parkinson’s disease. Neurol Sci 39(5):835–839

    Article  Google Scholar 

  54. Xie CL, Wang XD, Chen J, Lin HZ, Chen YH, Pan JL, Wang WW (2015) A systematic review and meta-analysis of cognitive behavioral and psychodynamic therapy for depression in Parkinson’s disease patients. Neurol Sci 36(6):833–843

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Public Health, Sapienza University of Rome, Rome, Italy

    Giovanni Galeoto

  2. “Sapienza” University of Rome, Rome, Italy

    Francesca Colalelli, Perla Massai & Anna Berardi

  3. Department of Neurosciences and Neurorehabilitation, Bambino Gesù Children’s Hospital, Rome, Italy

    Marco Tofani

  4. Department of Systems Medicine, “Tor Vergata” University of Rome, Rome, Italy

    Mariangela Pierantozzi

  5. Department of Health Professions, “Tor Vergata” University of Rome, Rome, Italy

    Annamaria Servadio

  6. Department of Human Neurosciences, Sapienza University of Rome, Viale dell’Università 30, 00185, Rome, Italy

    Andrea Fabbrini & Giovanni Fabbrini

  7. IRCCS Neuromed, Pozzilli, IS, Italy

    Giovanni Fabbrini

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  1. Giovanni Galeoto
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  2. Francesca Colalelli
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  3. Perla Massai
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Correspondence to Giovanni Fabbrini.

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All the participants included provided consent prior to the commencement of the study [48].

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Galeoto, G., Colalelli, F., Massai, P. et al. Quality of life in Parkinson’s disease: Italian validation of the Parkinson’s Disease Questionnaire (PDQ-39-IT). Neurol Sci 39, 1903–1909 (2018). https://doi.org/10.1007/s10072-018-3524-x

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