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Perioperative use of an anti-inflammatory drug on tooth sensitivity caused by in-office bleaching: a randomized, triple-blind clinical trial

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Abstract

Objectives

The aim of this study was to determine the effect of etoricoxib 60 mg on tooth sensitivity (TS) caused by in-office bleaching.

Materials and methods

A triple-blind, parallel design, randomized clinical trial was conducted on 30 healthy, young adults who received either a placebo or etoricoxib. The drugs were administered 1 h before the bleaching process and after 24 h. Treatment was performed with 35 % hydrogen peroxide gel. The TS was recorded on three scales: VAS, 0–4, and 0–100. Shade evaluations were performed before and 30 days after bleaching with a visual shade guide and a spectrophotometer. The percentage of patients who reported TS at least once during treatment and the TS intensity were evaluated by Fisher’s exact and Mann–Whitney U tests, respectively. Tooth color changes were evaluated by repeated measures ANOVA.

Results

There were no significant differences in the percentage of patients with TS, intensity of TS, and color between the groups.

Conclusions and clinical significance

The anti-inflammatory medication etoricoxib 60 mg was unable to reduce the presence and intensity of TS. NCT01300780 (protocol No. 17838/2010).

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Acknowledgments

This study was performed by Eloisa Andrade de Paula as partial fulfillment of his Ph.D.’s degree at the State University of Ponta Grossa (UEPG), Ponta Grossa, PR, Brazil. The authors would like to thanks FGM Dental Products for the generous donation of the bleaching products employed in this study. This study was partially supported by the National Council for Scientific and Technological Development (CNPq) under grants 301937/2009-5 and 301891/2010-9 as well as Araucária Foundation.

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Restorative Dentistry, School of Dentistry, State University of Ponta Grossa, Av. General Carlos Cavalcanti, 4748, Bloco M, Sala 64, Ponta Grossa, Paraná, 84030-900, Brazil

    Eloisa Andrade de Paula, Alessandro D. Loguercio, Stella Kossatz & Alessandra Reis

  2. School of Pharmacology, State University of Ponta Grossa, Av. General Carlos Cavalcanti, Ponta Grossa, Paraná, 84030-900, Brazil

    Daniel Fernandes

Authors
  1. Eloisa Andrade de Paula
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  2. Alessandro D. Loguercio
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  3. Daniel Fernandes
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  4. Stella Kossatz
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  5. Alessandra Reis
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Corresponding author

Correspondence to Alessandra Reis.

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de Paula, E.A., Loguercio, A.D., Fernandes, D. et al. Perioperative use of an anti-inflammatory drug on tooth sensitivity caused by in-office bleaching: a randomized, triple-blind clinical trial. Clin Oral Invest 17, 2091–2097 (2013). https://doi.org/10.1007/s00784-013-0918-2

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  • DOI: https://doi.org/10.1007/s00784-013-0918-2

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