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Bleaching efficacy of in-office dental bleaching with different application protocols: a single-blind randomized controlled trial

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Abstract

Objective

This randomized controlled trial aimed to evaluate the equivalence in the color change, adverse effects, self-perception (AS) and the impact on oral condition (IO) of participants submitted to different application protocols of in-office dental bleaching.

Materials and methods

165 participants were bleached with a 35% hydrogen peroxide gel (Total Blanc Office One-Step, DFL), according to the following protocols: (1) 2 applications of 20-min each (2 × 20 min); (2) 1 × 40-min and; (3) 1 × 30-min. The color change was evaluated with the Vita Easyshade spectrophotometer, Vita Classical and Vita Bleachedguide scales. The intensity and risk of tooth sensitivity (TS) and gingival irritation (GI) were recorded using a 0–10 visual analogue scale (VAS). AS and IO was assessed before and after the bleaching procedure using the Orofacial Aesthetic Scale and Oral Health Impact Profile-14, respectively.

Results

Equivalent color change were observed (p < 0.001), with no significant difference between groups. The group 2 × 20 min presented the highest risk of TS (76%, 95% CI 63 to 85), compared to the 1 × 30 min (p < 0.04). The intensity of TS and GI and the risk of GI was similar between groups (p > 0.31). Irrespectively of the group (p = 0.32), significant improvements were observed for all items of AS and IO after bleaching (p < 0.02).

Conclusions

The 1 × 30 min protocol produced equivalent color change to the other bleaching protocols with reduced risk of TS and shorter application time.

Clinical relevance

A more simplified application regimen of a single application of 30 min yields effective bleaching and patient satisfaction while minimizing undesirable side effects and improving patient satisfaction.

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Data availability

No datasets were generated or analysed during the current study.

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Acknowledgements

The authors would like to thank DFL for the generous donation of the bleaching products employed in this study. The authors would like to thank Bleaching&Bond group (Brazil).

Funding

This study was partially supported by the National Council for Scientific and Technological Development (CNPq) under grants 304817/2021-0 and 308286/2019-7 and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES) – Finance Code 001.

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Authors and Affiliations

  1. Department of Restorative Dentistry, State University of Ponta Grossa, Rua Carlos Cavalcanti, Bloco M - Uvaranas, Ponta Grossa, Parana, 4748, Brazil

    Michael Willian Favoreto, Camila Mendes Camargo, Heloisa Forville, Taynara de Souza Carneiro, Romina Ñaupari-Villasante, Michel Wendlinger, Alessandra Reis & Alessandro D. Loguercio

  2. School of Dentistry, Tuiuti University, Curitiba, Paraná, Brazil

    Michael Willian Favoreto

  3. Area of Stomatology, IDIBO research group, Health Sciences Faculty, Rey Juan Carlos University, Madrid, Spain

    Taynara de Souza Carneiro

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  1. Michael Willian Favoreto
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  2. Camila Mendes Camargo
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  3. Heloisa Forville
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  4. Taynara de Souza Carneiro
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Contributions

Conceptualization [Michael Willian Favoreto, Camila Mendes Camargo, Heloisa Forville, Taynara de Souza Carneiro, Romina Ñaupari-Villasante, Michel Wendlinger, Alessandra Reis, Alessandro D. Loguercio]; Data curation [Michael Willian Favoreto, Camila Mendes Camargo, Heloisa Forville, Taynara de Souza Carneiro, Romina Ñaupari-Villasante, Michel Wendlinger]; Formal analysis [Michael Willian Favoreto, Alessandra Reis, Alessandro D. Loguercio]; Funding acquisition [Alessandra Reis, Alessandro D. Loguercio]; Investigation [Michael Willian Favoreto, Camila Mendes Camargo, Heloisa Forville, Taynara de Souza Carneiro, Romina Ñaupari-Villasante, Michel Wendlinger, Alessandra Reis, Alessandro D. Loguercio]; Methodology [Michael Willian Favoreto, Camila Mendes Camargo, Heloisa Forville, Taynara de Souza Carneiro, Romina Ñaupari-Villasante, Michel Wendlinger, Alessandra Reis, Alessandro D. Loguercio]; Project administration [Alessandra Reis, Alessandro D. Loguercio]; Resources [Alessandra Reis, Alessandro D. Loguercio]; Software [Michael Willian Favoreto, Camila Mendes Camargo, Alessandra Reis, Alessandro D. Loguercio]; Supervision [Alessandra Reis, Alessandro D. Loguercio]; Validation [Michael Willian Favoreto, Camila Mendes Camargo, Heloisa Forville, Taynara de Souza Carneiro, Romina Ñaupari-Villasante, Michel Wendlinger]; Writing –Original Draft [Michael Willian Favoreto, Camila Mendes Camargo, Heloisa Forville, Taynara de Souza Carneiro, Romina Ñaupari-Villasante, Michel Wendlinger]; Writing –Review & Editing [Alessandra Reis, Alessandro D. Loguercio].

Corresponding author

Correspondence to Alessandro D. Loguercio.

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Ethical approval

This study was approved by the Ethics Committee of the local University (5.375.918) and registered a priori (RBR-5bj464v).

Consent to participate

All persons gave their informed consent prior to their inclusion in the study. Details that might disclose the identity of the subjects under study were omitted.

Conflict of interest

Michael Willian Favoreto declares that he has no conflict of interest. Camila Mendes Camargo declares that she has no conflict of interest. Heloisa Forville declares that she has no conflict of interest. Taynara de Souza Carneiro declares that she has no conflict of interest. Romina Ñaupari-Villasante declares that she has no conflict of interest. Michel Wendlinger declares that he has no conflict of interest. Alessandra Reis declares that she has no conflict of interest. Alessandro D. Loguercio declares that he has no conflict of interest.

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Favoreto, M.W., Camargo, C.M., Forville, H. et al. Bleaching efficacy of in-office dental bleaching with different application protocols: a single-blind randomized controlled trial. Clin Oral Invest 28, 295 (2024). https://doi.org/10.1007/s00784-024-05697-0

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