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Characterization of out-of-plane cone metal microneedles and the function of transdermal delivery

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Abstract

The key issue in the research of microneedles is how to fabricate microneedles with low cost and good quality. This paper presents a process for fabrication of cone out-of-plane Ni microneedles and characterizes their properties. The fabrication process consisted of inclined rotational MASK and wafer exposure, fine pattern transfer of polydimethylsiloxane (PDMS) and electroplating. The efficiency of transdermal delivery of baicalin, as well as related mechanical properties, are evaluated using rat skin pretreated by a 10 × 10 microneedle array. The fracture strength of the microneedle is 355 MPa. The cumulative permeability rate improves approximately 100 % due to the effect of the microneedle. The method presented in this paper offers the potential for mass production and wide choice of needle material.

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Acknowledgments

This research is supported by the Cultivating Foundation for Innovation Engineering Program of the Ministry of Education of China under grant (708037), the Chinese National Natural Science Foundation (50775149 and 60976081).

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Authors and Affiliations

  1. National Key Laboratory of Nano/Micro Fabrication Technology, Key Laboratory for Thin Film and Microfabrication of the Ministry of Education, Institute of Micro/Nano Science and Technology, Shanghai Jiao Tong University, Shanghai, 200240, China

    Jun Zhu, Ying Cao, Hong Wang, Xiang Chen & Di Chen

  2. School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, China

    Qi Shen

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  1. Jun Zhu
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  2. Qi Shen
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  3. Ying Cao
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  4. Hong Wang
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  5. Xiang Chen
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  6. Di Chen
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Correspondence to Jun Zhu.

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Zhu, J., Shen, Q., Cao, Y. et al. Characterization of out-of-plane cone metal microneedles and the function of transdermal delivery. Microsyst Technol 19, 617–621 (2013). https://doi.org/10.1007/s00542-012-1672-0

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  • DOI: https://doi.org/10.1007/s00542-012-1672-0

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