Skip to main content
SpringerLink
Log in

The fabrication and property of a novel coated out-of-plane microneedle arrays

  • Technical Paper
  • Published:
Microsystem Technologies Aims and scope Submit manuscript

Abstract

The efficiency of transdermal drug delivery (TDD) is often undermined by stratum corneum of skin. In this paper, a novel design and fabricating process was developed to coat microneedles (MNs). Testing results of facture strength of the MNs demonstrated that the Ni coated microneedle can meet the mechanical requirement for practical TDD applications. Dip-coating experiment demonstrated that it was practical to load baicalin onto the surfaces of the MNs. The amount of loaded drug was increased simply by increasing times of dip-coating operation. It was also demonstrated that upon coated by HPMC or PVP, drug can be released from the MNs in a more sustainable manner. Coating solution had great impact on drug releasing rate, indicating that the required drug concentration can be achieved by proper coating solution.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7

Similar content being viewed by others

References

  • Alfred JH, Scott AK, Diane ES, Noel GH, John AM, Ronald JP (2011) Microneedle-based intradermal delivery enables rapid lymphatic uptake and distribution of protein drugs. Pharm Res 28:107–116

    Article  Google Scholar 

  • Choi SO, Kim YC, Park JH, Hutcheson J, Gill HS, Yoon YK, Prausnitz MR, Allen MG (2010) An electrically active microneedle array for electroporation. Biomed Microdevices 12:263–273

    Article  Google Scholar 

  • Choi HJ, Bondy BJ, Yoo DG, Compans RW, Kang SM, Prausnitz MR (2013) Stability of whole inactivated influenza virus vaccine during coating onto metal microneedles. J Controll Release 166:159–171

    Article  Google Scholar 

  • Donnelly RF, Majithiya R, Singh TRR, Morrow DIJ, Garland MJ, Demir YK, Migalska K, Ryan E, Gillen D, Scott CJ, Woolfson AD (2011) Design, optimizationand characterisation of polymeric microneedle arrays prepared by a novellaser-based micromoulding technique. Pharm Res 28:41–57

    Article  Google Scholar 

  • Gill HS, Prausnitz MR (2007) Coating formulations for microneedles. Pharm Res 24:1369–1380

    Article  Google Scholar 

  • Hadgraft J, Peck J, Williams DG, Pugh WJ, Allan G (1996) Mechanisms of action of skin penetration enhancers/retarders:azone and analogues. Int J Pharm 141:17–25

    Article  Google Scholar 

  • Han MH, Hyun DH, Park HH, Lee SS, Kim CH, Kim CG (2007) A noble fabrication process or out-of-plane microneedle sheets of biocompatible polymer. J Micromech Microeng 17:1184–1191

    Article  Google Scholar 

  • Henry S, McAllister DV, Allen MG, Prausnitz MR (1998) Microfabricated microneedles: a novel approach to transdermal drug delivery. J Pharm Sci 87:922–925

    Article  Google Scholar 

  • Jiang J, Moore JS, Edelhauser HF, Prausnitz MR (2009) Intrascleral drug delivery to the eye using hollow microneedles. Pharm Res 26:395–403

    Article  Google Scholar 

  • Khanna P, Luongo K, Strom JA, Bhansali S (2010) Sharpening of hollow silicon microneedles to reduce skin penetration force. J Micromech Microeng 20:045011

    Article  Google Scholar 

  • Kim M, Jung B, Park J-H (2012) Hydrogel swelling as a trigger to release biodegradable polymer microneedles in skin. Biomaterials 33:668–678

    Article  Google Scholar 

  • Lee JW, Park JH, Prausnitz MR (2008) Dissolving microneedles for transdermal drug delivery. Biomaterials 29:2113–2124

    Article  Google Scholar 

  • Lhernould MS, Delchambre A (2011) Innovative design of hollow polymeric microneedles for transdermal drug delivery. Microsyst Technol 17:1675–1682

    Article  Google Scholar 

  • Ling XY (2010) Determination of Baicalin in Niuhuang Qinshao tablets by HPLC. Heilongjiang Med 16:886–887

    Google Scholar 

  • Moon SJ, Lee SS, Lee HS, Kwon TH (2005) Fabrication of microneedle array using LIGA and hot embossing process. Microsyst Technol 11:311–318

    Article  Google Scholar 

  • Naik A, Kalia YN, Guy RH (2000) Transdermal drug delivery: overcoming the skin’s barrier function. Pharm Sci Technol Today 3:318–326

    Article  Google Scholar 

  • Park JH, Allen MG, Prausnitz MR (2006) Polymer microneedles for controlled-release drug delivery. Pharm Res 23:1008–1019

    Article  Google Scholar 

  • Park JH, Choi SO, Kamath R, Yoon YK, Allen MG, Prausnitz MR (2007) Polymer particle-based micromolding to fabricate novel microstructures. Biomed Microdevices 9:223–234

    Article  Google Scholar 

  • Prausnitz MR (2004) Microneedles or transdermal drug delivery. Adv Drug Deliv Rev 56:581–587

    Article  Google Scholar 

  • Prausnitz MR, Langer R (2008) Transdermal drug delivery. Nat Biotechnol 26:1261–1268

    Article  Google Scholar 

  • Vrdoljak A, McGrath MG, Carey JB, Draper SJ, Hill AVS, O’Mahony C, Crean Abina M, Moore AC (2012) Coated microneedle arrays for transcutaneous delivery of live virus vaccines. J Controll Release 159:34–42

    Article  Google Scholar 

  • Widera G, Johnson J, Kim L, Libiran L, Nyam K, Daddona P, Cormier M (2006) Effect of delivery parameters on immunization to ovalbumin following intracutaneous administration by a coated microneedle array patch system. Vaccine 24:1653–1664

    Article  Google Scholar 

  • Wilke N, Mulcahy A, Ye SR, Morrissey A (2005) Process optimization and characterizationof silicon microneedles fabricated by wet etch technology. Microelectron J 36:650–656

    Article  Google Scholar 

  • Zhu Qiyun, Zarnitsyn VG, Ye L, Wen Z, Gao Y, Pan Lei, Skountzou I, Gill HS, Prausnitz MR, Yang C, Richard W (2009) Compans Immunization by vaccine-coated microneedle arrays protects against lethal influenza virus challenge. Proc Natl Acad Sci 106:7968–7973

    Article  Google Scholar 

Download references

Acknowledgments

This research was supported by the Cultivating Foundation for Innovation Engineering Program of the Ministry of Education of China under Project No. 708037, the Chinese National Natural Science Foundation under Project No. 50775149, 60976081 and 51035005.

Author information

Authors and Affiliations

  1. National Key Laboratory of Nano/Micro Fabrication Technology, Key Laboratory for Thin Film and Micro Fabrication of the Ministry of Education, Department of Microelectronics and Nanoscience, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 200240, Shanghai, People’s Republic of China

    Jun Zhu, Ying Cao, Xiang Chen & Xiaolin Zhao

  2. School of Pharmacy, Shanghai Jiao Tong University, 200240, Shanghai, China

    Qi Shen

Authors
  1. Jun Zhu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Qi Shen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ying Cao
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Xiang Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Xiaolin Zhao
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jun Zhu.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zhu, J., Shen, Q., Cao, Y. et al. The fabrication and property of a novel coated out-of-plane microneedle arrays. Microsyst Technol 22, 143–149 (2016). https://doi.org/10.1007/s00542-015-2448-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00542-015-2448-0

Keywords

Search

Navigation