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Hepatic Arterial Embolization with Doxorubicin-Loaded Superabsorbent Polymer Microspheres in a Rabbit Liver Tumor Model

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Abstract

Objectives

The pharmacokinetic profile after hepatic arterial embolization with superabsorbent microspheres (QuadraSpheres) loaded with doxorubicin was studied.

Methods

Rabbits with hepatic VX2 tumors were treated with intra-arterial administration of QuadraSpheres loaded with doxorubicin, or transarterial chemoembolization (TACE) using doxorubicin, Lipiodol and Embospheres, or hepatic arterial infusion (HAI) of doxorubicin. Tumor specimens were evaluated by fluorescence microscopy, and plasma and tumor concentrations of doxorubicin were measured.

Results

The peak plasma concentration of doxorubicin was lower in the QuadraSphere group (309.9 ng/ml) than in the HAI (673.4 ng/ml) or TACE (360.5 ng/ml) groups, suggesting higher tumor retention in the QuadraSphere group. Intratumoral doxorubicin levels declined to negligible levels at 1 and 3 days after treatment, respectively, in the HAI and TACE groups. In the QuadraSphere groups, intratumoral doxorubicin level declined after day 1, but was still detectable at 14 days after treatment and was higher than that in the other groups at 1, 3, and 7 days. Intratumoral doxorubicin fluorescence was detected at all time points in the QuadraSphere group, but only at 1 day after treatment in the TACE group.

Conclusions

Hepatic arterial administration of doxorubicin-loaded QuadraSpheres enables the sustained release of doxorubicin to hepatic tumors.

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Acknowledgments

This work was supported in part by grants from Biosphere Medical, Inc, and the John S. Dunn Research Foundation.

Conflict of interest

The authors have no other conflicts of interest.

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Authors and Affiliations

  1. Department of Diagnostic Radiology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA

    Sanjay Gupta, Kenneth C. Wright, Katherine A. Dixon & Vikas Kundra

  2. Department of Biostatistics, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 77030, USA

    Joe Ensor

  3. Department of Veterinary Medicine and Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 77030, USA

    Carolyn S. Van Pelt

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  1. Sanjay Gupta
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  2. Kenneth C. Wright
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Correspondence to Sanjay Gupta.

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Gupta, S., Wright, K.C., Ensor, J. et al. Hepatic Arterial Embolization with Doxorubicin-Loaded Superabsorbent Polymer Microspheres in a Rabbit Liver Tumor Model. Cardiovasc Intervent Radiol 34, 1021–1030 (2011). https://doi.org/10.1007/s00270-011-0154-6

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  • DOI: https://doi.org/10.1007/s00270-011-0154-6

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