Skip to main content
SpringerLink
Log in

Multiple Primary Carcinomas with Esophageal Squamous Cell Cancer: Clinicopathologic Outcome

  • Original Scientific Reports
  • Published:
World Journal of Surgery Aims and scope Submit manuscript

Abstract

The incidence of multiple primary carcinomas (MPCs) associated with esophageal cancer has increased. The purpose of this study was to analyze clinicopathologic findings for MPC and for only esophageal cancer (OEC). Of 157 patients with MPCs, 60 had synchronous cancer and 97 metachronous cancer. Another 42 patients had antecedent esophageal cancer (AEC), and 55 patients had subsequent esophageal cancer (SEC). We retrospectively analyzed the clincopathologic findings for patients in these categories. The incidence of early-stage carcinoma was higher in patients with MPCs than in those with an OEC. Of patients with MPCs, those with metachronous cancer had a higher rate of early-stage carcinoma than those with synchronous cancer. The 5-year survival rates were not significantly different for MPC and OEC patients. Patients with metachronous cancer had a significantly better prognosis than those with synchronous cancer (p = 0.017); and in the metachronous cancer group the prognosis was significantly better for patients with AEC than for those with SEC (p = 0.0005). Meticulous follow-up after treatment of a first cancer should be required to detect other early-stage carcinomas.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1
Figure 2
Figure 3

Similar content being viewed by others

References

  1. M Endo K Yoshino K Takeshita et al. (1991) ArticleTitleAnalysis of 1,123 cases of early esophageal carcinoma in Japan Dis. Esophagus 4 71–76

    Google Scholar 

  2. K Sugimachi K Kitamura K Baba et al. (1992) ArticleTitleEndoscopic diagnosis of early carcinoma of the esophagus using Lugol’s solution Gastrointest. Endosc. 38 657–661

    Google Scholar 

  3. S Natsugoe M Baba H Yoshinaka et al. (1998) ArticleTitleMucosal squamous cell carcinoma of the esophagus: a clinicopathologic study of 30 cases Oncology 55 235–241

    Google Scholar 

  4. M Baba T Aikou H Yoshinaka et al. (1994) ArticleTitleLong-term results of subtotal esophagectomy with three-field lymphadenectomy for carcinoma of the thoracic esophagus Ann. Surg. 219 310–316

    Google Scholar 

  5. H Akiyama M Tsurumara H Udagawa et al. (1994) ArticleTitleRadical lymph node dissection for cancer of the thoracic esophagus Ann. Surg. 220 364–372

    Google Scholar 

  6. H Fujita T Kakegawa H Yamana et al. (1995) ArticleTitleMortality and morbidity rates, postoperative course, quality of life, and prognosis after extended radical lymphadenectomy for esophageal cancer: comparison of three-field lymphadenectomy with two-field lymphadenectomy Ann. Surg. 222 654–662

    Google Scholar 

  7. DP Slaughter HW Southwick W Smejkal (1953) ArticleTitleField cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin Cancer . 963–968

    Google Scholar 

  8. M Yasuda H Kuwano M Watanabe et al. (2000) ArticleTitlep53 expression in squamous dysplasia associated with carcinoma of the oesophagus: evidence for field carcinogenesis Br. J. Cancer 83 1033–1038

    Google Scholar 

  9. Y Kumagai T Kawano Y Nakajima et al. (2001) ArticleTitleMultiple primary cancers associated with esophageal carcinoma Surg. Today 31 872–876

    Google Scholar 

  10. S Warren O Gates (1932) ArticleTitlemultiple primary malignant tumors: a survey of the literature and a statistical study Am. J. Cancer 16 1358–1414

    Google Scholar 

  11. InstitutionalAuthorNameInternational Union Against Cancer. (1997) TNM Classification of Malignant Tumors EditionNumber 5 Wiley-Liss New York

    Google Scholar 

  12. N Koide K Yazawa S Koike et al. (1997) ArticleTitleOesophageal cancer associated with other primary cancers: a study of 31 patients J. Gastroenterol. Hepatol. 12 690–694

    Google Scholar 

  13. RT Poon SY Law KM Chu et al. (1998) ArticleTitleMultiple primary cancers in esophageal squamous cell carcinoma: incidence and implications Ann. Thorac. Surg. 65 1529–1534

    Google Scholar 

  14. S Nagasawa M Onda K Sasajima et al. (2000) ArticleTitleMultiple primary malignant neoplasms in patients with esophageal cancer Dis. Esophagus 13 226–230

    Google Scholar 

  15. H Kuwano M Morita S Tsutsui et al. (1991) ArticleTitleComparison of characteristics of esophageal squamous cell carcinoma associated with head and neck cancer and those with gastric cancer J. Surg. Oncol. 46 107–109

    Google Scholar 

  16. P Wind MH Roullet D Quinaux et al. (1999) ArticleTitleLong-term results after esophagectomy for squamous cell carcinoma of the esophagus associated with head and neck cancer Am. J. Surg. 178 251–255

    Google Scholar 

  17. U Atabek MA Mohit-Tabatabai BF Rush et al. (1990) ArticleTitleImpact of esophageal screening in patients with head and neck cancer Am. Surg. 56 289–292

    Google Scholar 

  18. MC Yu DH Garabrant JM Peters et al. (1988) ArticleTitleTobacco, alcohol, diet, occupation, and carcinoma of the esophagus Cancer Res. 48 3843–3848

    Google Scholar 

  19. E Stefani ParticleDe N Munoz J Esteve et al. (1990) ArticleTitleMale drinking, alcohol, tobacco, diet, and esophageal cancer in Uruguay Cancer Res. 50 426–431

    Google Scholar 

  20. S Natsugoe Y Uchino F Kijima et al. (1997) ArticleTitleSynchronous and metachronous carcinomas of the esophagus and head and neck Dis. Esophagus 10 134–138

    Google Scholar 

  21. C La Vecchia ED Negri (1989) ArticleTitleThe role of alcohol in oesophageal cancer in non-smokers, and of tobacco in non-drinkers Int. J. Cancer 43 784–785

    Google Scholar 

  22. KK Cheng SW Duffy NE Day et al. (1995) ArticleTitleOesophageal cancer in never-smokers and never drinkers Int. J. Cancer 60 820–822

    Google Scholar 

  23. H Kato M Yoshikawa T Miyazaki et al. (2001) ArticleTitleExpression of p53 protein related to smoking and alcoholic beverage drinking habits in patients with esophageal cancers Cancer Lett. 167 65–72

    Google Scholar 

  24. M Mori K Mimori T Shiraishi et al. (2000) ArticleTitleAltered expression of Fhit in carcinoma and precarcinomatous lesions of the esophagus Cancer Res. 60 1177–1182

    Google Scholar 

  25. A Yokoyama T Muramatsu T Omori et al. (2002) ArticleTitleAlcohol and aldehyde dehydrogenase gene polymorphisms and oropharyngolaryngeal esophageal and stomach cancers in Japanese alcoholics Carcinogenesis 22 433–439

    Google Scholar 

  26. M Morita H Kuwano T Nakashima et al. (1998) ArticleTitleFamily aggregation of carcinoma of the hypopharynx and cervical esophagus: special reference to multiplicity of cancer in upper aerodigestive tract Int. Cancer 18 468–471

    Google Scholar 

  27. P Bidoli E Bajetta SC Stani et al. (2002) ArticleTitleTen-year survival with chemotherapy and radiotherapy in patients with squamous cell carcinoma of the esophagus Cancer 94 352–361

    Google Scholar 

  28. S Natsugoe M Ikeda M Baba et al. (2003) ArticleTitleLong-term survivors of advanced esophageal cancer without surgical treatment: a multicenter questionnaire survey in Kyushu, Japan Dis. Esophagus 16 239–242

    Google Scholar 

  29. D Riccardi K Alien (1999) ArticleTitleNutritional management of patients with esophageal and esophagogastric junction cancer Cancer Control 6 64–72

    Google Scholar 

  30. C Roberge M Tran C Massoud et al. (2000) ArticleTitleQuality of life and home enteral tube feeding: a French prospective study in patients with head and neck or oesophageal cancer Br. J. Cancer 82 263–269

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Surgical Oncology and Digestive Surgery, Kagoshima University School of Medicine, 8-35-1 Sakuragaoka, 890-8520, Kagoshima, Japan

    Shoji Natsugoe M.D., Masataka Matsumoto M.D., Hiroshi Okumura M.D., Sumiya Ishigami M.D., Yoshikazu Uenosono M.D., Tetsuhiro Owaki M.D., Sonshin Takao M.D. & Takashi Aikou M.D.

Authors
  1. Shoji Natsugoe M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Masataka Matsumoto M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hiroshi Okumura M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Sumiya Ishigami M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yoshikazu Uenosono M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Tetsuhiro Owaki M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Sonshin Takao M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Takashi Aikou M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Shoji Natsugoe M.D..

Rights and permissions

Reprints and permissions

About this article

Cite this article

Natsugoe, S., Matsumoto, M., Okumura, H. et al. Multiple Primary Carcinomas with Esophageal Squamous Cell Cancer: Clinicopathologic Outcome. World J. Surg. 29, 46–49 (2005). https://doi.org/10.1007/s00268-004-7525-y

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00268-004-7525-y

Keywords

Search

Navigation