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Acoustic radiation force impulse (ARFI) elastography for the noninvasive diagnosis of liver fibrosis in children

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Abstract

Background

Acoustic radiation force impulse (ARFI) imaging) is correlated with histopathological findings using METAVIR and semiquantitative scoring system (SSS) criteria for liver fibrosis.

Objective

To compare acoustic radiation force impulse imaging with biopsy results in the evaluation of liver fibrosis in children.

Materials and methods

Children with chronic liver disease and healthy children underwent acoustic radiation force impulse imaging liver measurements. ARFI gives a shear-wave velocity corresponding to tissue elasticity. In 39 children with liver disease, the values obtained were correlated with biopsy results. Receiver-operating characteristic (ROC) curves were used to determine the reliability of ARFI in estimating liver fibrosis in children.

Results

ARFI mean value was 1.12 in the healthy group and 1.99 in children with chronic liver disease. ROC curves show that an ARFI cutoff of 1.34 m/s is predictive of both METAVIR and SSS scores with a sensitivity of SSS > 2:0.85; METAVIR > F0:0.82. A cutoff of 2 m/s yielded a sensitivity of 100% to detect SSS > 4 or METAVIR > F2.

Conclusion

Acoustic radiation force impulse imaging is a reliable, noninvasive and rapid method to estimate moderate to severe liver fibrosis in children. It might prove useful to clinicians for fibrosis monitoring in children with liver disease and postpone the time of liver biopsy.

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Authors and Affiliations

  1. Department of Pediatric Radiology, University Hospitals Geneva, Geneva, Switzerland

    Sylviane Hanquinet & Mehrak Anooshiravani

  2. Division of Clinical Pathology, University Hospitals Geneva, Geneva, Switzerland

    Anne‐Laure Rougemont & Laura Rubbia-Brandt

  3. Division of Clinical Epidemiology, University of Geneva, Geneva, Switzerland

    Delphine Courvoisier

  4. Department of Psychology, Harvard University, Cambridge, MA, USA

    Delphine Courvoisier

  5. Department of Pediatric Gastroenterology, University Hospitals Geneva, Geneva, Switzerland

    Valérie Mclin & Michela Tempia

  6. Unité de Radiopédiatrie, Hôpital Universitaire des Enfants, 6 rue Willy Donzé, 1211, Genève 14, Switzerland

    Sylviane Hanquinet

Authors
  1. Sylviane Hanquinet
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  2. Anne‐Laure Rougemont
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  3. Delphine Courvoisier
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  4. Laura Rubbia-Brandt
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  5. Valérie Mclin
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  6. Michela Tempia
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  7. Mehrak Anooshiravani
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Correspondence to Sylviane Hanquinet.

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Hanquinet, S., Rougemont, A., Courvoisier, D. et al. Acoustic radiation force impulse (ARFI) elastography for the noninvasive diagnosis of liver fibrosis in children. Pediatr Radiol 43, 545–551 (2013). https://doi.org/10.1007/s00247-012-2595-8

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  • DOI: https://doi.org/10.1007/s00247-012-2595-8

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