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Increased serum fibronectin levels in patients with hemorrhagic fever with renal syndrome

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Abstract

Background

In view of the role of fibronectin in adhesion, signal transduction pathways and the infectious disease process, changes in serum fibronectin levels may influence disease evolution and severity in patients with hemorrhagic fever with renal syndrome (HFRS).

Methods

The levels of fibronectin were measured in serum samples from 112 patients with HFRS at various phases, and 30 healthy individuals were monitored as controls.

Results

The serum levels of fibronectin in patients with HFRS at all clinical phases were higher than those in the controls, with the levels of patients at the fever, oliguric and polyuric phases of disease significantly different from controls (P < 0.01). The serum fibronectin concentration in the patients with more severe clinical disease types was higher than that in those with milder types. The serum fibronectin level in the more severe patient group was significantly higher than that in milder patient group at the oliguric phase (P < 0.05).

Conclusions

Serum fibronectin concentration in patients with HFRS was increased and associated with disease phases and severity, suggesting the value of detection of fibronectin levels for evaluating HFRS disease progression and severity.

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Acknowledgments

We thank Professor David Pintel (Department of Molecular Microbiology and Immunology, University of Missouri-Columbia, Missouri) for his critical reading and careful revising of this manuscript. This study was supported by grants from the National Natural Science Foundation of China (Grant number: 30271176) and the Shaanxi Provincial Scientific and Technological Program (Grant number: 2004 K172G8).

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Authors and Affiliations

  1. Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi’an Jiaotong University, 710061, Xi’an, Shaanxi, China

    Qunying Han, Wen Kang, Lei Zhang, Sai Lou, Qianzi Zhao & Zhengwen Liu

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  1. Qunying Han
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  2. Wen Kang
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  3. Lei Zhang
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  4. Sai Lou
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  5. Qianzi Zhao
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  6. Zhengwen Liu
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Correspondence to Zhengwen Liu.

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Responsible Editor: C. Kasserra.

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Han, Q., Kang, W., Zhang, L. et al. Increased serum fibronectin levels in patients with hemorrhagic fever with renal syndrome. Inflamm. Res. 59, 135–139 (2010). https://doi.org/10.1007/s00011-009-0080-0

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  • DOI: https://doi.org/10.1007/s00011-009-0080-0

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