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Correlation of CD38 expression with the progression of hemorrhagic fever with renal syndrome

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Abstract

To assess the relationship between the expression of CD38 and the progression of hemorrhagic fever with renal syndrome (HFRS), we determined the levels of CD38 during different phases of HFRS and evaluated the relationship between changes in CD38 expression and the progression of HFRS. The expression of CD38 in 68 patients with HFRS was analyzed by flow cytometry, and this method was also used to determine the levels of CD4+T, CD8+T, and B lymphocytes and NK cells. Furthermore, creatinine (Cr), uric acid (UA), and urea in serum at each stage of HFRS were measured using commercial kits. The basic clinical reference values for leukocytes, platelets (PLT), and red blood cells were determined by conventional methods. The colloidal gold method was used to measure HFRS antibody levels in the patients. A significant change in CD38 expression was observed from the fever phase to the recovery phase in patients with HFRS. Moreover, the expression of CD38 was proportionally correlated with the levels of Cr, UA, and urea in serum. In contrast, there was an inverse correlation between CD38 and PLT. Interestingly, an increase in CD38 expression correlated with an increase in CD8+T lymphocytes, B cells, and NK cells, but with a decrease in CD4+T lymphocytes. The expression of CD38 is associated with the progression of HFRS, suggesting that it may be a potent indicator of the stages of this disorder.

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Funding

This work was supported by National Natural Science Foundation of China (no. 81572435).

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Authors and Affiliations

  1. Central Laboratory of Virology, Shaanxi Infectious Disease Hospital, The Eighth Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061, China

    Han-Dong Zhao, Yan-Ping Li & Peng Li

  2. Department of Bioscience, Becton, Dickinson and Company, Shanghai, 200040, China

    Wei-Wei Zhao

  3. Department of Clinical Laboratory, Xi’an Forth Hospital, 21 Jiefang Road, Xi’an, 710004, China

    Hong-Li Liu

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  1. Han-Dong Zhao
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  2. Yan-Ping Li
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  3. Wei-Wei Zhao
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  4. Peng Li
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Contributions

H.-D. Zhao: data curation, writing—original draft preparation. Y.-P. Li: visualization, investigation, supervision. W.-W. Zhao: conceptualization, methodology, software. P. Li: software, validation. H.-L. Liu: writing—reviewing, funding acquisition and editing.

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Correspondence to Hong-Li Liu.

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The authors report no conflicts of interest.

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Handling Editor: Hideki Ebihara.

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Zhao, HD., Li, YP., Zhao, WW. et al. Correlation of CD38 expression with the progression of hemorrhagic fever with renal syndrome. Arch Virol 166, 2399–2406 (2021). https://doi.org/10.1007/s00705-021-05136-5

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  • DOI: https://doi.org/10.1007/s00705-021-05136-5

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