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Neonatal hyperthyroxinaemia associated with maternal amiodarone therapy: Case report

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Summary

An infant delivered at 37 weeks gestation to a woman who received amiodarone in the last trimester of pregnancy showed biochemical evidence of hyperthyroxinaemia. Free Thyroxine levels remained elevated at day 8 but had fallen to within normal limits by one month of age. We suggest amiodarone be used only with caution during pregancy.

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References

  1. Abuid, J., Klein, A. H., Foley, T. P., Larson, P. R. Total and free Triiodothyronine and Thyroxine in early pregnancy. J. Clin. Endocrinol. 1974: 39, 263–268.

    CAS  Google Scholar 

  2. Candelpergher, G., Buchberger, R. et al. Transplacental passage of Amiodarone: Electrocardiographic and pharmacological evidence in a newborn. G. Ital. Cardiol. 1982: 12, 79–82.

    PubMed  CAS  Google Scholar 

  3. Clayton, B. E., Jenkins, P., Round, J. M. Paediatric Chemical Pathology: Clinical Tests and Reference Ranges. 1980. Blackwell, Oxford.

    Google Scholar 

  4. Costigan, D. C., Holland, F. J., Daneman, D. et al. Amiodarone therapy effects on childhood thyroid function. Paediatrics. 1986: 77, 703–708.

    CAS  Google Scholar 

  5. Lloyd, E. A., Mabin, T. A. Amiodarone in the treatment of patients with refractory symptomatic ventricular and supraventricular arrhythmias. A long term follow up study. SA Mediese Tydskrif Deel. 1983: 63, 759–763.

    CAS  Google Scholar 

  6. McKenna, W. J., Harris, L., Rowland, E. et al. Amiodarone therapy during pregnancy. Am. J. Cardiol. 1983: 51, 1231–1233.

    Article  PubMed  CAS  Google Scholar 

  7. Monteiro, E., Galvao-Teles, A., Santos, M. L. et al. Antithyroid antibodies as an early marker for thyroid disease induced by Amiodarone. Br. Med. J. 1986: 292, 227–228.

    CAS  Google Scholar 

  8. Pitcher, D., Leather, H. M., Storey, G. C., Holt, D. W. Amiodarone in pregnancy (letter). Lancet. 1983, 1, 597–598.

    Article  PubMed  CAS  Google Scholar 

  9. Robson, D. J., Jeeva, M. V., Storey, G. C., Holt, D. W. Use of Amiodarone during pregnancy. Postgrad. Med. J. 1985: 61, 75–77.

    PubMed  CAS  Google Scholar 

  10. Lambert, M. J., Burger, A. G., Galeazzi, R. L., Engler, D. Are selective increases in serum thyroxine (T4) due to iodinated inhibitors of T4 monodeiodination indicative of hyperthyroidism? J. Clin. Endocr. Metab. 1982: 55, 1058–1065.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Paediatrics, Waveney Hospital, Ballymena, Northern Ireland

    R. Tubman, J. Jenkins & J. Lim

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  1. R. Tubman
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  2. J. Jenkins
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  3. J. Lim
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Tubman, R., Jenkins, J. & Lim, J. Neonatal hyperthyroxinaemia associated with maternal amiodarone therapy: Case report. I.J.M.S. 157, 243 (1988). https://doi.org/10.1007/BF02949311

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