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The Δ5 and Δ6 desaturation of fatty acids of varying chain length by rat liver: A preliminary report

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Lipids

Abstract

The Δ6 desaturase of rat liver can accommodate substrates with a wide range of chain lengths. Δ9-cis,12-cis-Dienoic acids of chain lengths 14–22 carbon atoms were all desaturated at the Δ6 position by microsomal preparations from rat liver. By contrast, the Δ5 desaturase appeared much more chain-length sensitive. The percentage Δ5 desaturation of a series of Δ8-cis- and Δ9-trans-monoenoic acids increased with increasing chain length (from C16 to C20).

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Author notes

  1. Michael R. Pollard

    Present address: Department of Biochemistry, Medical Sciences Institute, The University, DD1 4HN, Dundee, Scotland, U.K.

Authors and Affiliations

  1. Department of Chemistry, The University, KY 16 9ST, St. Andrews, Fife, Scotland

    Michael R. Pollard & Frank D. Gunstone

  2. Unilever Research, Colworth House, MK44 1LQ, Sharnbrook, Bedford, England

    Lindsay J. Morris & Anthony T. James

Authors
  1. Michael R. Pollard
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  2. Frank D. Gunstone
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  3. Lindsay J. Morris
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  4. Anthony T. James
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Pollard, M.R., Gunstone, F.D., Morris, L.J. et al. The Δ5 and Δ6 desaturation of fatty acids of varying chain length by rat liver: A preliminary report. Lipids 15, 690–693 (1980). https://doi.org/10.1007/BF02534021

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  • DOI: https://doi.org/10.1007/BF02534021

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