Abstract
The effect of a dermorphin analog on learning was studied in a Wistar rat model of the complex food-seeking task. The preparation decreased the degree of anxiety in a dose-independent manner. In a dose of 50 μg/kg it increased the number of “well”-learning rats by intensifying the learning process in rats with initially suppressed cognitive activity. In a dose of 150 μg/kg, the opioid decreased the number of “well”-learning rats due to disturbance of motivation mechanisms, which was manifested in behavioral instability.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 9, pp. 252–255, September, 1998
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Eshchenko, O.V., Nikol'skaya, K.A., Deigin, V.I. et al. Psychostimulant effect of synthetic dermorphin analog. Bull Exp Biol Med 126, 866–868 (1998). https://doi.org/10.1007/BF02447359
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DOI: https://doi.org/10.1007/BF02447359