Summary
Optically pure (+)-beta-eudesmol is a possible starting material for the synthesis of several termite defense compounds. A two step procedure for the isolation of gram quantities of (+)-beta-eudesmol from commercially availableAmyris balsamifera oil (syn. West Indian sandalwood oil), containing 8% beta-eudesmol, was developed. Step one consisted of an efficient vacuum distillation of the total oil. Step two was a medium pressure LC separation with an AgNO3 impregnated silica gel stationary phase. Several other separation procedures failed due to the presence of many closely related sesquiterpene alcohols (75% of the oil).
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References
R. Kesselmans, J.P.B.A. Wijnberg andAE. de Groot, in preparation to be submitted for publication in J. org. Chem.
T.A. van Beek, R. Kleis, M.A. Posthumus andA. van Veldhuizen, Phytochemistry (1989) in press.
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van Beek, T.A., Kleis, R., Lelyveld, G.P. et al. Preparative isolation of (+)-beta-eudesmol fromAmyris balsamifera . Chromatographia 28, 126–128 (1989). https://doi.org/10.1007/BF02319632
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DOI: https://doi.org/10.1007/BF02319632