Skip to main content
SpringerLink
Log in

Splendic and renal infarction in systemic lupus erythematosus: Association with anti-cardiolipin antibodies

  • Case Report
  • Published:
Clinical Rheumatology Aims and scope Submit manuscript

Summary

A 37-year-old female, known to have systemic lupus erythematosus (SLE) and markedly raised anti-cardiolipin antibody levels in association with the lupus anticoagulant, presented with a symptomatic segmental splenic infarction. There was a past history of cerebral infarction. Abdominal computed tomography (CT) demonstrated the area of splenic infarction, and an asymptomatic right renal infarct. This patient illustrates the unusual occurrence of multiple visceral infarcts, in association with anti-cardiolipin antibodies, complicating SLE.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Mueh, J.R., Herbst, K.D., Rapaport, S.I. Thrombosis in patients with the lupus anticoagulant. Ann Intern Med 1980, 92, 156–159.

    PubMed  Google Scholar 

  2. Boey, M.L., Colaco, C.B., Gharavi, A.E., Elkon, K.B., Loizou, S., Hughes, G.R.V. Thrombosis in systemic lupus erythematosus: striking association with the presence of the lupus anticoagulant. Br Med J 1983, 287, 1021–1023.

    Google Scholar 

  3. Harris, E.N., Gharavi, A.E., Boye, M.L., Patel, B.M., Mackworth-Young, C.G., Loizou, S., Hughes, G.R.V. Anti-cardiolipin antibodies: Detection by radioimmunuoassay and association with thrombosis in systemic lupus erythematosus. Lancet 1983, ii, 1211–1214.

    Article  Google Scholar 

  4. Elias, M., Eldor, A. Thromboembolism in patients with the “lupus”-type circulating anticoagulant. Arch Intern Med 1984, 144, 510–515.

    Google Scholar 

  5. Asherson, R.A., Derksen, R.W.H.M., Harris, E.N., Bourma, B.N., Gharavi, A., Kater, L., Hughes, G.R.V. Chorea in systemic lupus erythematosus and “lupus-Like” disease: association with antiphospholipid antibodies. Semin Arthritis Rheum 1987, 16, 253–259.

    Article  PubMed  Google Scholar 

  6. Hall, S., Buettner, H., Luthra, H.S. Occlusive vascular disease in systemic lupus erythematosus. J Rheumatol 1984, 11, 846–850.

    PubMed  Google Scholar 

  7. Jindall, B.K., Martin, M.F.R., Gayner, A. Gangrene developing after surgery in a patient with unrecognised systemic lupus erythematosus and lupus anticoagulant. Ann Rheum Dis 1983, 42, 347–349.

    PubMed  Google Scholar 

  8. Asherton, R.A., Morgan, S.H., Harris, E.N., Gharavi, A.E., Krausz, T., Hughes, G.R.V. Arterial occlusion causing large bowel infarction — a reflection of clotting diathesis in SLE. Clin Rheumatol 1986, 5, 102–106.

    Article  PubMed  Google Scholar 

  9. Gladman, D.D., Urowitz, M.B. Venous syndromes and pulmonary embolism in systemic lupus erythematosus. Ann Rheum Dis 1980, 39, 340–343.

    PubMed  Google Scholar 

  10. Bernstein, M.L., Salusinsky-Sternbach, M., Bellfeur, M., Esseltine, D.W. Thrombotic and hemorrhagic complications in children with the lupus anticoagulant. Arch Dis Child 1984, 138, 1132–1135.

    Google Scholar 

  11. Asherson, R.A., Lanham, J.G., Hull, R.G., Gharavi, A.E., Hughes, G.R.V. Renal vein thrombosis in systemic lupus erythematosus: association with the “lupus anticoagulant”. Clin Exp Rheumatol 1984, 2, 75–79.

    PubMed  Google Scholar 

  12. Itoh, K., Hayashi, A., Kawai, T., Sumiya, M., Kano, S. Echography of splenic infarct in systemic lupus erythematosus. J Clin Ultrasound 1978, 6, 113–114.

    PubMed  Google Scholar 

  13. Austen, D.E.C., Rhymes, L.L. A Laboratory Manual of Blood Coagulation. Oxford, Blackwell Scientific Publications, 1975, 65.

    Google Scholar 

  14. Fefer, A. Diseases of the spleen and reticuloendothelial system. In: Principles of Internal Medicine, 9th ed., Editors: Isselbacher, K.J., Adams, R.A., Braunwald, E., Petersdorf, R.G., Wilson, J.D., New York, McGraw-Hill, 1980, 1581–1583.

    Google Scholar 

  15. Boston Collaborative Drug Surveillance Programme, Boston University Medical Centre. Surgically-confirmed gall bladder disease, venous thromboembolism, and breast tumors in relation to postmenopausal estrogen therapy. N Engl J Med 1974, 291, 15–21.

    Google Scholar 

  16. Astedt, B. Does estrogen replacement therapy predispose to thrombosis. Acta Gynecol Scand 1985, (Suppl 130), 71–74.

    Google Scholar 

  17. Broekmans, A.W., Engesser, L., Briet, E., Brommer, E.F.J., Bertina, R.J. Clinical manifestations of hereditary protein S deficiency. Thromb Haemostas 1985, 54 (Abstract) 57.

    Google Scholar 

  18. Panzer, S., Pabinger, I., Dudczac, R., Schulz, E., Wurz, E., Lechner, K. Protein S and anticardiolipin antibodies in patients with lupus anticoagulant with or without thrombosis. Thromb Haemostas 1987, 58, 392.

    Google Scholar 

  19. Laskin, C.A., Soloninka, C.A. Anticardiolipin antibodies: smoking gun or smoke screen? J Rheumatol 1988, 15, 7–9.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Rheumatology, Royal North Shore Hospital, St. Leonards, 2065, Sydney, NSW, Australia

    M. H. Arnold & L. Schrieber

Authors
  1. M. H. Arnold
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. L. Schrieber
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Arnold, M.H., Schrieber, L. Splendic and renal infarction in systemic lupus erythematosus: Association with anti-cardiolipin antibodies. Clin Rheumatol 7, 406–410 (1988). https://doi.org/10.1007/BF02239202

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02239202

Key words

Search

Navigation