Summary
The patient, a 44-year old woman with systemic lupus erythematosus, (SLE), developed infarction of the bowel and spleen after occlusion of the inferior mesenteric and splenic arteries, necessitating colectomy and splenectomy. She had had previous cerebral thromboses and a lower limb deep vein thrombosis. Histological examination of the involved vessels showed the presence of thrombus only with the total absence of any vasculitis. The patient demonstrated antibodies to phospholipid — the “lupus anticoagulant” (LA) and antibodies to cardiolipin in serum, both strongly associated with thromboses.
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Hughes, G.R.V. Thrombosis, abortion, cerebral disease and the lupus anticoagulant. Br Med J 1983, 287, 1088–1089.
Asherson, R.A., Chan, J.K.H., Harris, E.N., Gharavi, A.E., Hughes, G.R.V. Clinical and laboratory features associated with anticardiolipin antibodies in non — SLE patients. Arthritis Rheum 1985, 28, S77 (Suppl).
Harris, E.N., Asherson, R.A., Gharavi, A.E., Morgan, S.H., Derue, G., Hughes, G.R.V. Thrombocytopenia in SLE and related autoimmune disorders: association with anticardiolipin antibody. Br J Haematol 1985, 59, 2, 227–230.
Derve, G.J., Englert, H.J., Harris, E.N., et al. Fetal loss in systemic lupus: association with anticardiolipin antibodies. J. Obstets Gynaecol 1985, 5, 207–208.
Asherson, R.A., Mackworth - Young, C.G., Hull, R.G., et al. Pulmonary hypertension in SLE. Br Med J 1983, 287, 1024–1027.
Johansson, E.A., Lassus, A. The occurrence of circulating antibodies in patients with syphilitic and biologically false positive antilipoidal antibodies. Ann Clin Res, 1974, 6, 105.
Harris, E.N., Gharavi, A.E., Boey, M.L. et al. Anticardiolipin antibodies; detection by radioimmunoassay and association with thromboses in SLE. Lancet, 1981, 2, 1211–1214.
Asherson, R.A., Harris, E.N., Gharavi, A.E. et al. Aortic arch syndrome associated with anticardiolipin antibodies. Arthritis Rheum, 1985, 28, 594.
Ferrante, M.F., Myerson, G.E., Goldman, J.A. Subclavian thrombosis mimicking the aortic arch syndrome in systemic lupus erythematosus. Arthritis Rheum 1982, 25, 1501–1504.
Lessof, M.H., Glynn, L.E. The pulseless syndrome. Lancet, 1959, 1, 799–801.
Harris, E.N., Gharavi, A.E., Asherson, R.A., Hughes, G.R.V. Cerebral infarctions in systemic lupus erythematosus: association with anticardiolipin antibodies. Clin Exp Rheumatol 1984, 2, 47–51.
Alarcon Segovia, D., Osmundson, P.J. Peripheral vascular syndromes associated with systemic lupus erythematosus. Ann Intern Med 1965, 62, 907–919.
Jindal, B.K., Martin, M.F.R., Gayner, A. Gangrene developing after surgery in a patient with undiagnosed systemic lupus erythematosus and lupus anticoagulant. Ann Rheum Dis, 1983, 42, 347–349.
Asherson, R.A., Harris, E.N., Ghavari, A.E., Derksen, R.H.W.M., Kater, L., Lendrum, R., Bird, G., Hughes, G.R.V. Arterial occlusions associated with antibodies to cardiolipin. Arthritis Rheum 1985, 28, 589, (Suppl.).
Ashersson, R.A., Mackay, I.R., Harris E.S. Myocardial infarction in a young male with systemic lupus erythematosus, deep vein thrombosis and antiphospholipid antibodies. Br Heart J 1986: In press.
Gladman, D.D., Urowitz, M.B. Venous syndromes and pulmonary embolism in systemic lupus erythematosus. Ann Rheum Dis, 1980, 39, 340–343.
Asherson, R.A., Lanham, J.G., Hull, R.G., Boey, M.L., Gharavi, A.E., Hughes, G.R.V. Renal vein thrombosis in systemic lupus erythematosus: association with the lupus anticoagulant. Clin Exp Rheumatol 1984, 2, 75–79.
Zizic, T.M., Classen, J.N., Stevens, M.B. Acute abdominal complications of systemic lupus erythematosus and polyarteritis nodosa. J Med 1982, 73, 525–531.
Prouse, P.J., Thompson, E.M., Gumpel, J.M. SLE and abdominal pain. Br J Rheumatol 1983, 22, 172–175.
Hoffman, B.I., Katz, W.A. The gastrointestinal manifestations of systemic lupus erythematosus: A review of the literature. Semin Arthritis Rheum 1980, 9 (4) 237–247.
Asherson, R.A., Mackworth-Young, C.G., Harris, E.N., Gharavi, A.E., Hughes, G.R.V. Multiple venous and arterial thromboses associated with the lupus anticoagulant and antibodies to cardiolipin in the absence of SLE. Rheumatol Int. 1985, 5, 91–93.
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Asherson, R.A., Morgan, S.H., Harris, E.N. et al. Arterial occlusion causing large bowel infarction — a reflection of clotting diathesis in SLE. Clin Rheumatol 5, 102–106 (1986). https://doi.org/10.1007/BF02030977
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DOI: https://doi.org/10.1007/BF02030977