Summary
Twenty-one patients with acute leukemia in second to fifth remission were treated with bone marrow transplantation: 19 patients with transplants from HLA-matched siblings and two with transplants from identical twins. Twelve patients survived from 15 to 1,625 days after transplantation: six of 11 in the ALL group and six of 10 in the AML group. Recurrence of leukemia after marrow transplantation occurred in five patients. The cause of death in five patients was infection, in two patients combined with graft-versushost disease. Long-term disease-free survival can probably be achieved in 30%–35% of all patients with acute leukemia who receive a marrow transplant in second or subsequent remission.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Abbreviations
- AHTCG:
-
Anti-Human-T-Cell-Globulin
- ALL:
-
Acute lymphoblastic leukemia
- AML:
-
Acute myeloblastic leukemia
- BMT:
-
Bone marrow transplantation
- CMV:
-
Cytomegalyvirus
- CSA:
-
Cyclosporin A
- GVHD:
-
Graft versus host disease
- KJ:
-
Karnofsky Index
References
Thomas ED, Buckner CD, Clift RA, Fefer A, Johnson FL, Neiman PE, Sale GE, Sanders JE, Singer JW, Shulman H, Storb R, Weiden PL (1979) Marrow transplantation for acute nonlymphoblastic leukemia in first remission. N Engl J Med 301:597–599
Blume KG, Beutler E, Bross KJ, Chillar RK, Ellington OB, Fahey JL, Farbstein MJ, Forman SJ, Schmidt GM, Scott EP, Spruce WE, Turner MA, Wolf JL (1980) Bonemarrow ablation and allogeneic marrow transplantation in acute leukemia. N Engl J Med 302:1041–1046
Powles RL, Clink HM, Bandini G, Watson JG, Spence D, Jameson B, Kay HEM, Morgenstern G, Hedley D, Lumley H, Lawson D, Barrett A, Lawler S, McElwain TJ (1980) The place of bone-marrow transplantation in acute myelogenous leukemia. Lancet I:1047–1050
Creutzig U, Schellong G, Ritter J, Sutor AH, Riehm H, Langermann HJ, Jobke A, Kabisch H (1982) Improved results in treatment of acute myelogenous leukemia in children — Report of the German Cooperative AML Study BFM-78. In: Neth R, Gallo RC, Greaves MF, Moore MAS, Winkler K (eds) Modern trends in human leukemia, V. Springer, Berlin Heidelberg New York, pp 46–55
Henze G, Langermann HJ, Fengler R (1982) Therapiestudie BMFT 79/81 zur Behandlung akuter lymphoblastischer Leukämien bei Kindern und Jugendlichen. Intensivierte Reinduktionstherapie für Patientengruppen mit unterschiedlichem Rezidivrisiko. Klin Pediat 194:195–203
Link H, Frauer HM, Wilms K, Waller HD (1983) Wandel der Therapieergebnisse bei akuter Leukämie unter Anwendung verschiedener Behandlungsschemata, mit besonderer Berücksichtigung spezieller gnotobiotischer Maßnahmen. Klin Wochenschr 61:329–338
Hoelzer D, Thiel E, Löffler H, Bodenstein H, Büchner T, Messerer D (1982) For the German Multicentre ALL/AUL Study Group: Multicentre pilot study for therapy of acute lymphoblastic and acute undifferentiated leukaemia in adults. In: Neth R, Gallo RC, Greaves MF, Moore MAS, Winkler K (eds) Modern trends in human leukemia, V. Springer, Berlin Heidelberg New York, pp 36–40
Wilms K, Link H, Meyer P, Ostendorf P, Schüch K, Waller HD, Wernet P, Niethammer D, Dopfer H, Schneider W, Schunter F, Breitling G, Frommhold W, Seeger G, Voss AC (1982) Knochenmarktransplantation bei Patienten mit Leukämien. Klin Wochenschr 60:1279–1287
Rodt H, Thierfelder S, Bender-Götze C, Dopfer R, Haas FJ, Janka G, Kolb HJ, Link H, Netzel B, Niethammer D, Schüch K, Wilms K (1981) Serological inhibition of graft versus host disease: Recent results in 28 patients with leukemia. In: Neth R, Gallo RC, Greaves MF, Moore MAS, Winkler K (eds) Modern trends in human leukemia, V. Springer, Berlin Heidelberg New York, pp 92–96
Thomas ED, Storb R (1970) Technique for human marrow grafting. Blood 36:507–515
Thomas ED, Buckner CD, Banaji M, Clift RA, Fefer A, Flournoy N, Goodell BW, Hickman RO, Lerner KG, Neiman P, Sale GE, Sanders JE, Singer J, Stevens M, Storb R, Weiden P (1977) One hundred patients with acute leukemia treated by chemotherapy total body irradiation, and allogeneic marrow transplantation. Blood 49:511–533
Gale RP (1980) Clinical trials of bone marrow transplantation in leukemia. In: Gale RP, Fox CE (eds) Biology of bone marrow transplantation. Academic Press, New York, pp 11–27
Appelbaum FR, Clift RA, Buckner CD, Stewart P, Storb R, Sullivan KM, Thomas ED (1983) Allogeneic marrow transplantation for acute nonlymphoblastic leukemia after first relapse. Blood 61:949–653
Buckner CD, Clift RA, Thomas ED, Sanders JE, Hackman R, Stewart PS, Storb R, Sullivan KM (1982) Allogeneic marrow transplantation for patients with acute non-lymphoblastic leukemia in second remission. Leuk Res 6:395–399
Buckner CD, Clift RA, Thomas ED, Sanders JE, Stewart PS, Storb R, Sullivan KM, Hackman R (1982) Allogeneic marrow transplantation for acute non-lymphoblastic leukemia in relapse using fractionated total body irradiation. Leuk Res 6:389–394
Badger C, Buckner CD, Thomas ED, Clift RA, Sanders JE, Stewart PS, Storb R, Sullivan KM, Shulman H, Flournoy N (1982) Allogeneic marrow transplantation for acute leukemia in relapse. Leuk Res 6:383–387
Gale RP, Kay HEM, Rimm A, Bortin M (1982) Bone marrow transplantation for acute leukemia in first remission. Lancet II:1006–1008
Bortin MM, Gale RP, Kay HEM, Rimm AA (1983) Bone marrow transplantation for acute myelogenous leukemia. JAMA 249:1166–1175
Kubanek B, Ernst P, Schäfer U, Ostendorf P, Wolf H (1984) A controlled trial of intravenous hyperimmunglobulin in the prevention of cytomegalovirus infection in bone marrow transplant recipients. Exp Haematol [Suppl 15] 12:111–112
Ostendorf P, Ehninger G, Wernet P, Niethammer D, Dopfer R (1984) CMV-Infektionen nach Knochenmark-transplantation. In: Kornhuber B (ed) Patient Infektion Immunglobulin, V. Springer, Berlin Heidelberg New York, pp 69–81
Author information
Authors and Affiliations
Additional information
Dedicated to Prof. Dr. Dr. h.c. H.E. Bock on the occasion of his 80th birthday
Rights and permissions
About this article
Cite this article
Ostendorf, P., Ehninger, G., Kallmayer, M.L. et al. Bone marrow transplantation for acute leukemia in second or subsequent remission. Klin Wochenschr 62, 1081–1085 (1984). https://doi.org/10.1007/BF01711377
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01711377