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Congenital esophageal atresia

Lipase activity is present in the esophageal pouch and stomach

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Abstract

Lipolytic activity was studied in aspirates from the esophageal pouch and from the stomach of eight infants with congenital esophageal atresia. Lipolytic activity, tested with doubly labeled ([3H]glyceryl, [14C]fatty acid) oong-chain triglyceride was present in esophageal and gastric aspirates. The activity in esophageal aspirates was in the range of 2.7–130 nmol/min/ml aspirate and that in gastric aspirates was in the range of 2.9–40.4 nmol/min/ml aspirate. The reaction products of lipolytic activity in esophageal and gastric aspirates were a mixture of mono- and diglycerides, blycerol, and free fatty acids. The lipolytic activity at the two sites—esophagus and stomach—varied with respect to pH optimum (5.0–7.6 and 6.0–6.5, respectively) and reaction products (glycerol 41.6±20% and 7.3±4.6%, respectively). These findings confirm the earlier observations that digestion of dietary fat is initiated in the stomach and suggest that the lipolytic activity present in gastric contents originates concomitantly from the oral-esophageal area as well as from the stomach. These studies do not exclude the possibility that the lipolytic activity in the stomach of infants with esophageal atresia could originate in regurgitated intestinal contents.

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Authors and Affiliations

  1. Department of Physiology and Biophysics, Georgetown University Medical School, Washington, D.C., USA

    Carol Salzman-Mann MSc,  Margit Hamosh PhD, K. N. Sivasubramanian MD, A. Bar-Maor MD, Oren Zinder PhD, Gordon B. Avery MD, John B. Watkins MD & Paul Hamosh MD

  2. Department of Pediatrics, Georgetown University Medical School, 3900 Reservoir Road, N.W., 20007, Washington, D.C.

    Carol Salzman-Mann MSc,  Margit Hamosh PhD, K. N. Sivasubramanian MD, A. Bar-Maor MD, Oren Zinder PhD, Gordon B. Avery MD, John B. Watkins MD & Paul Hamosh MD

  3. Rambam University Hospital, Haifa, Israel

    Carol Salzman-Mann MSc,  Margit Hamosh PhD, K. N. Sivasubramanian MD, A. Bar-Maor MD, Oren Zinder PhD, Gordon B. Avery MD, John B. Watkins MD & Paul Hamosh MD

  4. Children's Hospital Medical Center, Washington, D.C.

    Carol Salzman-Mann MSc,  Margit Hamosh PhD, K. N. Sivasubramanian MD, A. Bar-Maor MD, Oren Zinder PhD, Gordon B. Avery MD, John B. Watkins MD & Paul Hamosh MD

  5. Children's Hospital Medical Center, Boston, Massachusetts

    Carol Salzman-Mann MSc,  Margit Hamosh PhD, K. N. Sivasubramanian MD, A. Bar-Maor MD, Oren Zinder PhD, Gordon B. Avery MD, John B. Watkins MD & Paul Hamosh MD

Authors
  1. Carol Salzman-Mann MSc
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  2. Margit Hamosh PhD
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  3. K. N. Sivasubramanian MD
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  4. A. Bar-Maor MD
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  5. Oren Zinder PhD
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  6. Gordon B. Avery MD
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  7. John B. Watkins MD
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  8. Paul Hamosh MD
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Additional information

This study was supported by NIH grants HD-10823 and AM026641.

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Salzman-Mann, C., Hamosh, M., Sivasubramanian, K.N. et al. Congenital esophageal atresia. Digest Dis Sci 27, 124–128 (1982). https://doi.org/10.1007/BF01311705

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  • DOI: https://doi.org/10.1007/BF01311705

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