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Duodeno-GER

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Gastroesophageal Reflux in Children

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Abstract

Gastroesophageal reflux disease is a multifactorial disorder in children and adults and results from reflux of gastric contents into the esophagus. Animal studies suggest the possibility of synergism between acid and pepsin and conjugated bile acids with a damaging potential for the esophageal mucosa. Human studies show an interaction between acid and duodenogastroesophageal reflux in inducing symptoms and lesions.

Gastroesophageal reflux symptoms are more related to acid reflux events than to nonacid reflux events. The role of duodenogastroesophageal reflux has been evaluated by endoscopy with biopsies, scintigraphy, aspiration studies, esophageal pH monitoring/impedance, and bilirubin monitoring. Therapeutic options are reducing the secretion of gastric acid, prokinetics, baclofen, mucosal protective agents, and surgery.

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Abbreviations

DGER:

Duodenogastroesophageal reflux

GERD:

Gastroesophageal reflux disease

GI:

Gastrointestinal

HIDA:

Hepatobiliary iminodiacetic acid scan

PPI:

Proton pump inhibitor

ROS:

Reactive oxygen species

Tc-99 m :

Technetium-99 m

TEER:

Transepithelial resistance

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Authors and Affiliations

  1. University Hospital Leuven, Leuven, Belgium

    Ilse Hoffman

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  1. Ilse Hoffman
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Correspondence to Ilse Hoffman .

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Editors and Affiliations

  1. Vrije Universitiet Brussel (VUB), UZ Brussel KidZ Health Castle, Brussels, Belgium

    Yvan Vandenplas

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Hoffman, I. (2022). Duodeno-GER. In: Vandenplas, Y. (eds) Gastroesophageal Reflux in Children. Springer, Cham. https://doi.org/10.1007/978-3-030-99067-1_5

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  • DOI: https://doi.org/10.1007/978-3-030-99067-1_5

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-99066-4

  • Online ISBN: 978-3-030-99067-1

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