Abstract
Synthesis of35S-labeled taurocholic acid was studied in dogs with a gall bladder fistula kept on a high-cholesterol diet (2 g/kg). In the first period (1–2 months) of feeding on a high-cholesterol diet a marked increase in the synthesis of [35S]taurocholic acid was observed. After 5–6 months, in the period of development of the pathological process in the liver, the synthesis and secretion of bile acids and the formation of a cholesterol residue in the bile were reduced. The serum cholesterol level in these dogs was increased but not significantly.
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Kryukova, L.V. Taurocholic acid synthesis in dogs on a high cholesterol diet. Bull Exp Biol Med 85, 742–745 (1978). https://doi.org/10.1007/BF00806152
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DOI: https://doi.org/10.1007/BF00806152