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Effect of thyrotrophin releasing hormone on secretion of thyrothrophic hormone and prolactin in a monolayer culture of rat adenohypophysis

  • Experimental Biology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Cells of the adenophypophysis in a primary 5–8-day monolayer culture react to addition of thyrotrophin releasing hormone (TRH) by rapid dose-dependent liberation of thyrotrophic hormone (TSH) and prolactin into the culture medium. This effect is independent of the content of serum in the nutrient medium. The thyroid hormone thyroxin blocks the stimulating action of TRH on the secretion of TSH, but not of prolactin. The blocking effect of thyroxin is evidently manifested not on cell membranes, but in the cytoplasm distally to the effect of cyclic AMP, along the pathway of transmission of the hormonal signal.

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Authors
  1. I. S. Komolov
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  2. L. G. Morozova
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  3. I. Fazekas
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  4. M. Fecete
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  5. G. Rappay
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  6. V. P. Fedotov
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Komolov, I.S., Morozova, L.G., Fazekas, I. et al. Effect of thyrotrophin releasing hormone on secretion of thyrothrophic hormone and prolactin in a monolayer culture of rat adenohypophysis. Bull Exp Biol Med 85, 218–220 (1978). https://doi.org/10.1007/BF00800132

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  • DOI: https://doi.org/10.1007/BF00800132

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