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Clofibrate-induced myopathy in the rat

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Summary

Rats were given daily injections of 0.2 or 0.5 g/kg chlorophenoxyisobutyrate (clofibrate) for 9 to 46 days. Lower leg muscles were studied with light and electron microscopy.

Daily treatment with 0.5 g/kg of the drug for 26–46 days caused myopathic changes.

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Teräväinen, H., Larsen, A. & Hillbom, M. Clofibrate-induced myopathy in the rat. Acta Neuropathol 39, 135–138 (1977). https://doi.org/10.1007/BF00703319

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  • DOI: https://doi.org/10.1007/BF00703319

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