Summary
Hematogenous metastases of carcinoma to dorsal root ganglia was found in 2 of approximately 500 consecutive autopsies in which a lumbar dorsal root ganglion was routinely examined microscopically. The primary tumors were poorly differentiated colonic adenocarcinoma and oat cell carcinoma of the lung, both with widespread hematogenous metastases which spared the central nervous system. No symptoms were detected clinically. In the same series of patients the sural nerve as well as the lumbar plexus were histologically sampled but no examples of distant endoneurial metastases were found. The vascular endothelium of dorsal root ganglia is fenestrated and, presumably as a consequence, provides no bloodganglion barrier. This microvascular difference may account for the susceptibility of the ganglia to metastases when compared to nerve trunks which possess unfenestrated endothelium and blood-nerve barrier.
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References
Asbury, A. K., Johnson, P. C.: Pathology of the peripheral nerve. Philadelphia: W. B. Saunders Co. (in press, 1977)
Barber, J. R., Coventry, M. B., McDonald, J. R.: Spread of soft tissue sarcomata of extremities along peripheral nerve trunks. J. Bone Jt. Surg.39, 534–540 (1957)
Dodd, G. D., Dolan, P. A., Ballantyne, A. J., Ibanez, M. L., Chan, P.: The dissemination of tumors of the head and neck via the cranial nerves. Radiol. Clin. N. Amer.8, 445–461 (1970)
Johnson, P. C.: Fenestrated endothelium in the human peripheral nervous system. J. Neuropath. exp. Neurol. (in press, 1977)
Olsson, Y.: Studies on vascular permeability in peripheral nerves. IV. Distribution of intravenously injected protein tracers in the peripheral nervous system of various species. Acta neuropath. (Berl.)17, 114–126 (1971)
Olsson, Y.: Vascular permeability in the peripheral nervous system. Chapter 10. In: Peripheral neuropathy (eds. P. J. Dyck, P. K. Thomas, E. H. Lambert). Philadelphia: W. B. Saunders Co. 1975
Russell, D. S., Rubinstein, L. J.: Pathology of tumors of the nervous system. London: Edward Arnold Ltd., 1971
Taylor, H. B., Norris, H. J.: Epithelial invasion of nerves in benign disease of the breast. Cancer20, 2245–2249 (1967)
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Johnson, P.C. Hematogenous metastases of carcinoma to dorsal root ganglia. Acta Neuropathol 38, 171–172 (1977). https://doi.org/10.1007/BF00688567
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DOI: https://doi.org/10.1007/BF00688567